Vascular Problems Flashcards

1
Q

What is the difference between arteriosclerosis and atherosclerosis?

A

arteriosclerosis: thickening/hardening of arterial wall

  • associated with aging

atherosclerosis: type of arteriosclerosis; formation of plaque within arterial wall

– both of these usually affect the larger arteries

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2
Q

What are some assessments for arteriosclerosis?

A
  • physical:
    • BP
    • pulses
    • cap refill
    • temperature of lower extremities
  • labs:
    • lipid panel
    • triglycerides
    • homocysteine
      • increased levels make cell walls more vulnerable to plaque build-up
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3
Q

What are some interventions for arteriosclerosis?

A
  • diet:
    • maintain healthy weight
    • consume variety of nutritious foods
    • cholesterol management
      • fat intake < 30% of total calories
        • < 10% from saturated fats
  • drugs:
    • HMG-CoA inhibitors (-statins)
      • reduce total cholesterol by reducing processing of cholesterol in liver and increasing clearance of LDL in blood
    • ezetimibe (Zetia)
      • absorbs cholesterol through small intestine
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4
Q

How is hypertension defined?

A

– pts without DM:

  • systolic BP greater than or equal to 140
  • diastolic BP greater than or equal to 90

– pts with DM:

  • BP > 130/90
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5
Q

What are the 5 classifications of blood pressure?

A
  • normal
    • systolic < 120
    • diastolic < 80
  • prehypertension
    • systolic = 120 - 139
    • diastolic = 80 - 89
  • stage 1
    • systolic = 140 - 159
    • diastolic = 90 - 99
  • stage 2
    • systolic = 160 - 179
    • diastolic = 100 - 109
  • stage 3
    • systolic greater than or equal to 180
    • diastolic greater than or equal to 110
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6
Q

What are the 3 types of hypertension?

A

primary (essential) HTN: HTN that does not result from another medical condition

  • causes damage to vital organs
  • causes thickening of arterioles
  • 95% of HTN pts

secondary HTN: HTN that stems from another disease process or another disorder

  • more difficult to treat
  • common causes:
    • renal disease
    • primary aldosteronism
    • pheochromocytoma – benign, non-cancerous tumor of adrenal glands
    • Cushing’s syndrome
    • medications

malignant HTN: severe, rapidly progressing HTN

  • severe problem
  • BP > 200/150
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7
Q

What are the risks for primary and secondary HTN?

A

– primary risks:

  • family hx
  • African American ethnicity
  • age
  • excessive sodium intake
  • excessive caffeine intake
  • obesity
  • smoking
  • stress

– secondary risks:

  • kidney disease
  • Cushing’s disease
  • brain tumors
  • primary aldosteronism
  • drugs:
    • estrogen
    • glucocorticoids
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8
Q

What are some assessments for HTN?

A
  • physical:
    • often asymptomatic other than h/a and dizziness
    • BP readings for both arms
    • fundoscopic examination of eyes
      • may have hemorrhages in retina
      • hard exudates
      • cotton wool spots
    • psychological assessment – stress can cause elevated BP
  • labs:
    • can determine secondary HTN
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9
Q

What are some interventions for HTN?

A
  • reduce weight
  • restrict sodium
  • consume alcohol sparingly
  • exercise
  • quit smoking
  • reduce stress
  • drugs:
    • long-acting meds are preferred
      • better compliance
      • cheaper
    • stepped therapy
    • diuretics – first line of therapy
    • calcium channel blockers
      • cause vasodilation
      • do not use in pts with HF – already compromised heart contractility
    • ACE inhibitors
      • cause vasodilation while preserving renal function
      • preferred drug for pts with HF or DM
    • angiotensin II receptor antagonists
    • aldosterone receptor antagonists
    • beta blockers (-olol)
      • decreases HR and contractility
      • causes vasodilation
      • preferred drug for pts with ischemic heart disease
      • can cause bronchospasm
        • careful with pts with asthma
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10
Q

What is peripheral vascular disease (PVD)? What is the most common location for PVD? What are some causes of PVD?

A

peripheral vascular disease (PVD): disorders that change the natural flow of blood in peripheral circulation (either arterial or venous)

  • usually implies arterial disease – more severe than venous

– most common location = legs

– causes = chronic, systemic atherosclerosis

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11
Q

What are some assessments that might indicate PVD?

A
  • intermittent claudication: leg pain that occurs following walking for a short distance
    • cramping
    • burning
    • muscle pain
    • pain at rest
    • pain worsens over time
  • hair loss on lower extremities
  • dry, pale, mottled skin
  • thickened toenails
  • rubor: redness when extremities are lowered
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12
Q

What are some diagnostic tests for PVD?

A
  • arteriography: IV contrast dye to visualize occlusions
  • doppler probe: systolic BP readings of thigh, calf, and ankle
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13
Q

What are some interventions for PVD?

A
  • exercise
    • start gradually
    • walk to point of claudication, then stop and rest
  • poistioning
    • don’t raise above level of heart
  • promote vasodilation
    • warmth to extremity
    • prevent exposure to cold
    • avoid things that cause vasoconstriction
      • stress
      • caffeine
      • nicotine
  • drugs
    • antiplatelets – increase blood flow to extremities
    • vasodilators
      • like HTN meds
  • percutaneous transluminal angioplasty
  • atherectomy: scraping of plaque from artery with a rotoblader
  • surgery
    • arterial revascularization (bypass)
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14
Q

What are the 6 P’s of arterial insufficiency?

A
  1. pain
  2. pallor
  3. pulselessness
  4. paresthesia
  5. paralysis
  6. poikilothermia (coolness)
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15
Q

What is an acute peripheral arterial occlusion? What are some interventions?

A

acute peripheral arterial occlusion: an occlusion that affects blood flow

  • most commonly caused by embolus
  • more common in lower extremities
    • may occur in upper extremities, especially in pts with IV drug addictions

– interventions:

  • drugs
    • thrombolytics
  • surgery
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16
Q

What is an aneurysm? Where are they likely to occur? What are the 4 types?

A

aneurysm: permanent localized dilation of an artery

– likely locations:

  • abdominal
    • most common
    • usually asymptomatic
    • > 6 cm = very large and severe
      • if left untreated, will rupture within 1 year
  • thoracic
  • femoral
  • popliteal

– 4 types:

  • saccular: outpouching
    • affects only a distinct area of the artery
  • fusiform: affects a lengthy surface of the artery
  • ruptured: when the aneurysm bursts
  • dissecting: accumulation of blood in the wall of the artery
17
Q

What are some signs and symptoms of aneurysm? What are some interventions?

A

– s/s:

  • limb ischemia
  • diminished/absent pulses
  • cool skin
  • pain
  • for abdominal aortic aneurysm (AAA):
    • pain in abdomen
      • steady
      • gnawing
      • unaffected by movement
      • may last for hours or days
    • pain in flank or back
    • abdominal mass with a pulse
    • rupture could be life-threatening
  • for thoracic aotic aneurysm:
    • back pain
    • SOB
    • difficulty swallowing
    • visible mass above suprasternal notch
    • sudden excruciating back/chest pain
      • indicates thoracic rupture

– interventions:

  • monitor growth
  • treat HTN
  • surgery
    • resection
      • replace an area of the vessel with a graft
18
Q

How are aneurysms diagnosed?

A
  • CT chest
  • ultrasound – will have an eggshell-like appearance
  • aortic angiography
19
Q

What is aortic dissection? What are some signs and symptoms? What are some interventions?

A

aortic dissection: a tear in the inner layers of the vessel, resulting in blood accumulating in between layers of the vessel (dissecting the vessel)

  • life-threatening

– s/s:

  • pain
    • tearing
    • ripping
    • stabbing

– interventions:

  • drugs
    • IV nitropress – vasodilator
  • surgery
    • removal of tear
    • grafting
20
Q

What is Buerger’s disease? What is it associated with? What are some diagnostic tests? What are some interventions?

A

Buerger’s disease (thromboangiitis obliterans): uncommon occlusive disease in which the vessels swelling and prevent blood flow

  • common in medium and small arteries and veins

– associated with tobacco smoking due to inflammation and vasoconstriction

– diagnostic tests:

  • CT with contrast
    • shows very little perfusion

– interventions:

  • drugs
    • nifedipine (Procardia)
21
Q

What is Raynaud’s phenomenon? What is the cause? What are some signs and symptoms? What are some interventions?

A

Raynaud’s phenomenon: condition in which the extremities feel numb or cool in response to temperature or stress

– caused by vasospasm of arteries and arterioles in extremities

– s/s:

  • numbness and coolness in extremities
  • changes in color of extremities
    • redness
    • pallor
    • cyanosis

– interventions:

  • drugs
    • calcium channel blockers
      • nifedipine
      • Cyclospasmol
      • Dibenzyline
  • surgery
    • lumbar sympathectomy
      • cutting of sympathetic nerve fibers that cause vasoconstriction in lower extremities
    • sympathetic ganglionectomy
      • cutting of sympathetic nerve fibers that cause vasoconstriction in upper extremities
  • avoid smoking
  • keep feet/hands protected and warm
  • avoid stressors
  • wear loose, warm clothing
22
Q

What is venous thromboembolism (VTE)? What population experiences VTEs more frequently? What are some risk factors for VTEs? What are some signs and symptoms? What are some interventions?

A

venous thromboembolism (VTE): clot formation and venous inflammation

– population = common in pregnant women

– risk factors:

  • pregnancy
  • varicose veins
  • venous stasis

– s/s:

  • pain in extremities
  • warmth
  • edema
  • patchy redness of legs
  • generalized weakness
  • may have weaker pulses in extremities

– interventions:

  • bedrest
  • drugs
    • antiplatelets
    • analgesics
23
Q

Differentiate between deep vein thrombosis and pulmonary embolism. How are they related? What is an important assessment to make for pts with DVT?

A

deep vein thrombosis (DVT): the most common type of thrombophlebitis (thrombus with inflammation)

pulmonary embolism (PE): a dislodged blood clot that travels to the pulmonary artery

– DVT and PE are related:

  • a thrombus from a DVT can become dislodged and cause a PE
  • 50% of pts with DVT will develop an occult PE

– ALWAYS assess for respiratory status for DVT pts for ^this reason

24
Q

What are some signs and symptoms of DVT? How is it diagnosed? What are some interventions for DVT and PE?

A

– s/s:

  • calf/groin pain
  • sudden unilateral swelling of leg
  • localized edema
  • Homan’s sign (pain with dorsiflexion of ankle)
    • NOT advised

– diagnosis:

  • venous flow studies
  • MRI
  • D-dimer
    • marker for coagulation
    • measures degradation of fibrin by-products
    • used when pt has few s/s
    • higher D-dimer and high fibrinogen = more likely to form clots and VTE

– interventions:

  • use a doppler to determine if there is occlusion
  • drugs
    • antiplatelets
      • Lovenox subq (low-molecular weight heparin)
        • preferred treatment
        • longer half-life than heparin
      • heparin bolus followed by heparin infusion
        • make sure to obtain a baseline aPTT
        • administer heparin bolus
        • begin heparin drip
        • after 6H, reassess aPTT
          • should be 1.5 - 2x baseline
      • antiplatelets will prevent aggregation and worsening of the thrombus/emboli
    • anticoagulants
      • warfarin
        • measure therapeutic effectiveness with PT and INR
      • factor Xa inhibitors (Eliquis, Zeralta)
      • Plavix
    • thrombolytics
  • surgery
    • thrombectomy
    • inferior vena caval interruption
      • insertion of a filter device in femoral vein
      • not common b/c filter legs can break off and become thromboli
25
Q

What is venous insufficiency? What are some causes? What are some signs and symptoms? What are some interventions?

A

venous insufficiency: occurs when the veins of the lower extremities prevent blood flow back to the heart

– causes:

  • prolonged venous HTN
  • stretching of veins
  • damaged valves

– s/s:

  • bilateral edema
  • stasis dermatitis
    • reddish, brown color of legs
  • stasis (venous) ulcers

– interventions:

  • management of edema
    • elevate legs above level of heart
    • compression stockings
    • intermittent sequential pneumatic pumps
  • management of venous ulcers
    • occlusive dressings – air and water-tight
    • unna boot
    • artificial skin
  • drugs
    • topicals
  • surgery
    • debridement