Valproic Acid ADME Flashcards
S value for all dosages of valproic acid salt forms
1
Is valproic acid completely absorbed?
Eh…it almost is
The rate of absorption for valproic acid depends on what?
The dosage form
Food and valproic acid absorption
Food can decrease the rate of absorption but not the extent to which it’s absorbed
Valproic acid and diurnal variations
Can result in nighttime concentrations that are ~40% of the daytime dose
Vd for VPA
Relatively small
VPA concentrations in CSF
Tend to be lower than unbound serum concentrations
Can VPA distribute into breastmilk?
Yes
VPA protein binding with a dose increase
Saturable with an increase in dose
Where is VPA primarily eliminated?
Liver
Is VPA a low or high extraction drug?
LOW
What kind of changes does VPA experience?
It exhibits concentration-related changes in apparent CL, with higher CL at higher concentrations
A higher apparent PO CL of VPA at higher concentrations exhibits what kind of changes?
Concentration-related changes; higher CL at higher concentrations
Co-administration of VPA with other highly protein-bound drugs may result in what?
Protein-binding displacement interactions
Minimum effective trough concentration of VPA
40-50mg/L
