Valvular Diseases III Vasculitides

Question 1

Vasculitis associated with MPO-ANCA (p-ANCA) (2):

Answer 1

• Microscopic polyangiitis

- Churg-Stauss Syndrome

Question 2

Vasculitis associated with PR3-ANCA (c-ANCA):

Answer 2

Granulomatosis with polyangiitis

Question 3

Morphology of giant cell arteritis (4):

Answer 3

• Nodular intimal thickenings with reduction of the lumen
• Medial granulomatous inflammation
• Elastic lamina fragmentation
• Segmental inflammatory lesions along vessel

Question 4

Giant cell arteritis tx:

Answer 4

Corticosteroids

Question 5

Giant cell arteritis age:

Answer 5

> 50

Question 6

Takayasu arteritis age:

Answer 6

< 50 (women > men)

Question 7

Vasculitis associated with HepB (HbsAb):

Answer 7

Polyarteritis nodosa

Question 8

Polyarteritis nodosa:

Answer 8

Segmental necrtotizing inflammation of small and medium vessels

Question 9

Polyarteritis nodosa usually spares:

Answer 9

Lungs

Question 10

Polyarteritis nodosa treatment:

Answer 10

corticosteroids and cyclophosphamide

Question 11

Number 1 cause of acquired heart disease in children:

Answer 11

Kawasaki syndrome

Question 12

Kawasaki syndrome tx:

Answer 12

ASA and IVIG

Question 13

Microscopic polyangiitis treatment:

Answer 13

Immunosuppression

Question 14

Churg-Strauss syndrome:

Answer 14

Small vessel necrotizing vasculitis

Question 15

Churg-Strauss syndrome is associated with (3):

Answer 15

• Allergic rhinitis
• Bronchial asthma
• Eosinophilia

Question 16

Granulomatosis with polyangiitis triad (3):

Answer 16

• Acute necrotizing granulomas of upper and/or lower airways
• Focal necrotizing or granulomatous vasculitis of small to medium-sized vessels in lungs/airways
• Renal disease

Question 17

S/S of granulomatosis with polyangiitis (4):

Answer 17

• Persistent pneumonitis with bilateral nodular and cavitary infiltrates
• Chronic sinusitis
• Mucosal ulceration of the nasopharynx
• Evidence of renal disease

Question 18

Tx of granulomatosis with polyangiitis:

Answer 18

Cyclophosphamide

Question 19

Thromboangiitis is associated with:

Answer 19

Heavy smokers