UW lentele autoimmune cholangitis

Question 1

what 2 autoimmune cholangitis?

Answer 1

primary biliary cholangitis (PBC)
Primary sclerosing cholangitis (PSC)

Question 2

which cholangitis in women?

Answer 2

Primary biliary cholangitis (PBC)

Question 3

which cholangitis in men?

Answer 3

Primary sclerosing cholangitis (PSC)

Question 4

Assoc with other immune (hashimoto, RA, celiac disease)?

Answer 4

Primary biliary cholangitis (PBC)

Question 5

Assoc with ulcerative colitis?

Answer 5

Primary sclerosing cholangitis (PSC)

Question 6

Liver injury pattern in both primary billiary and primary sclerosing?

Answer 6

Cholestatis (inc. alkaline phosphatase)

Question 7

antibodies: antimitochondrial?

Answer 7

Primary biliary cholangitis (PBC)

Question 8

antibodies: antinuclear?

Answer 8

But its nonspecific
Primary biliary cholangitis (PBC)

Question 9

antibodies: p-ANCA?

Answer 9

+/-
nonspecific

Primary sclerosing cholangitis (PSC)

Question 10

IgM increased in what?

Answer 10

in both

Question 11

What is florid duct lesion?

Answer 11

granulomatous destruction of small bile ducts

Question 12

Florid duct lesion in what?

Answer 12

Primary biliary cholangitis (PBC)

Question 13

Fibrous obliteration of bile ducts with concentric periductal deposition of connective tissue (onion skin-like pattern). In what?

Answer 13

Primary sclerosing cholangitis (PSC)

Question 14

What ducts affected in primary biliary cholangitis?

Answer 14

small and midsized intrahepatic bile ducts

Question 15

What ducts affected in primary sclerosing cholangitis?

Answer 15

intrahepatic and extrahepatic bile ducts

Question 16

Primary symptom of primary biliary cholangitis (PBC)?

Answer 16

pruritus (and bile acids (causing pruritus) due to spillage of bile into the blood; usually the first symptom and may be very severe, especially at night)

Question 17

what hiperbilirubinemia in primary biliary cholangitis (PBC)?

Answer 17

direct hyperbilirubinemia

Question 18

Physical manifestation of primary biliary cholangitis (PBC)?

Answer 18

Physical findings typically include jaundice, hepatosplenomegaly. Hypercholesterolemia is also common due to reduced cholesterol excretion –> xanthomatous lesions in the eyelids or in the skin and tendons.

Question 19

What cells in primary biliary cholangitis (PBC)?

Answer 19

T cells
(T-cell mediated destruction of the small intralobular bile ducts)

Question 20

what inflammation in primary biliary cholangitis (PBC)?

Answer 20

a patchy dense lymphocytic inflammation of portal tracts with granulomatous destruction of interlobular bile ducts (ie, florid duct lesions) with necrosis and micronodular regeneration of periportal tissues.

Question 21

granuloma in what disease?

Answer 21

primary biliary cholangitis (PBC)?

Question 22

Similar findings of primary biliary cholangitis (PBC) found in what condition?

Answer 22

!!Similar findings are seen in hepatic graft versus host disease.

Question 23

fibrous obliteration of the bile ducts in what disease?

Answer 23

Primary sclerosing cholangitis (PSC)

Question 24

concentric periductal connective tissue deposition, which resembles an onion skin–like pattern. What disease?

Answer 24

Primary sclerosing cholangitis (PSC)

Question 25

what bilirubin in Primary sclerosing cholangitis (PSC)?

Answer 25

direct bilirubin (direct hyperbilirubinemia)

Question 26

ar elevated gamma-glutamyl transferase elevated in sclerosing? nes visi kiti same: incr. phospahtase, mild tranferases, direct hyperbilirubin.

Answer 26

.

Question 27

instrumental for primary sclerosing cholangitis?

Answer 27

The diagnosis is typically confirmed with cholangiography (eg, MR or endoscopic retrograde cholangiopancreatography) demonstrating multifocal bile duct stricture with segmental dilations.

Question 28

which can lead to secondary biliary cholangitis?

Answer 28

primary sclerosing cholangitis

Question 29

which increase risk of cholangiocarcinoma?

Answer 29

primary sclerosing cholangitis

Question 30

which increase risk of gallbladder cancer?

Answer 30

primary sclerosing cholangitis

Question 31

which one treatment of ursodiol?

Answer 31

primary biliary cholangitis