Vasculitis Flashcards
Name one type of vasculitis that affects the small vessels
Henoch-Schonlein purpura- HSP
Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss syndrome)
Microscopic polyangiitis
Granulomatosis with polyangiitis (Wegner’s)
Name one type of medium sized vasculitis
Polyarteritis nodosa
Kawasaki Disease !!!!!!
Name one large vessel type vasculitis
GCA
Takayasu’s arteritis
List three aspects of the presentation of vasculitis
purpura
joint and muscle pain
peripheral neuropathy
renal impairment
anterior uveitis and scleritis
hypertension
GI disturbance
List two systemic features of vasculitis
fatigue
fever
weight loss
anorexia
anaemia
What is the main blood test for vsaculitis?
ANCA
What is the management of vasculitis
steroids- oral, IV, nasal, inhaled
Immunosuppressants- methotrexate, azathioprine
Which vasculitis might inhaled steroids be useful for?
churg-strauss syndrome= eosinophilic GPA
Name one vasculitis that typically affects children
Kawasaki disease
HSP
What is the typical dermatological distribution of HSP?
purpuric rash covering limbs and buttocks
What are the four classic features of HSP?
purpura
joint pain
abdo pain
renal involvement
Which renal condition is associated with HSP?
IgA nephritis
what is the management of HSP?
supportive! full recovery within 4-6 weeks (without kidney involvement)
what are the complications of HSP?
recurrence 1/3
end stage renal failure 1%
name one feature of churg-strauss syndrome= EGPA
lung and skin problems
Which vsaculitis presents with elevated eosinophil levels?
churg-strauss syndrome
Which vasculitis is associated with epistaxis?
granulomatosis with polyangiits
What are the features of granulomatosis with polyangiitis
epistaxis
hearing loss
sinusitis
saddle shaped nose- perforated nasal septum
cough wheeze
haemoptysis
glomerulonephritis
polyarteritis nodosa is associated with which infections?
Hep B
Hep C
HIV
name two features of kawasaki disease
fever
erythematous rash
bilateral conjunctivitis
erythema and desquamation of palm and soles
strawberry tongue
What is a serious complication of kawasaki disease?
coronary artery aneurysm
where does takayasu’s arteritis most commonly affect?
aorta
Does GCA just affect the temporal artery?
no, affects aorta and its major branches
What is the classic distribution of HSP?
purpuric rash over buttocks and thighs
What is a classic trigger for HSP?
strep sore throat
saddle nose deformity is a feature of which vasculitis?
GPA
