UW lentele autoimmune cholangitis Flashcards
what 2 autoimmune cholangitis?
primary biliary cholangitis (PBC)
Primary sclerosing cholangitis (PSC)
which cholangitis in women?
Primary biliary cholangitis (PBC)
which cholangitis in men?
Primary sclerosing cholangitis (PSC)
Assoc with other immune (hashimoto, RA, celiac disease)?
Primary biliary cholangitis (PBC)
Assoc with ulcerative colitis?
Primary sclerosing cholangitis (PSC)
Liver injury pattern in both primary billiary and primary sclerosing?
Cholestatis (inc. alkaline phosphatase)
antibodies: antimitochondrial?
Primary biliary cholangitis (PBC)
antibodies: antinuclear?
But its nonspecific
Primary biliary cholangitis (PBC)
antibodies: p-ANCA?
+/-
nonspecific
Primary sclerosing cholangitis (PSC)
IgM increased in what?
in both
What is florid duct lesion?
granulomatous destruction of small bile ducts
Florid duct lesion in what?
Primary biliary cholangitis (PBC)
Fibrous obliteration of bile ducts with concentric periductal deposition of connective tissue (onion skin-like pattern). In what?
Primary sclerosing cholangitis (PSC)
What ducts affected in primary biliary cholangitis?
small and midsized intrahepatic bile ducts
What ducts affected in primary sclerosing cholangitis?
intrahepatic and extrahepatic bile ducts
Primary symptom of primary biliary cholangitis (PBC)?
pruritus (and bile acids (causing pruritus) due to spillage of bile into the blood; usually the first symptom and may be very severe, especially at night)
what hiperbilirubinemia in primary biliary cholangitis (PBC)?
direct hyperbilirubinemia
Physical manifestation of primary biliary cholangitis (PBC)?
Physical findings typically include jaundice, hepatosplenomegaly. Hypercholesterolemia is also common due to reduced cholesterol excretion –> xanthomatous lesions in the eyelids or in the skin and tendons.
What cells in primary biliary cholangitis (PBC)?
T cells
(T-cell mediated destruction of the small intralobular bile ducts)
what inflammation in primary biliary cholangitis (PBC)?
a patchy dense lymphocytic inflammation of portal tracts with granulomatous destruction of interlobular bile ducts (ie, florid duct lesions) with necrosis and micronodular regeneration of periportal tissues.
granuloma in what disease?
primary biliary cholangitis (PBC)?
Similar findings of primary biliary cholangitis (PBC) found in what condition?
!!Similar findings are seen in hepatic graft versus host disease.
fibrous obliteration of the bile ducts in what disease?
Primary sclerosing cholangitis (PSC)
concentric periductal connective tissue deposition, which resembles an onion skin–like pattern. What disease?
Primary sclerosing cholangitis (PSC)
what bilirubin in Primary sclerosing cholangitis (PSC)?
direct bilirubin (direct hyperbilirubinemia)
ar elevated gamma-glutamyl transferase elevated in sclerosing? nes visi kiti same: incr. phospahtase, mild tranferases, direct hyperbilirubin.
.
instrumental for primary sclerosing cholangitis?
The diagnosis is typically confirmed with cholangiography (eg, MR or endoscopic retrograde cholangiopancreatography) demonstrating multifocal bile duct stricture with segmental dilations.
which can lead to secondary biliary cholangitis?
primary sclerosing cholangitis
which increase risk of cholangiocarcinoma?
primary sclerosing cholangitis
which increase risk of gallbladder cancer?
primary sclerosing cholangitis
which one treatment of ursodiol?
primary biliary cholangitis
