Vascular Flashcards
Risk Factors for DVT?
immobility
recent sx
long haul travel
pregnancy
hormone therapy with oestrogen (COCP or HRT)
malignancy
polycythaemia
SLE
thrombophilia
Examples of thrombophilias?
antiphospholipid syndrome
Factor V Leiden
antithrombin deficiency
Protein C or S deficiency
hyperhomocysteinaemia
prothrombin gene variant
activated protein C resistance
Contraindication for compression stockings?
Peripheral Arterial Disease
Presentation of DVT?
unilateral calf swelling
dilated superficial veins
calf tenderness
oedema
red, hot calf
How to examine for calf swelling in suspected DVT?
measure the circumference of the calf 10cm below the tibial tuberosity
> 3cm difference between calves is significant
Components of Wells Score?
clinical signs of DVT
tachycardia
recent sx or immobilisation
prev PE or DVT
haemoptysis
malignancy
alt diagnosis less likely than PE
Diagnosis of DVT?
d-dimer is non-specific but good rule out test if negative
Doppler US
CTPA if susp of PE
When to repeat negative Doppler US if suspected DVT?
repeat after 6-8 days if positive D-dimer and Wells score suggests DVT likely
Initial management of DVT?
anticoagulation with apixaban or rivaroxaban
consider catheter-directed thrombolysis in patients with iliofemoral DVT
Long-term management of DVT?
DOACs first-line
warfarin (antiphospholipid syndrome)
LMWH (pregnancy)
3 months if ‘provoked’ reversible cause
6 months if ‘unprovoked’ or irreversible cause
3-6 months in active cancer
IVC filter can be used
Virchow’s Triad contributing to thrombosis?
stasis of blood flow
endothelial injury
hypercoagulability
Complications of DVT?
PE
stroke (if septal defect)
chronic venous insufficiency
venous gangrene
Indications for IVC filter?
recurrent PEs despite treatment
contraindication to anticoagulation
if anticoagulation can not be used in major sx
Risks of placing IVC filter?
air embolism
arrhythmia
pneumothorax
haemothorax
IVC obstruction
bleeding
What is intermittent claudication?
muscular crampy pain brought on by exercise and relieved by rest
caused by increased demand for oxygen during exercise in the context of a reduced blood supply
What is critical limb ischaemia?
end-stage of PAD, where there is not enough blood supply for the limb to function normally at rest
typically worse at night
some relief by hanging over the edge of the bed
What is acute limb ischaemia?
rapid onset of ischaemia in a limb
due to a thrombus blocking artery
RFs for PAD?
Non-modifiable:
age
FHx
male
Modifiable:
smoking
alcohol
diet
obesity
sedentary lifestyle
poor sleep
stress
HTN
cholesterol
DM
prev stroke/MI
6 P’s of acute limb ischaemia?
pain
pallor
pulseless
perishing cold
paraesthesia
paralysis
What is Leriche Syndrome?
occurs with occlusion in the distal aorta or proximal common iliac artery
triad of:
thigh/buttock claudication
absent femoral pulses
erectile dysfunction
Signs of PAD on examination?
skin pallor
cyanosis
dependent rubor
muscle wasting
hair loss
ulcers
gangrene
poor wound healing
reduced temp
reduced sensation
positive Buerger’s test
prolonged cap refill time
What is Buerger’s test?
legs up 1 or 2 mins
pallor
hang over side of bed
blue then dark red in PAD
pink in normal
Features of arterial ulcers?
caused by ischaemia secondary to a reduced blood supply
smaller
deeper
well-defined borders
‘punched-out’ appearance
occur peripherally (toes, heels)
have reduced bleeding
painful
Investigations in PAD?
Hx and exam
ABPI
Duplex US
angiography (CT/MRI)
DDx for PAD?
spinal stenosis
osteoarthritis
nerve root entrapment e.g., sciatica
trauma
Interpretation of ABPI results?
0.9-1.2 - normal
0.6-0.9 - mild PAD
0.3-0.6 - moderate PAD
<0.3 - critical ischaemia
>1.2 - calcified arteries (DM, CKD)
Management of intermittent claudication?
conservative (lifestyle changes, smoking cessation)
medical (atorvastatin 80mg, clopidogrel 75mg, optimise medical treatment of co-morbidities)
surgical (endovascular angioplasty and stenting, endartectomy, bypass sx)
Management of critical limb ischaemia?
endovascular angioplasty and stenting
endartectomy
bypass sx
amputation if limb is unsalvageable
Management of acute limb ischaemia?
UFH infusion ASAP
endovascular thrombolysis
endovascular thrombectomy
surgical thrombectomy
endartectomy
bypass sx
amputation if limb is unsalvageable
Complications of reperfusion in PAD?
reperfusion injury
rhabdomyolysis
compartment syndrome
Causes of acute limb ischaemia?
thrombosis (acute-on-chronic)
embolic (AFib, AAA, post-MI)
trauma (compartment syndrome)
When does irreversible tissue damage occur in acute limb ischaemia?
> 6hrs of onset
What are varicose veins?
tortuous dilated segments of veins associated with valvular incompetence between the deep and superficial veins
Risk Factors for varicose veins?
prolonged standing
obesity
FHx
pregnancy
female
incr. age
DVT
Clinical presentation of varicose veins?
heavy or dragging sensation
aching
itching
burning
oedema
muscle cramps
restless leg
signs and symptoms of chronic venous insufficiency
Special Tests for varicose veins?
Tap test
Cough test
Trendelenburg’s test
Perthe’s test