Vascular Smooth Muscle and Endothelial Cells - Endothelium

Question 1

Endothelium normally

Answer 1

Physical lining that bllod cells will not normally adhere t o

Question 2

Endothelium - inflammation

Answer 2

Leukocyte migration

Secrete NO - rednes and heat

Swelling - gaps so efflux of plasma water and Igs

Glue molecule for luekocyte capture

Question 3

Endothelial factors that relax smooth muscle

Answer 3

PGI2 - from AA via cyclooxy…acts on adneylate cyclase

NO - from L-Arg…acts on guanylate cyclase

EDHF - from AA, hyperpolarizes

Question 4

Regulation of NO

Answer 4

Agonists - thrombin, bradykinin, substance P, Ach

or shear stress from blood flow

These increase calcium which leads to NO production and thus vasodilation…opposite of smooth muscle

Question 5

Viagra

Answer 5

Inhibits breakdown of cGMP and potentiate effect of NO-mediated actions

do NOT use with nitroglyceirn

Question 6

Endothelial main fxns

Answer 6

AT2 formation

Permeability for paracellular trnaport

Inhibit platelet agg

Inflammation