Vasculature Flashcards
Veins
Carry blood to the heart very slim compared to arteries
Arteries
Carry blood away from the heart very thick compared to veins
Capillaries
Exchange I vessels
Adult humans have ___ miles of blood vessles
60,000 miles
%of blood in each system Pulmonary circulation Heart Systematic circulation -arteries -veins -capillaries
Pulmonary:18% Heart:12% Circulation:70% -arteries:13% -veins:64% -capillaries:5%
Arterioles
Very small branches off the aorta( smallest arteries)
Primary resistance vessels in system
Reduce MAP(93mmHg to 37mmHg)
Concert pulsatilla pressure to constant
Variable distribute cardiac output among organs( vasoconstriction and vasodilatation)
Vasoconstriction
Increased contraction of circular smooth muscle in the arteriolar wall which increases resistance and decreases blood flow through
Vasodilatation
Decreased contraction of circular smooth muscle in the arteriolar wall which leads to decreased resistance and increased flow of blood
Vasoconstriction triggers
Vasodilation triggers
Innervation of arterioles
Parasympathetic Innervation in penis and clitoris only!!!!
Sympathetic Innervation depending on which adrenergic receptor is expressed a1 receptors- constriction
B2 receptors- dilation
Capillaries
The exchange vessel only tunica introns .5 mm thick found every where but… Tendons, ligaments, cartilage, epithelial tissues, cornea and lens
Sphincters on capillaries aloe for the amount of blood circulating through them.
Contracted, little blood. Relaxed, full of blood
Bulk flow
Balance of inward and outward pressures determines direction of flow. Capillary blood pressure, plasma-colloid osmotic pressure, IFC hydrostatic and colloid osmotic pressure
Exchange in capillaries
Bulk flow or passive diffusion down the concentration gradient
Protein filaments in smooth muscle
Thick myosin- long
Thin actin- have tropomyosin but not troponin
Intermediate filaments- do not participate directly in contraction, part of cytoskeleton framework
What do you do to smooth muscle to activate since there is no troponin?
Must be phosphorylation by calcium
Poorly developed SR in smooth muscle… Where does ca come from?
Ca comes from ECF through voltage gated dihydropyridine receptors
Myosin kinase
Phosphorylates myosine
Myosin phosphatase
Dephosphorylates myosin
Blood pressure equation
CO=HRxSV
BP= COxPR
Total blood flow equation
Q= DP(pressure gradient)/PR(resistance)
Factors that increase total blood
Flow
Increase in cardiac output
Vasodilation( less resistance)
Factors that decrease total blood flow
Decrease in cardiac output
Vasoconstriction( more resistance)
Systolic pressure with pressure cuff
Pressure at which the sound is first heard when artery is unblocked
Diastolic pressure with pressure cuff
When sounds disappear. The brachial artery remains open
Mean arterial pressure(MAP)
MAP= diastolic pressure+pulse pressure/3
Pulse pressure= systolic pressure-diastolic pressure
When u work ou you loose blood in…
Kidney, abdominal organs, other
When you work out the blood increases in…
Brain, heart, skin, skeletal muscles
Short term blood pressure regulation
Neural circuitry
Baroreceptors