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STEP > Vasculitides (are da worst) > Flashcards

Vasculitides (are da worst) Flashcards

1
Q

Giant cell temporal arteritis demographics

A

Elderly females

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2
Q

GCA symptoms

A

Unilateral headache, jaw claudication, can cause unilateral/irreversible blindness

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3
Q

MOA of blindness in GCA

A

Opthalmic artery occlusion (disease affects branches of carotid a. most frequently)

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4
Q

GCA association

A

Polymyalgia rheumatica

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5
Q

Histology of GCA

A

Granulomatous inflammation along the internal elastic lamina –> focal destruction and fibrosis of vessel wall –> wall thickening, luminal narrowing

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6
Q

Takayasu arteritis demographic

A

Asian females <40yrs

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7
Q

Takayasu arteritis signs

A

Weak upper extremity pulses, fever, night sweats, arthritis, myalgias, skin nodules, ocular disturbances

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8
Q

Takayasu arteritis histology

A

Mononuclear inflammation w/ giant cells through full thickness of vessel wall (aortic arch and branches), w/ fibrosis, assc. w/ wall thickening and luminal narrowing

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9
Q

Granulomatosis w/ polyangiitis test

A

C-ANCA (anti PR3)

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10
Q

Granulomatosis w/ polyangiitis other name

A

Wegeners

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11
Q

Granulomatosis w/ polyangiitis signs

A

Upper RT: perforation of nasal septum, chronic sinusitis, otitis media, mastoiditis, saddle nose
Lower RT: hemoptysis, cough, dyspnea
Kidneys: hematuria, red cell casts

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12
Q

Granulomatosis w/ polyangiitis histology

A

Necrotizing granulomas of small vessels, necrotizing glomerulonephritis, necrotizing granulomas in lung/upper airway

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13
Q

Polyarteritis nodosa demographics

A

Young/middle aged men

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14
Q

Polyarteritis nodosa association

A

Hep B pos in 30%

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15
Q

Polyarteritis nodosa signs

A

Fever, wt. loss, malaise, headache
GI: abdominal pain, melena
HTN, neuro dysfxn, cutaneous eruptions, renal damage
NO LUNGS

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16
Q

Polyarteritis nodosa histology

A

Fibrinoid necrosis and thrombosis alternating w/ regions of vascular wall fibrosis

17
Q

Kawasaki disease demographics

A

Asian child <4yrs

18
Q

Kawasaki other name

A

Mucocutaneous lymph node syndrome

19
Q

Kawasaki signs

A

Conjunctival injxn, rash (polymorphous–>desquamating), Adenopathy (cervical), Strawberry tongue, Hand/foot changes (edema, erythema), fever

CRASH and burn

20
Q

Kawasaki complications

A

Coronary artery aneurysms, thrombosis, rupture –> death

21
Q

Tx of Kawasaki

A

IVIG and aspirin

22
Q

Microscopic polyangiitis signs

A 
Involvement of kdiensy, lung, skin -- pauci-immune glomerulonephritis and palpable purpura
NO NASOPHARYNGEAL (like in GwP)
23
Q

Microscopic polyangiitis histology

A

Similar to polyarteritis nodosa w. fibrinoid necrosis except w/ smaller vessels, fragmented neuts (leukocytoclasia), and similar age of lesions

24
Q

Henoch schonlein purpura demographic

A

Most common systemic vasculitis in kiddos

25
Q

Henoch schonlein purpura association

A

Follow URI, IgA nephropathy (Berger disease)

26
Q

Triad of Henoch Schonlein Purpura

A

Skin – palpable purpura
Arthralgias
GI: abdominal pain

27
Q

Henoch Schonlein purpura histology

A

Necrotizing vasculitis w/ depositions of IgA immune complexes and C3 (also in glomerular mesangium)

28
Q

Thromboangiitis obliterans other name

A

Buerger disease

29
Q

Thromboangiitis obliterans demographic

A

heavy smoking men under 40

30
Q

Thromboangiitis obliterans signs

A

Intermittent claudication–>gangrene/autoamputation of digits

31
Q

Thromboangiitis obliterans histology

A

Segmental thrombosing vasculitis, fibrosis, extension into veins/nerves –> painful

32
Q

Eosinophilic granulomatosis w/ polyangiitis other name

A

Churg Strauss

33
Q

Eosinophilic granulomatosis w/ polyangiitis histology

A

Lots and lots of eo’s w/ granulomas

34
Q

Eosinophilic granulomatosis w/ polyangiitis signs

A

Asthma, sinusitis, skin nodules, purpura, peripheral neuropathy (foot/wrist drop), heart, GI, kidneys (pauci-immune glomerulonephritis)

35
Q

Eosinophilic granulomatosis w/ polyangiitis demographic

A

Middle aged w/ long history of asthma

36
Q

Eosinophilic granulomatosis w/ polyangiitis association

A

p-ANCA (anti-MPO), increaed IgE

37
Q

Hereditary hemorrhagic telangietasia findings

A

Blanching skin lesions, recurrent epistaxis, skin discolorations, AVMs, GI bleeding, hematuria

38
Q

Hereditary hemorrhagic telangiectasia other name

A

Osler Weber Rendu

STEP (15 decks)

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