Vasculitic Lesions Flashcards
What is vasculitis?
autoimmune response that leads to deposition of immune complexes in teh vessels leading to necrosis and leaking of blood into tissues, which causes skin changes
What histologic changes are seen in vasculitis?
- inflammatory cells infiltrate
- WBC attracted to the area
- leukocytoclasis (disintegration of PML’s)
- extravasation of RBC
- necrosis
- hyalinization
describe vasculitic lesions.
palpable purpura, usually!
Name the vasculitis that occurs in capillaries.
- leukocytoclastic vasculitis (LCV)
2. Henoch-Schoenlein purpura
Name the vasculitis that occurs in small arteries.
granulomatous vasculitis
Henoch-schoenlein purpura
Name the vasculitis that occurs in medium arteries.
polyarteritis nodosa (PAN)
name the vasculitis that occurs in large arteries.
giant cell arteritis
Non-palpable purpura leads you to think of what?
thrombocytopenia
coagulopathies
(if associated w/ sepsis, consider DIC)
what is the mnemonic for major etiologies of purpura?
Sleepy giant’s hen cried with pain
SLE, giant cell arteritis, Henoch-schonlein purpura, cryoglobulinemia, Wegener granulomatosis, Polyarterities nodosum
which vasculitis predominantly affects children and young adults and is preceded by pharyngitis?
Henoch-schonlein purpura
“IgA vasculitis”
which vasculitis is associated with IgA?
Henoch-schonlein purpura
“IgA vasculitis”
which vasculitis is associated with Hep B?
polyarteritis nodosa (PAN)
wegener’s granulomatosis primarily affects which organs?
lungs and kidneys
which vasculitis has a high incidence of nail fold infarcts?
wegener’s granulomatosis
which vasculitis can be diagnosed with ANCA (anti-neutrophil cytoplasmic antibodies)?
wegener’s granulomatosis
what is the most common type of primary s ystemic vasculitis?
giant cell arteritis
Diagnose this: older individuals & headache & ESR > 50.
giant cell arteritis
which vasculitis is associated with hepatitis C?
cryoglobulinemia
what is the gold standard for diagnosing vasculitis?
deep punch biopsy
which vasculitis can be diagnosed if your ASO titers come back positive?
Henoch-schonlein purpura
bc ASO is an anti-streptolysin titer that checks for exposure to Strep
what is schamberg’s disease aka?
cayenne pepper dz
what is etiology of Schamberg’s dz?
due to chronic irritant or associated with stasis dermatitis
this disease affects younger females and is worse in winter.
livedo reticularis
