UWorld wrong questions part 1 (1st 200 qs) Flashcards
What vitamin deficiency accompanies carcinoid syndrome?
niacin (b/c 5-HT is made from tryptophan which also makes niacin)
4 diagnostic things to do with carcinoid syndrome
24 hr urine with 5-HIAA, CT/MRI abd/pel, metastasis scan, echo
proximal muscle weakness + weight loss, anxiety, tremor with movement, tachy = think…
hyperthyroidism
Causes of proximal muscle weakness
poly/dermatomyositis, hypo/hyperthyroidism, Cushing’s, Lambert-Eaton, myasthenia gravis, steroids
suspect MEN syndrome: what do you do to screen and treat?
screen: genetic testing
treat: total thyroidectomy
what drug decreases frequency of acute relapse in MS?(for relapsing-remitting)
IFN-beta
what drug should be given DURING acute flare of MS?
high dose steroids
what drugs treat progressive form of MS?(one with no remissions)
immunosuppressants: cyclosporine, methotrexate, mitoxantrone
1st step in diagnosing/managing MS? 2nd step?
MRI of brain w/ w/o gadolinium, showing demyelinated plaques (SECOND step = IgG on CSF)
Extrapyramidal side effect of restlessness = ? treat with?
Akathisia. Benzo
Extrapyramidal side effect of tremor, rigidity, slow movements = ? treat with?
Parkinsonism. no Tx.
Sudden sustained contraction of neck, mouth, tongue, eyes = ? Treat with?
Acute dystonia. Benztropine or diphendydramine
adrenal insufficiency signs + hyperpigmentation, increased K, decreased Na, decreased BP = ?
primary insufficiency (so decreased cortisol, increased ACTH, decreased aldosterone)
best preventative measure to do to reduce chances of peripheral neuropathy with diabetes?
blood pressure control
diff between VIPoma and carcinoid syndrome?
VIPoma tumor in pancreas, carcinoid tumor in SI. also decreased H, Cl, and K in VIPoma
increased T3, T4 and normal TSH = ?
resistance to thyroid hormones. have hypothyroidism signs
loss of pain/temp over ipsi face & C/L body, ipsi dysphasia/hoarseness(CN IX/X), vertigo, nystagmus, Horner’s = what disease, localized where in brain? Tx?
Wallenberg syndrome (lateral medullary infarct). Tx: t-PA
Weakness of jaw, decreased sensation on face = what neuro area infarct?
Lateral pons infarct = more sensory issues. / medial pons = more motor issues
C/L arm/leg paralysis, tongue deviation toward lesion = what neuro area infarct?
Medial medullar infarct
Patient with Parkinsonism experiences: orthostatic hypotension + autonomic dysfunction (i.e. bladder probs, ED, cholinergic signs) + neuro signs? Tx?
Shy Drager syndrome (Multiple System Atrophy). / Tx: fludrocortisone, salt, alpha-adrenergic agonists, constrictive garments
child with autonomic dysfunction and orthostatic hypotension, think what aut dom disease?
Riley Day Syndrome (Ashkenazis_
brain death = what is still functioning?
spinal cord, so DTRs present. NO brainstem fxn (no HR, no breathing, etc)
intention tremor found with what disease?
alcoholism –> cerebellar degeneration
lab values in secondary hyperparathyroidism? (PTH?Ca?PO4?D?)
increased PTH, decreased Ca, increased phosphate, decreased vit D
increased Ca+2 labs; next 2 steps?
Repeat Ca, THEN measure PTH
if hypercalcemia + increased PTH, consider what?
primary and tertiary hyperpara, familial hypercalcemic hypocalcuria, lithium
if hypercalcemia + decreased PTH, consider what?
malignancy, vit D tox, gramulomas, HCTZ/theophylline, thyroxic, vit A tox, immobilization
3 steps to take in management when suspecting acromegaly?
IGF-1 –> oral glucose suppression —> MRI of brain (pituitary?)
where can median nerve entrapment occur?
wrist (loss of motor and sensory) > mid-forearm > elbow (sensory spared)
lacunar infarct will cause what Sx?
U/L motor impairment (b/c posterior limn of internal capsule); no sensory deficits
lesion of optic radiation causes
contralateral hononymous hemianopia
oculomotor nerve lesion causes
ptosis and eye looking down and out (unopposed IV and VI)
trochlear nerve lesion causes
vertical diploplia and extorsion of eye
lesion on medial lemniscus causes
decreased touch and vibration sensation
what withdrawal symptoms happen from abrupt discontinuation of benzos?
seizures
what is first line treatment for OCD?
SSRIs + clomipramine (TCA)
what med to treat anorexia with if no response to CBT?
olanzapine
Cushingoid Sx - steps in management?(4)
1st get 24 hr cortisol / low dose dexa sup test. 2nd get ACTH level. 3rd get imaging based on where it is(adrenal/head MRI?). 4th get IPSS/full body imaging/high dose dexa for ectopic source
Addison Sx - how to diagnose?
after cortissol levels, do Consyntropin stimulation test (analog of ACTH) - if no increase in cortisol it’s primary
Parkland burn formula - how much IVF to give?
4 mL x kg x %BSA, then give first 1/2 first 8 hrs, 2nd half next 16 hrs
When to admit burn patient inpatient and do IVF, escharotomy?
2nd degree with >10% BSA, 3rd degree with >2% BSA, or involving face/hands/genitalia/skin flexure areas
glucose suppression test used for what?
confirmatory diagnosis of acromegaly (after iGF-1, which is 1st step in management)
differences in Ca and PO4 with primary vs secondary hyperparathyroidism?
primary: increased Ca, decreased PO4. secondary: decreased Ca, increased PO4.
feel palpable thyroid nodule, what are next steps in management?
1st get TSH, T4, U/S. 2nd: if hypo or euthyroid, get FNA. If hyperthyroid, do radionucleotide iodine uptake scan. If hot treat hyper. If cold, FNA.
For diabetics, when to do a) physical exam w/ glucose, b) urine microalbumin, U/A, CMP c) lipid panel, d) ophtho visit e) what vaccines
a) 3-6 months dep on HbA1C, b) yearly, c) yearly d) yearly e) flu and pneumo
if you see microalbuminuria in DM patient, what next?
24 hour urine protein to look for nephrotic syndrome
what is neovascularization on fundo exam and how is it treated?
Proliferative DM retinopathy: treat with laser photocoag
J waves on EKG = ?
hypothermia (bump after QRS)
How to treat scorpion sting?
atropine (antichol), antivenin, phenobarbitol
How to treat brown recluse spider bite?
debridement, dapsone. if infection, oral erythromycin.
If dirty/punctured/crush wound, do what tetanus stuff?
Td if > 5 years since last dose and equal to or more than 3 prior immunizations, Td + tetanus Ig if less than 3 prior immunizations
Do not do exercise stress test if…
L BBB, LVH (do nuclear & pharm)
gold standard for CAD?
coronary angio (after 1st step: stress test shows ischemia, angina, or greater than 1 mm ST depression)
chlorpromazine, prochlorperazine, or metoclopramide are hat kinds of drugs, and can be used with NSAIDs or triptans for what?
antiemetics, for migraines
migraine PPx drug?
beta blocker
what antipschotic is associated with QT prolongation and thus you should do ECG?
ziprasidone
what second gen antipsychotic comes with hyperprolactinemia?
risperidone
antipsychotics with highest risk of weight gain/llipid/glucose increase?
olanzapine, clozapine
how to tell malignant hyperthermia from thyroid storm?
malig hyperthermia: muscle rigidity, hyperkalemia. thyroid storm: lid lag, arrythmmias, tremor, goiter. BOTH can occur after surgery.
How to treat thyroid storm?
PTU, iodine, beta blocker for Sx, glucocorticoids for creasing T4 to T3 conversion
B/L LE weakness, UMN signs, think
spinal cord compression (UMN = CNS), B/L = spinal cord and not brain
what is trihexyphenidyl?
anticholinergic, often used for Parkinson’s
essential tremor is what? how to treat?
worsens with activity (OPPOSITE of Parinsonian kind) Primidone + beta blocker. (2nd line = benzos, clozapine)
painless curtain over eye, CAD = what?
amaurosis fugax = loss of vision from emboli, shows stroke is coming. Do Duplex U/S of neck – most common site.
levodopa + carbidopa: s.e.
somnolence, confusion, hallucinations in order patients
amantadine: s.e.
ankle edema, livedo reticularis
apomorphine, bromocriptine, pramipexole, ropinirole: s.e. (Parkinsonian drugs)
somnolence, confusion, hypotension, hallucinations in older patients (these are dopamine agonists)
entacapone/tolcapone: type, s.e. (Parkinsonian drugs)
COMT inhibitor. Dyskinesia, hallucinations, confusion, N, hypotension
selegiline: type, s.e.
MAO-B inhibitor. insomnia, confusion
treatment for prolactinoma: 1st, then 2nd
capergoline>bromocriptine, then Sx if it fails
what is diagnostic of MS?
MRI brain (not LP- IgG bands, b/c this only exists in 90% of pts)
treatment for Paget’s disease?
bisphosphonates if symptomatic
Patient with HTN & hypokalemia, suspect hyperaldosteronism. 1st step in management? 2nd? 3rd?
1) aldosterone/renin ratio. (primary vs secondary)
2) if increased, do adrenal suppression tests (if +, then adrenal imaging)
Type of gait in Parkinsonism?
hypokinetic (slow, shuffling, narrow, immobile arms)
waddling gait is in what?
muscular dystrophy (weak gluteals)
spastic gait is in what?
UMN lesions or cerebral palsy
wide-based, high stepping gait is in what?
sensory ataxia (because loss of proprioception) – Romberg +. Wide is also in MSA, multiinfarct.
how to tell apart lacunar infarct vs MCA vs ACA?
lacunar: U/L motor impairment. MCA: C/L sensory & motor face, arm, leg, homonymous hemianopia, eye deviation twd infarct, aphasia/hemineglect. ACA: same as above but in LE only.
1st and final diagnosis of prinzmetal angina?
1st: stress test (ST elev during pain sx only). Final diagnosis: coronary arteriography showing NO stenosis
1st line treatment of prinzmetal angina?
CCB (NOT beta blocker)
when to do CABG?
> 50% stenosis in LAD, 3 vessel disease, or CAD + DM
when to do fibrinolysis?
STEMI, NOT unstable angina
what to give in a propanolol OD?
glucagon, Ca, insulin + dextrose
what is a diagnostic glucose level for DM?
random >200 + DM symptoms OR fasting >126 on two occasions
narrow QRS, HR >100, healthy young patient
paroxysmal SVT. This includes WPW & AV nodal reentry. [v. tachy = wide QRS!)