Plastics Flashcards
What is a malignant melanoma?
malignant neoplasm of melanocytes
RFs for malignant melanoma?
Fitzpatrick skin type 1 and 2
pale skin, freckles, fair hair
multiple benign naevi
atypical naevi
UV exposure
FHx
personal Hx
immunosuppression
Presentation of melanoma?
ABCDE
palpable lymph nodes (may be only clinical feature)
Glasgow system of grading melanoma?
major (2 points):
change in size
irregular pigment
irregular border
minor (1 point):
diameter >7mm
inflammation
oozing, bleeding, crusting
itching, altered sensation
3 or more points needs referral
DDx for malignant melanoma?
junctional or compound naevi
cherry angioma
pigmented BCC
seborrheic keratosis
Kaposi sarcoma
Most important prognostic factor in malignant melanoma?
Breslow thickness (depth)
Subtypes of malignant melanoma?
superficial spreading melanoma
nodular melanoma
lentigo Maligna melanoma
acral lentiginous melanoma
other rare types
Features of superficial spreading melanoma?
most common type in Caucasians
70% of cases
legs for females, back for males
Features of nodular melanoma?
15-30%
more common in males on the trunk
black/brown nodule with ulceration and bleeding
poor prognosis
Features of lentigo maligna melanoma?
aka Hutchinson’s freckle
common in elderly and on face
least aggressive form
takes years before invasion occurs
Features of acral lentiginous melanoma?
5%
most common in dark-skinned population
occurs on palms and soles
can occur under nail plate (subungual)
Investigations for malignant melanoma?
excision biopsy with 2mm margin for histology
sentinel node biopsy if Breslow thickness >0.8mm
staging CT if >1mm thickness
Mx of melanoma?
WLE with margin of 1-3cm
if sentinel node biopsy positive -> lymphadenectomy
ipilimumab for mets
recurrence -> surgical excision, CO2 laser, isolated chemotherapeutic limb perfusion
radiation for palliative
What is a BCC?
basal cell carcinoma
‘rodent ulcer’
most common non-melanoma skin cancer
slow growing, mets rare, but can cause extensive local damage
What is SCC?
squamous cell carcinoma
keratin cells
second most common NMSC
higher mortality than BCC, mets more common via lymphatics
lesions on lip, ear and perineum mets early