Diabetes Medication Flashcards
Diabetes meds with no weight gain
metformin, DPP-4(-gliptin), GLP-1(-tide), SGLT-2(-flozin)
metformin: s.e.
GI upset, lactic acidosis, decreased B12 (give supplements)
metformin contraindications
increased Cr / kidney disease; any severe, chronic disease
Diabetes meds good for patients with kidney problems
TZDs (-glitazone), acarbose, DPP-4(-gliptin), GLP-1(-tide)
glimepiride, glipizide, glyburide: group, MoA
sulfonylureas: stimulate insulin release from beta cells by activating K+
glimepiride, glipizide, glyburide: s.e.
hypoglycemia, weight gain (sulfonylureas)
glimepiride, glipizide, glyburide: contraindications
hepatic/renal insufficiency, bad pancreas from long-standing DM
what drugs decrease gluconeogenesis in liver and increase insulin sensitivity?
metformin, TZDs (-glitazone)
roziglitazone, pyriglitazone: s.e.
weight gain, fluid retention, pulm edema and CHF exacerbation (TZDs)
roziglitazone, pyriglitazone: contraindications
CHF above stage III, liver dysfunction (TZDs)
dapagliflozin, nagliflozin: type, MoA
SGLT-2 inhibitors: increases glucose in urine by blocking transporter that reabsorbs glucose
dapagliflozin, nagliflozin s.e. / contraindications
UTIs / AKI (SGLT-2 inhibitors)
sitagliptin, alogliptin, linegliptin, saxagliptin: type, s.e.
DPP-4 inhibitors / none! just not very effective
what drugs decrease glucagon secretion, increase insulin secretion, and delay gastric emptying?
DPP-4 inh(-gliptin), GLP-1 agonists (-tide)
exenatide, liraglutide, diraglutide: type, s.e.
GLP-1 agonists / nausea and WEIGHT LOSS
