Vasculitis

Question 1

What is vasculituis

Answer 1

Inflammation and fibrinoid necrosis of the blood vessel wall

Question 2

Importance of vasculitis

Answer 2

SITA
S Severe systemic disorders that can lead to organ failure and other fatalities
I Ischemia of tissues or organs supplied
T thromboembolism
A Aneurysms

Question 3

Aetiology of Vasculitis

Answer 3

Infections,drugs,autoantibodies,Malignancy, abnormal circulating plasma proteins, underlying systemic disease
However, 50% are said to be idiopathic

Question 4

Pathogenesis of Vasculitis

Answer 4

IMI DIVWIP
The two main pathogenic mechanisms of vasculitis are immune mediated inflammation and direct invasion of vascular wall by infectious pathogens.
Infections may also indirectly cause vasculitis by triggering crossreactivity and forming immune complexes that deposit on bv wall

Question 5

Classification of vasculitis

Answer 5

Based on infection- infectious and non infectious
Based on size

Question 6

Infectious vasculiits is further divided into

Answer 6

Endarteritis obliterans
Non syphilitic infective arteritis
Syphilitic arteritis which is further divided into cerebral syphilitic arteritis and syphilitic aortitis

Question 7

About endarteritits obliiterans

Answer 7

A non specific inflammatory response of arteries and arterioles to a variety of irritants including chemicals, radiation etc
It usually results in occlusion of the lumen of small arteries
Observed at the base of Chronic ulcer like PUD

Question 8

Non infectious vasculitis

Answer 8

Deposition of immune complexes
Direct attack on vessels by circulating antibodies
Anitineutrophil cytoplasmic antibodies
Various forms of cell mediated immunity

Question 9

Chronic infections with hepatitis B virus is associated with some cases of

Answer 9

Polyarteritis nodosa

Question 10

P-ANCA is directed mainly against

Answer 10

Myeloperoxidase

Question 11

C-ANCA is directed mainly against

Answer 11

Proteinase 3

Question 12

ANCA is typically associated with large vessel vasculitis .t/f

Answer 12

F…small vessel vasculitis like wegener’s and microscopic polyangitis

Question 13

Classification of Vasculitis based on size of blood vessel

Answer 13

Song

Question 14

Giant Cell Arteritis

Answer 14

A focal ,chronic, granulomatous inflammation often found in the temporal arteries
It is one of te most common forms of vasculitis that affects mainly the large and medium sized branches of the Carotid artery.

Question 15

Temporal arteritis is rare before what age?

Answer 15

50 years

Question 16

Clinical features of giant cell arteritis

Answer 16

V-CHOPS
V-Visual symptoms

C-Claudication of muscles of mastication
H-Headache that is sharp, localised and throbbing
O-Giant O
P-Palpable tenderness over temporal artery with thickening
S- Systemic malaise

Question 17

Prognosis of GCA

Answer 17

Tends to be benign and self limiting
Symptoms subside in 6 to 12 months
Response to corticosteroid therapy is often dramatic with symptoms subsiding within days
Anti -TNF therapy is also effective