Carbamazepine ADME Flashcards
Does carbamazepine go through first pass metabolism?
Nope
True or false: the rate of carbamazepine absorption can vary between formulations.
True
What can happen to the drug concentrations of carbamazepine and why does it happen?
Secondary peaks can occur because of a slow but constant rate of absorption happening in the upper and lower intestines
What kind of absorption does carbamazepine experience?
Saturable
Carbamazepine undergoes what at the same time?
First-order and zero-order absorption
Carbamazepine storage conditions
Cool, dry place
Primary route of elimination of carbamazepine
Hepatic metabolism via the CYP3A4 enzyme system
Distribution of carbamazepine to the body
Distributed rapidly and uniformly to organs and tissues, rapidly crosses the placenta
What does carbamazepine bind to?
Albumin and AAG
Active metabolite of carbamazepine
Carbamazepine-10,11-epoxide
What can carbamazepine do? (in terms of its metabolism)
Induce its own metabolism- autoinduction
The ratio of Css of metabolite and parent drug and daily dose of parent drug can be explained by what?
(Imagine the graph that’s like kind of a curve lol idk)
Linear, stationary kinetics of metabolite formation and saturable, nonlinear kinetics of metabolite elimination
Autoinduction of metabolite formation and linear, stationary kinetics of metabolite elimination
The ratio of Css of metabolite and parent drug and daily dose of parent drug can be explained by what?
(Imagine the graph that’s like almost a straight line)
Linear, stationary kinetics of metabolite formation and linear, stationary kinetics of elimination CL of the metabolite
Carbamazepine and circadian variation
Circadian rhythms can affect the rate of absorption
