Vaccine Adjuvants

Question 1

Example TLR Agonist Adjuvant

Answer 1

LPS Lipid A

Question 2

Three types of adjuvant

Answer 2

Depot effects, delivery vehicles, Immune stimulators

Question 3

Depot Adjuvants

Answer 3

Sequester antigen at infection sites, longer exposure

Question 4

Example Depot adjuvant

Answer 4

Aluminium salts - gel-like matrix

Liposomes - encapsulate antigen

Question 5

Delivery vehicles

Answer 5

Target antigen immune cells

Question 6

Example Delivery adjuvants

Answer 6

Particle delivery systems - attach to particles taken up by APCs
Liposome delivery - deliver antigens to cells

Question 7

Extra reading - adjuvant example

Answer 7

Reddy et al 2007 - Nanoparticle antigen delivery, induce complement

Question 8

TLR Agonist

Answer 8

Immune stimulator, activate MyD88 and TRIF
Produce cytokines, chemokines and interferons, activate CD4 and CD8
Activate APCs to present antigen