Vaccines Flashcards
1
Q
why is it difficult to create parasite vaccines
A
They are eukaryotic infections
- complex life cycles
- complex antigens
2
Q
what was the 1st vaccine to be developed
A
lungworm vaccine in cattle
dictyocaulus viviparus
cattle coughs and spreads it or ingests it
3
Q
How was lungworm vaccine developed?
A
Gving L3 larvae a dose of radiation
they don’t complete life cycle, they grow to L4 then die
4
Q
What is the name of the malaria vaccine used in southern mozambique
A
RTS
used children
combined 19 copies of tetropeptide NANP with hepatitis B antigen
vaccine includes high levels of CS repeat specific antibody and IFN-y production
5
Q
What vaccine was made off the back of RTS
A
R21
simplified version
75% protective efficacy against clinical malaria
6
Q
A
