Ewing Sarcoma Flashcards
It is the most common primary malignant bone tumor in children.
a. Ewing sarcoma
b. Osteosarcoma
c. Rhabdomyosarcoma
d. Chondrosarcoma
B
It causes a dramatic shrinkage of the soft tissue mass and rapid significant pain relief.
Chemotherapy
It is the standard chemotherapy for osteosarcoma.
a. cyclophosphamide, etoposide, doxorubicin
b. vincristine, ifosfamide, doxorubicin
c. methotrexate, doxorubicin, cisplatin
d. doxorubicin, ifosfamide, cisplatin
C
It is a cell surface marker for Ewing sarcoma.
a. p30/32
b. p51/53
c. CD4
d. CD8
A - p30/32
It is a characteristic of Ewing’s sarcoma cells which is detected by staining with periodic acid-Schiff.
glycogen-filled cytoplasm
The classic cytogenic abnormality associated with Ewing sarcoma.
a. chromosomal amplification of region 12q13-q15
b. reciprocal translocation of the long arms of chromosomes 11 and 22
c. chromosomal anomalies in 9p21, 10, 13q14, and 17p13
d. inactivated CDKN2A which encodes tumor suppressors, p16 and p14
B
It has a predilection for metaphyses of long bones wherein the most common sites of involvement are the distal femur, proximal tibia, and proximal humerus.
a. Ewing sarcoma
b. Chondrosarcoma
c. Osteosarcoma
d. Rhabdomyosarcoma
C
The following are benign tumors of the bone of cartilage origin except:
a. osteoid osteoma
b. osteochondroma
c. enchondroma
d. chondroblastoma
A.
Common benign tumors of the bone
Cartilage origin: enchondroma, osteochondroma, chondroblastoma, chondromyxoid fibroma
Bone origin: osteoid osteoma and osteoblastoma
Fibrous tissue origin: fibroma and desmoplastic fibroma
Vascular origin: hemangioma
Unknown origin: giant-cell tumor
(TRUE or FALSE) The most common malignant tumors of bone are plasma cell tumors.
TRUE
The four most common malignant nonhematopoietic bone tumors are the following, except:
a. rhabdomyosarcoma
b. osteosarcoma
c. Ewing’s sarcoma
d. chondrosarcoma
A
UPS: Undifferentiated pleomorphic sarcoma
Based on the Musculoskeletal Tumor Society Staging System, at what stage is a bone sarcoma described as high grade and intracompartmental?
a. Stage IA
b. Stage IIIB
c. Stage IIA
d. Stage IVB
C
Musculoskeletal Tumor Society Staging System:
Stage I - low grade
Stage II - high grade
Stage III - any grade that have lymph node or distant metastases
A: intracompartmental (same soft tissue compartment as the initial tumor)
B: extracompartmental (extending into adjacent soft tissue compartment or into bone)
A radiograph finding of a destructive lesion with moth-eaten appearance, a spiculated periosteal reaction and a cuff of periosteal new bone formation at the margin of the soft tissue mass is a characteristic of:
a. Ewing sarcoma
b. Chondrosarcoma
c. Osteosarcoma
d. Rhabdomyosarcoma
C
sunburst appearance: periosteal reaction
Codman’s triangle: cuff of periosteal new bone formation at the margin of the soft tissue mass
It is used to get the image of the metastases to the bony skeleton.
a. bone scan
b. CT scan
c. FDG-PET
d. two of the options
e. all of the options
D
bone scan and fluorodeoxyglucose positron emission tomography
It is the standard management for osteosarcoma.
a. chemotherapy - limb-sparing surgery - chemotherapy
b. limb-sparing surgery - chemotherapy - radiation therapy
c. chemotherapy - limb-sparing surgery - radiation therapy
d. radiation therapy - limb-sparing chemotherapy
A
osteosarcoma is radioresistant; radiation therapy has no role in the routine management
It has a predilection for the flat bones, especially the shoulder and pelvic girdles, but can also affect the diaphyseal portions of long bones.
a. Ewing sarcoma
b. Chondrosarcoma
c. Osteosarcoma
d. Rhabdomyosarcoma
B