Antihypertensives Flashcards
Recommended for isolated systolic HTN in elderly:
Thiazide diuretics
Thiazide diuretic considerations (2):
- Avoid in gout
- Avoid in DM
Thiazide drug interactions (4):
- Digoxin (hypokalemia)
- Quinidine (hypokalemia –> torsades)
- NSAIDS (inhibit antihypertensive effect)
- Antidiabetics (hyperglycemia)
Loop diuretic use in HTN (2):
- Anithypertensive diuretic when GFR < 30 ml/min
- Used to combat massive fluid retention induced gy vasodilators
Treatment for HTN due to primary hyperaldosteronism:
Spironolactone
Compelling indications for ACEI use (3):
- DM
- CHF
- Post-MI with systolic dysfunction
Beta-blockers in HTN (3):
- Decrease mortality in HTN
- Recommended for initial therapy
- Compelling indication for use with post-MI and CHF
Drug interactions with beta-blockers (3):
- NSAIDS (inhibit antihypertensive effect)
- Digoxin (decrease AV conduction)
- Verapamil, diltiazem (decrease myocardial contractility, decrease AV conduction)
Treatment of HTN during pregnancy:
Methyldopa
Centrally-acting alpha2 agonists (2):
- Methyldopa
- Clonidine
Adrenergic neuronal blocking agent:
Reserpine
- Not recommended for initial therapy
Vasodilators used for HTN are usually combined with:
Diuretic +/- beta-blocker
More effective in blacks than ACEIs or beta-blockers:
Calcium channel blockers
Avoid CCBs (3):
- Avoid short-acting DHPs (increase mortality)
- Avoid verapamil, diltiazem in CHF (decrease myocardial contractility)
- Avoid verapamil, diltiazem in 2nd/3rd degree AV block (decrease AV conduction)
Potassium channel opener:
Minoxidil
