Research

Question 1

First described structure of antibodies? When did they win the nobel prize?

Answer 1

Porter and Edelman, sharing nobel prize for physiology and medicine in 1972

Question 2

Reichenberger 2002

Answer 2

Aspergillus fumigatus spores inhibit transcription factors incl. NFKB, reducing production of TNFalpha and IL1
Pro-inflammatory cytokines

Question 3

Saxena et al 2018

Answer 3

New research vaccines
Dendritic cell vaccines first proposed preclinically in 1990s
Sipuleucel-T, DC-based anti-tumour vaccine approved by FDA in 2015 for certain prostate cancers

Question 4

Ramanathan 1979

Answer 4

First use of aluminium adjuvants, demonstrating complement activation

Question 5

Reddy 2007

Answer 5

New research adjuvant
Nanoparticle antigen-delivery adjuvant
Induces complement

Question 6

Katz 2011

Answer 6

Cancer mAb treatment
Brentuximab - mAb treatment for Hodgkin Lymphoma
Targets CD30 antigen on lymphocytes

Question 7

Chaturvedi 2005

Answer 7

Fungal mAb treatment
mAb A9 - mAb treatment for A Fumigatis
Binds cell wall glycoprotein of A Fumigatis - Inhibits hyphal development

Question 8

Bugli 2013

Answer 8

Fungal mAb treatment

Mycograb - Binds candida HSP(90) antigen

Question 9

Heldt 2017

Answer 9

Fungal mAb diagnostic
Point of care diagnostics - lateral flow device
Aspergillus specific - JF5Ab
Urinary-excreted galactomannan-like antigens