UWOrld wrong questions part3 (3rd 200 q's) Flashcards
a) Gold standard of treatment of hot flashes? b) Tx in woman with breast cancer hx? c) with depression? d) with HTN? e) with insomnia/seizure/pain?
a) estrogen b) Desvenlafaxine or SSRI; c) venlafaxine d) clonidine e) gabapentin
what neuro problem is absolute contraindication to OCP use?
migraine with aura
what meds reduce effectiveness of combo OCPs?
RIFAMPIN! also, Guinness, Coronas, & PBRs induce chronic alcoholism: Griseofulvin, Carbamazepine, Phenytoin, Barbs, Rifampin, St Johns Wort, Chronic alcoholism
avoid progesterone IUD if you have what?
breast cancer
OCP use decreases incidence of what types of cancer?
ovarian, endometrial, colon; (NOT breast)
pulmonary cause of a) decreased PaO2 / increased PaCO2 vs b) decreased PaO2 / decreased PaCO2?
a) resp acidosis from alveolar hypoventilation, COPD, OSA, NM diseases like Lambert Eaton, Guillian-Barre, and Myasthenia gravis b/c all of these relate to KEEPING CO2 IN———- b) resp alkalosis from ANYTHING that would cause increased RR (thus blowing off CO2): atelectasis, PE, pleural effusion, pulm edema (all V/Q mismatch!!)
how to tell diff btwn esophageal perforation and aortic dissection? Next step in management, Tx for esophageal perf?
Esoph perf: mediastinal air (pneumomediastinum), pneumothorax. Dx with water soluble Gastrografin (NOT barium) contrast esophogram. Tx: broad Abx + supportive care unless significant leak.————- Aortic dissection: decreased BP, hemothorax, Dx with TEE.
succussion splash on epigastrium (placing stethoscope here and rocking patient back and forth at hips)indicates what?
gastric outlet obstruction (tumor, PUD, Crohn, strictures, caustic agents, bezoars) b/c this is sound of retained gastric material >3 hrs after meal.
ingestion of acid can cause what anatomical problem?
pyloric stricture (type of gastric outlet obstruction)
main signifier Sx of atelectasis?
shallow breathing (with increased RR, causing decreased CO2) 2-5 days after surgery
COPD and pneumothorax: what tactile fremitus, breath sounds, and percussion?
decreased tactile fremitis, decreased breath ounds, and hyperresonant to percussion
bronchial breath sounds/”bronchophony”/egophony, etc, think what lung issue?
consolidation – lobar pneumonia
pleural effusion: what is tactile fremitus, breath sounds, and percussion in this patient?
decreased tactile fremitus, decreased breath sounds, and dull percussion. Also, mediastinal shift away from effusion IF large.
bleeding varices: 1st, 2nd, and 3rd line of management?
1st: IVF, Abx, octreotide. —2nd: endoscopy within 12 h with sclerotherapy or band ligation —- 3rd: If no further bleeding, give BB + endoscopic band ligation 1-2 w later. If continued bleeding, temp balloon tamponade with eventual TIPS/shunt surgery.
the 2 main atypical signs of a massive PE? Tx?
hypotension (causing syncope) and right heart strain (causing JVD, R BBB, bradycardia). Tx: thrombolytics
what should be done in workup of achalasia?
Barium study, then manometry to confirm, plus endoscopy to r/o tumor/cancer at GE juntion
After doing physical, measuring hCG, TSH, & all hormones for amenorrhea and they turn out normal, what do you do next in workup and what does it mean?
Progesterone challenge. Give 5-10 days of progesterone, withdraw, and if she bleeds this means estrogen is normal (b/c endometrial lining was built up). If no bleeding, then low estrogen. ———— Next do estrogen-progesterone challenge and if this fails there’s an anatomical defect.
Next step if physical exam shows absence/difficulty finding uterus? 2nd step?
pelvis U/S. then karyotype and testosterone.
2 possibilities of Dz if uterus is absent?
1) Androgen insensitivity syndrome: 46XY, normal outer female development but with testes/male internals and elevated testosterone.————–2) Abnormal mullerian development: 46XX, normal outer female development but missing female internals and normal female testosterone levels.
Patient with amenorrhea – if uterus is present, what is next step? Step after that?
b-hCG and FSH. —–>Then if FSH is high do karyotype for Turner syndrome. If FSH low do cranial MRI. If FSH is normal, do prolactin and TSH.
amenorrhea in patient who had D&C might be what? Tx?
Asherman syndrome (scarring of ovaries from surgery) - do progesterone withdrawal test. Tx: lysis of adhesions + estrogen
Dix-Hallpike manuever diagnoses what? Tx?
Benign Paroxysmal Positional Vertigo. Tx: Epley maneuver
dysmenorrhea: workup? Tx?
b-HCG, vag culture, U/A. Tx: NSAIDS, OCPs
Dysmenorrhea, dyspareinua, and dyschezia (painful defecation during menses), tender adnexal masses=? Dx? Tx?
endometriosis. Dx: Bx (CA-125 too general). Tx: NSAIDS, OCPs, GnRH agonist continuous, progestin // if fertility desired, lap surgery or hysterectomy WITH B/L salpingo-oopherectomy
Patient with GERD Sx - what is 1st and 2nd step in management?
1st: if alarm sx (dysphagia, weight loss, blood, recurrent vom) or >55 then endoscopy, if esophagitis do H pylori test then Tx, if no esophagitis workup for other things like with manometry.———————— If no alarm Sx then once daily PPI for 2 months. 2nd step: if refractory switch to diff PPI or increase to 2x daily, if not working 3) do endo/pH monitoring.
Tx for cholecystitis for patients who do not want lap chole?
Tx: ursodeoxycholic acid + avoid fatty foods
aortic stenosis murmurs or ESRD + anemia + painless GI bleeding in patient >60 = what? Dx?
angiodysplasia (or AV malformations) of GI tract. Dx: colonoscopy or capsule endoscopy.
increased direct bilirubin in adult after illness + normal LFTs + dark granular pigment in hepatocytes on liver Bx = ?
Dubin Johnson syndrome. (if no pigment, then might be Rotor syndrome)
Carcinoid syndrome - what heart abnormalities? Dx? Tx?
valvular lesions (R>L). Dx: 5-HIAA, CT/MRI of abd/pelvis, octrescan, echo. Tx: octreotide for Sx; surgery for liver mets.
Tx for duodenal hematoma causing obstruction?
NG suction with parenteral nutrition. After 1-2weeks, Laparotomy/laparoscopy if this fails.
After finding gastrin level for working up ZE syndrome, what is next step? 3rd step?
If >1000, check gastric pH off PPIs for 1 week. If >4, no gastrinoma. If
a) Irregular,heavy periods suggest what? b) regular, heavy periods suggest what?
a) anovulation. b) anatomic (adenomyosis, fibroids, etc)
abnormal uterine bleeding - what workup after labs and cultures?
if >45 OR 6months, endometrial Bx. U/S pelvis; hysteroscopy.
abnormal uterine bleeding with depression, constipation, think = ?
hypothyroidism
abnormal uterine bleeding started with menarche, think = ? What are lab values?
von Willebrand Dz (increased bleeding time and PTT)
abnormal uterine bleeding in unstable patient, do what?
IVF, RBCs, intrauterine tamponade(balloon to decrease bleeding), uterine curettage. If persists —> IV high dose estrogen + antiemetic
cirrhosis or asciites + fever or change in mental status, think = ? Dx?
spontaneous bacterial peritonitis. Dx: paracentesis (BEFORE Abx) showing PMNs >250.
nonbleeding esophageal varices, how to Tx?
nonselective BBs(propranolol, nadolol); endoscopic variceal ligation if BBs contrindicated
decreased total T3 and T4, but normal free T3 and T4, normal TSH = ?
liver disease (because liver makes thyroxine-binding proteins)
acute cholangitis, what is 1st, 2nd, and 3rd step of management?
1st: IVF, broad Abx. —>2nd (if not better): biliary decompression/drainage by ERCP. 3rd:(eventual) cholecystectomy
diangosis of diverticulitis?
abdominal CT (NOT upright film/XR; NEVER -scopy)
diagnose someone with Hep C, what is 1st step in management? 2nd step? 3rd step/
1st: Liver Biopsy to stage.(b/c meds will only help if not yet cirrhotic)—— 2nd:INF, ribavirin. ——–3rd: U/S every 6 months for HCC surviellance
how to diagnose pancreatic cancer if with jaundice vs not jaundice?
Jaundice: abd U/S. ———-No jaundice: abd CT
(+) progestin challenge, LH:FSH >2:1, anovulation, increased T = ?
PCOS (need 2 of 3: anovulation, cysts on U/S, hyperandrogen Sx)
best drug for PCOS to improve fertility?
clomiphene
most common causes of steatorrhea?
chronic pancreatitis due to alcohol abuse>CF>other pancreatitis, Crohn’s, Celiac (but NOT lactose intolerance)
when to admit patient for CAP?
2 or more of the following: age>65, RR>30, hypotension, uremia(BUN>20), confusion
a)How to treat CAP outpatient? b) CAP inpatient non-iCU? c) CAP inpatient ICU?
a) macrolide or doxy (unless they mave comorbid, then just like inpatient non-ICU)————-b) FQ or b-lactam + macrolide ——————–c) b-lactam + macrolide(IV) or b-lactam + FQ
when do you put chest tube(aka tube thoracostomy) for parapneumonic effusion?
empyema: when pleural fluid pH
large anterior mediastinal mass with increased AFP and b-HCG in young man = ?
nonseminomatous germ cell tumor
what mass tends to be located in anterior mediastinum? middle mediastinum?
anterior: thymoma. Middle: bronchogenic cysts
what disease has transiently elevated LFTs over time, porphyria cutanea tarda, essential mixed cryoglobulinemia (circ Ig’s deposit in vessels, low serum complement)
hep C
a) erosions on dorsum of hands = ? b) painful nodules on anterior legs = ? c) necrotizing vasculits with rash from Ag-Ab immune complexes = ?
a) porphyria cutanea tarda (with hep C) . b) erythema nodosum (with infections/sarcoid) c) polyarteritis nodosa (with hep B)
symmetric, circumferental narrowing of esophagus with dysphagia for solids only, no weight loss? associated/causal disease?
Esophageal (peptic) stricture. Caused by GERD (or radiation, systemic sclerosis, and caustic ingestions).
Diagnostic test of choice of Zenker diverticulum?
contrast esophagram
after getting abnormal quad screen, what is next step? step after that?
1) U/S to confirm dating, etc. 2) definitive diagnosis: CVS[10-13 wks] or amniocentesis. [15-20 weeks]
What does increased ACh indicated in amniocentesis?
neural tube defects
diff between quad screen results of Down and Edwards and Patau?
Down: decreased AFP, decreased estriol, increased b-hCG, increased inhibin. / Edwards: decreased AFP, decreased estriol, decreased b-hCG, decreased inhibin (ALL DECREASED) / Patau: only decreased AFP.
Best anti-nausea meds for morning sickness?
pyridoxine (vit B6) + doxylamine (anti-hist)
when do you do screening for gestational diabetes? How do you diagnose?
24-28 wks. 50g 1 hr oral glucose tolerance test, then if (+) do 100 g 1,2,3hr oral glucose tolerance test. If 2+ of these test results are positive, it is diagnosed,
what do you do for pregnant patient with bacteria/WBCs in urine and no Sx?
this is Asymptomatic bacteruria, but must prevent from causing UTI/pyelo. Tx: nitrofurantoin, amoxicillin, cephalexin, fosfomycin, or TMP-SMX. repeat urine culture 1 wk after finishing Abx.
how to treat pyelo in pregnant patient?
ADMIT, then IV amp + genta, ceftriaxone, meropenem, or piper-tazo. Continue oral Abx for rest of pregnancy.
when to get pap smears for normal patients?
start at age 21, every 3 years till 29. 30+ can continue q3 or pap + HPV testing q5. Stop at 65.
Treatment for squamous cell carcinoma of vagina?
Stage I & 2cm: external beam radiation————– Stage II, III, IV: external beam radiation + therapy
how to treat lichen sclerosis?
punch biopsy to r/o SCC; steroids
Thayer Martin media is for what?
culture for gonorrhea
how to treat PID as outpatient? inpatient?
Outpt: ceftriaxone, doxy, or metro. / Inpt: IV cefotetan + doxy, or IV cefoxitin + doxy.
how to treat granuloma inguinale? How to distinguish it from other ulcerating STDs? what microorganism?
doxycycline. no lymphadenopathy, . From Klebsiella granulomatis.
If you have ASCUS on pap, what is next step?/
If 21-24 yrs, repeat pap in 1 year -> if repeat is (+), do colpo. ———–If 25+, do HPV testing->if (+), do colpo.
If “atypical squamous cells: cannot exclude high grade SIL” on pap, what is next step?
colposcopy
If AGUS(atypical glandular cells of undetermined signficance) on pap, what is next step?
endocervical sampling, colposcopy, & endometrial Bx if >35 or risk factors.