Vasculitis Flashcards
what are the types of small vessel vasculitis
HSP
EGPA
Microscopic polyangiitis
GPA
medium vessel vasculitis
polyarteritis nodosa
EGPA
Kawasaki disease
large vessel vasculitis
Giant cell arteritis
Takayadu’s arteritis
which types of vasculitis are associated with p-ANCA
Microscopic polyangitis
EGPA
which types of vasculitis are associated with C-ANCA
GPA
G is a similar shape to C
how does HSP present
purpuric rash affecting lower limbs or buttocks in children
joint pain
Abdominal pain
renal involvement (IgA nephritis)
what causes the inflammation in HSP
IgA
often triggered by an URTI
management of HSP
supportive
analgesia, rest, hydration
How does EGPA present
lung and skin problems
severe asthma
paranasal sinusitis
pulmonary infiltrates
mono neuritis multiplex or polyneuropathy
how does microscopic polyangiitis present
RENAL FAILURE
can also affect lungs but NOT the nasopharynx
how does GPA present
nose bleeds saddle shaped nose sinusitis cough wheeze haemoptysis glomerulonephritis
how does polyarteritis nodes present
medium vessel vasculitis associated with Hep B
rash called lived reticularis - mottled and purple
how is ANCA associated vasculitis treated
if no organ involvement
-methotrexate + steroids
if systemic with organ involvement
-cyclophosphamide + steroids
plasma exchange if creatinine >500
if progressive and unresponsive to steroids
- IVIG
- Rituximab
