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Uveitis > Uveitis Vol. 3 > Flashcards

Uveitis Vol. 3 Flashcards

1
Q

What medication has been found to diminish the onset of mild CME following surgery?

A

COX inhibitors (egg. by inhibition of prostaglandins)

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2
Q

By what mechanism is lOP thought be lowered in uveitis?

A

Release of PGE1, causing increased uvoscleral outflow as well as decreased aqueous humor production

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3
Q

What are the final products of the 5-lipoxyganasa pathway?

A

Leukotrienes

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4
Q

What pathway is associated with platelet-activating factors?

A

Remodeling pathway

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5
Q

What are chemokines?

A

Cytokines associated with chemotaxis

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6
Q

What cytokine is responsible for migration of Langerhans cells to the central cornea?

A

IL-1

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7
Q

What enzyme is responsible for the formation of hydrogen peroxide?

A

Superoxide dismutase

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8
Q

What is the function of Fenton and Habar-Weiss reaction?

A

Breakdown of hydrogen peroxide into OH- and hydroxyl free radical

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9
Q

What are the 3 class I MHC molecules?

A

HLA -A, -B,-C

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10
Q

What are the 3 class II MHC molecules?

A

HLA -DR, -DP, -DQ

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11
Q

What percentage of patients with acute anterior uveitis express the HLA-B27 haplotype?

A

Approx. 50%

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12
Q

What HLA is associated with acute anterior uveitis?

A

HLA-B27

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13
Q

What HLA is associated with Reiter syndrome?

A

HLA-B27

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14
Q

What HLA is associated with Adamantiades-Behcet syndrome?

A

HLA-B51

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15
Q

What HLA is associated with Birdshot chorioretinitis?

A

HLA-A29

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16
Q

What HLA is associated with sympathetic ophthalmia?

A

HLA-DR4

17
Q

What HLA is associated with VKH syndrome?

A

HLA-DR4

18
Q

What HLA is associated with sarcoidosis?

A

HLA-B8

19
Q

What HLA is associated with multiple sclerosis?

A

HLA-B7

20
Q

What HL.A is associated with ocular histoplasmosis syndrome (OHS)?

A

HLA-B7

21
Q

What HL.A is associated with retinal vasculitis?

A

HLA-B44

22
Q

What is the mechanism of action of corticosteroids?

A

Bind intracellular receptors that translocate into the nucleus and altars DNA transcription into mRNA

23
Q

What is the mechanism of action of alefacept?

A

CD2 receptor inhibitor (e.g. T-cells)

24
Q

What is the mechanism of action of efalizumab?

A

CD11a receptor inhibitor (e.g. T-cells)

25
Q

What is the mechanism of action of anakinra?

A

IL-1 receptor inhibitor (e.g. macrophages)

26
Q

What is the mechanism of action of etanercept?

A

TNF-alpha

27
Q

What is the mechanism of action of infliximab?

A

TNF-alpha

28
Q

What is the mechanism of action of adalimumab?

A

TNF-alpha

29
Q

What is the mechanism of action of rituximab?

A

CD20 inhibitor (e.g. B-cells)

30
Q

What is the mechanism of action of daclizumab?

A

CD25 inhibitor (e.g. activated T-cells)

31
Q

What glycoprotein is found on the surface of all B-calls?

A

CD20

32
Q

What glycoprotein is found on the surface of activated T-cells?

A

CD25

Uveitis (3 decks)

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