Vasculitides

Question 1

Types of small cell vasculitis

Answer 1

GPA

eGPA

MPA

Question 2

Types of medium cell vasculitis

Answer 2

Kawasaki

Polyarteritis nodosa

Question 3

Types of large cell vasculitis

Answer 3

Takayasu arteritis

Giant Cell Arteritis

Question 4

GCA typically affects (younger/older) patients

Takayasu arteritis typically affects (younger/older) patients

Answer 4

GCA - older (>50 yrs)

TA - younger (<50), also 100-times more likely in SE Asian people and most commonly affecting women

Question 5

Early features of large cell vasculitis?

Answer 5

Low-grade fever

Malaise

Night sweats

Weight loss

Fatigue

Arthralgia

Claudication in upper/lower limbs

Question 6

Antibodies associated with GPA

Answer 6

c-ANCA and PR3

Question 7

What is the most important complication associated with MPA to be aware of?

Answer 7

Glomerulonephritis

Question 8

What is the classic ANCA-negative vasculitis?

What group does it most commonly affect and what are the symptoms?

Answer 8

Henoch-Schonlein Purpura

Commonly affects children and typically occurs following an upper resp tract infection

Symptoms

• Rash over legs and buttocks
• Abdo pain
• Joint pain
• Vomiting