UW quick stones

Question 1

Hypercholesterolemia?

Answer 1

Increased cholesterol synthesis.

Cholesterol stones.

Question 2

diabetes mellitus?

Answer 2

Increased cholesterol synthesis.

Cholesterol stones.

Question 3

medications (eg, oral contraceptives)?

Answer 3

Increased cholesterol synthesis.

Cholesterol stones.

Question 4

obesity (increased HMG-CoA reductase activity?

Answer 4

Increased cholesterol synthesis.

Cholesterol stones.

Question 5

Pregnancy?

Answer 5

Gallbladder hypomotility. Cholesterol stones.

Question 6

medications (eg, somatostatin)?

Answer 6

Gallbladder hypomotility. Cholesterol stones.

Question 7

prolonged fasting?

Answer 7

Gallbladder hypomotility. Cholesterol stones.

Question 8

parenteral nutrition?

Answer 8

Gallbladder hypomotility. Cholesterol stones.

Question 9

spinal cord injury?

Answer 9

Gallbladder hypomotility. Cholesterol stones.

Question 10

Mechanism of stones in hypomotility?

Answer 10

excessive water resorption from bile and concentration of cholesterol

Question 11

Fibrates (eg, fenofibrate)?

Answer 11

Decreased bile acid synthesis (or recirculation).

Cholesterol stones.

Question 12

Crohn disease?

Answer 12

Decreased bile acid resorption at the ileum –> promotes cholesterol concentration.
Cholesterol stones.

Question 13

Rapid weight loss (eg, gastric bypass)?

Answer 13

Increased calcium or mucin concentration.
Cholesterol stones.

calcium and mucin trap cholesterol crystals and promote stone formation.