Varicella Flashcards
Caused by HHV6 and 7 and is most common among children <3 years of age. The rash usually appears after fever has subsided.
Roseola (Exanthem subitum)
The rash initially occur on the trunk and sometimes the extremities (sparing the face) and fade within 2 days. Also known as the Sixth Disease.
Roseola (Exanthem subitum)
Known as the “slapped cheeks” exanthem which is caused by Parvovirus B19. It is most infectious before onset of rash.
Fifth disease
A 4 year old male complains of one week history of high fever, cough, and rhinitis. Bluish to white spots are also seen in the mouth. He then developed red, maculopapular rash that spreads out from the forehead to the face, neck and torso, and to his feet by the third day. What is the most likely diagnosis of this patient?
Measles (Rubeola) or First Disease
It is characterized by low grade fever, headache, sore throat, cough, conjunctivitis and lymphadenopathy. The rash is pruritic, pink to red macules and papules which begin on face and spread to neck, trunk and extremities over 24hours.
Rubella
The infectious period of varicella is from _____ until ____________.
2days before rash, all lesions crusted
All of the following are TRUE about Varicella vaccine, EXCEPT:
a. Live, attenuated VZV (Oka strain) is given
b. Given subcutaneously
c. 2 doses: 1st dose (12-15mo) and 2nd dose (4-6y/o)
d. Catch up vaccination is given at 7-12yrs old (2doses with 3 months interval)
e. Catch up vaccination is given at <13 (2doses with 4 weeks interval)
E. Catch up vaccination is given at >13 (2doses with 4 weeks interval)
There is a high risk for breakthrough disease upon administration of varicella vaccine within 4wk of MMR vaccination, therefore is is recommended to:
a. Varicella and MMR vaccines be administered simultaneously at different sites.
b. Varicella and MMR vaccines are administered subcutaneously.
c. Varicella and MMR vaccines be given at least 4 wk apart.
d. Two of the options are correct.
e. All of the options.
E. All of the options
A benign illness of childhood characterized by an exenthematous vesicular rash.
Varicella (chickenpox)
Vesicles in varicella involve the (corium/epidermis), with degenerative changes characterized by ___________, the presence of multinucleated giant cells, and eosinophilic intranuclear inclusions.
corium, ballooning
The vesicular fluid in varicella infection becomes cloudy because of the following except:
a. Recruitment of polymorphonuclear leukocytes
b. Presence of degenerated cells
c. Presence of fibrin
d. All of the above
e. None of the above
E
It is the most serious complication following chickenpox
a. Cerebellar ataxia
b. Secondary bacterial superinfection
c. Meningeal inflammation
d. Varicella pneumonia
D
Hepatic involvement in varicella is generally characterized by elevated liver enzymes, particularly _________ and ________________.
aspartate. alanine aminotransferases
It is characterized by localized pain to a dermatome with serologic evidence of herpes zoster but skin lesions are absent.
a. Zoster ophthalmicus
b. Zoster sine herpetica
c. Ramsay Hunt syndrome
d. Hodgkin’s disease
B
Tzanck smear is performed by scraping the base of the lesions, placed on a glass slide, air-dried and stained with Giemsa or Wright’s to demonstrate ______________, that suggest the presence of HSV or VZV.
multinucleated giant cells
