Vascular disorders Flashcards
systemic hyperperfusion is caused by
global cerebral ischemia
Ischemia at what area causes greatest risk of systemic hypoperfusion
Watershed zone between ACA and MCA
signs of systemic hypoperfusion
Low BP
pallor
sweating
man in a barrel syndrome
anterograde amnesia
intention tremor
nystagmus
ataxia
morphology of global cerebral ischemia at
12-24 hours
Red neurons:
eosinophilic cytoplasm
pyknotic nuclei
loss of Nissl Bodies
morphology of global cerebral ischemia at
1-3 days
Neutrophilic Infiltration
morphology of global cerebral ischemia at
3-7 days
microglia infiltration and phagocytosis
phagocytes have foamy lipid cytoplasm
morphology of global cerebral ischemia at
1-2 weeks
Reactive gliosis by astrocytes
Vascular proliferation around necrotic areas
morphology of global cerebral ischemia at
>2 weeks
Glial scaring by astrocytes
Macroscopic morphology of global cerebral ischemia at
1 week to 1 month
Liquifactive necroisis
Macroscopic morphology of global cerebral ischemia at
>1 month
Cystic cavity surrounded by a wall of dense glial fibers
What causes a stroke
focal cerebral ischemia
Types of ischemic stroke
Embolic
Thrombotic
Associations of an Embolic Ischemic stroke
Afib of the left atrium
Myocardial aneurism
Bacterial endocarditis
Atheroemboli
Cardiac shunts
Cause of thrombotic ischemic stroke
atherosclerosis
Morphology of thrombotic ischemic stroke
hyaline arteriolosclerosis
Associations of thrombotic ischemic stroke
HTN
DM
Lacunar infarcts
Presentation of hypertensive hemorrhages
Lacunar infarcts
slit hemorrhages
hypertensive encephalopathy
cause of hypertensive hemorrhage
malignant HTN
Acute Morphology of hypertensive hemorrhage
central core of clotted blood surrounded by a rim of brain tissue showing axonic neuronal and glial changes, as well as edema
Chronic morphology of hypertensive hemorrhage
- cavitary destruction with a rim of brownish discoloration
- After edema resolves, hemosiderin and lipid-laden macrophages appear eith proliferation of reactive astrocytes
Location of a pure motor lacunar infarct
posterior limb of internal capsule
location of a pure sensory lacunar infarct
VPL of the Thalamus
location of a Sensorimotor lacunar infarct
thalamus
internal capsule
caudate
putamen
pons
location of am ataxic hemiparesis lacunar infarct
base of the pons
internal capsule
location of a dysarthria-clumsy hand syndrome lacunar infarct
pons
internal capsule
slit hemorrhage morphology
slit-like cavity surrounded by a brown discoloration
focal destruction
pigment laden macrophages
gliosis
What causes hypertensive encephalopathy
malignant HTN
What does hypertensive encephalopathy cause
cerebellar dysfunction
Progressive HA
N/V
Confusion
Convulsions
Coma
Morphology of hypertensive encephalopathy
edematous brain, with or without tonsillar herniation
petechiae and fibrinoid necrosis of arterioles in the grey and white matter
Sequelae of hypertensive encephalopathy
- Muli-infarct Dementia
- Binswanger Disease
causes of Multi-infarct dementia
cerebral atherosclerosis
chronic arteriolar sclerosis
vessel thrombi/ emboli from the carotid to the heart
Morphology of Binswanger disease
large areas of white matter with myelin and axon loss
signs of multi-infarct dementia
dementia
gait abnormalities
pseudobulbar signs
Tyes of hemorrhagic stroke
intracerebral stroke (ICH)
Subarachnoid Stroke (SAH)
most common spontaneous cause of ICH
HTN
Most common cause of ICH in kids
Ruptured AVM
Most common cause of ICH in the elderly
Cerebral Amyloid Angiopathy
Associations of ICH
Coagulation disorders
CNS infection
Neoplasms
Stimulants
Traumatic injury
Etiology of SAH
Ruptured berry aneurysm
ruptured AVM
Associations of SAH
Angiomas
Neoplasms
Complications of SAH
Rebleeding
Arterial Vasospasm
Hydrocephalus
most common cause of ganglionic hemorrhages
HTN
common locations for ganglionic hemorrhages
Subcortical (Deep Brain) Regions
Basal ganglia
Cerebellar Nuclei
Thalamus
Pons
sequelae of ganglionic hemorrhage
- hyaline arteriosclerosis of small penetrating arteries
- focal damage or formation of microaneurysms
- Charcot Buchard microaneurysms
Most common risk factor for lobar hemorrhage
cerebral amyloid angiopathy
what is cerebral amyloid angiopathy
amyloidogenic peptides are deposited in the walls of medium and small meningeal and cortical vessels, which weakens the vessel wall
most common locations of lobar hemorrhage
occipital lobe
parietal lobe
Pathogenesis of a non-ruptured berry aneurysm
arterial walls lack internal elastic lamina and media, causing developmental weakness
Associations of non-ruptured berry aneurysms
Autosomal dominant polycystic kidney disease
Ehlers-Danlos
Marfan Syndrome
Neurofibromatosis Type 1
What is an arteriovenous malformation
tangled network of vascular channels in the posterior branch of the MCA
clinical presentation of AVM
young male with CHF in childhood:
seizure
ICH
SAH
cavernous malformation morphology
popcorn/ mulberry appearance
dilated capillaries with an endothelial lining
thin adventitia with no elastic fibers and smooth muscle
Clinical presentation of Cavernous sinus malformation
seizure
ICH
SAH
progressive neurologic deficits
inheritance