Uveitis Vol. 1 Flashcards

1
Q

What are the two main physiologic changes that occur within a tissue in response to inflammation?

A

Cellular recruitment and altered vascular permeability

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2
Q

What is the most abundant type of granulocytes found in the blood?

A

Neutrophils

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3
Q

What cytokine is especially important in the recruitment of eosinophil?

A

IL-5

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4
Q

What type of leukocyte is important mediator of parasitic infections?

A

Eosinophils

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5
Q

What is the blood borne equivalent of tissue-bound mast cells?

A

Basophils

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6
Q

What type of leukocyte does the cornea NOT contain?

A

Mast cells

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7
Q

Where are Kupper cell macrophages located?

A

Liver

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8
Q

What type of cells is associated with Birbeck granules?

A

Langerhans cells

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9
Q

What are the only type m cells that express class II MHC in the conjunctiva and limbus?

A

Langerhans cells

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10
Q

Where do T-cells mature?

A

Thymus

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11
Q

Where do mature, naive lymphocytes reside awaiting exposure to antigens?

A

Lymph nodes

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12
Q

What is the antigen presenting complex of CD4, or helper T-cells?

A

Class II MHC

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13
Q

What is the antigen presenting complex of CD8, or regulatory T-cells?

A

Class I MHC

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14
Q

What is an epitope?

A

Specific region of an antigen that is recognized by the immune system

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15
Q

What is a paratope?

A

Epitope-specific binding site of the Fab portion of the antibody

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16
Q

What is the primary cytokine released by CD4 T-cells in response to activation?

A

IL-2

17
Q

What cytokine released by Th1 calls inhibits Th2 calls?

A

INF-gamma

18
Q

What cytokine released by Th2 calls inhibits Th1 calls?

A

IL-4

19
Q

What type of macrophages are found within the retina?

A

Microglial macrophages

20
Q

What type of immunoglobulins are found in the choroid?

A

lgG and lgA

21
Q

Name 3 characteristics of the cornea that lead to “immune privilege.”

A
  1. Fas ligand 2. Avascularity 3. Lack of central APC
22
Q

What is the most important immunoregulatory system of the conjunctiva?

A

Mucosa-associated lymphoid tissue (MALT)

23
Q

What is the two primary antibodies form by the MALT system?

A

lgA and lgE

24
Q

What is the primary type of helper T-cell of the MALT system?

A

Th2

25
Q

What type of collagen is found in the vitreous?

A

Type II collagen

26
Q

What is the primary characteristic of anterior chamber-associated immune deviation (ACAID)?

A

Robust systemic antibody response but absence of delayed hypersensitivity response

27
Q

What is primary function of Fas ligand?

A

Apoptosis of effector T-cells