Uveitis Vol. 1 Flashcards
What are the two main physiologic changes that occur within a tissue in response to inflammation?
Cellular recruitment and altered vascular permeability
What is the most abundant type of granulocytes found in the blood?
Neutrophils
What cytokine is especially important in the recruitment of eosinophil?
IL-5
What type of leukocyte is important mediator of parasitic infections?
Eosinophils
What is the blood borne equivalent of tissue-bound mast cells?
Basophils
What type of leukocyte does the cornea NOT contain?
Mast cells
Where are Kupper cell macrophages located?
Liver
What type of cells is associated with Birbeck granules?
Langerhans cells
What are the only type m cells that express class II MHC in the conjunctiva and limbus?
Langerhans cells
Where do T-cells mature?
Thymus
Where do mature, naive lymphocytes reside awaiting exposure to antigens?
Lymph nodes
What is the antigen presenting complex of CD4, or helper T-cells?
Class II MHC
What is the antigen presenting complex of CD8, or regulatory T-cells?
Class I MHC
What is an epitope?
Specific region of an antigen that is recognized by the immune system
What is a paratope?
Epitope-specific binding site of the Fab portion of the antibody
What is the primary cytokine released by CD4 T-cells in response to activation?
IL-2
What cytokine released by Th1 calls inhibits Th2 calls?
INF-gamma
What cytokine released by Th2 calls inhibits Th1 calls?
IL-4
What type of macrophages are found within the retina?
Microglial macrophages
What type of immunoglobulins are found in the choroid?
lgG and lgA
Name 3 characteristics of the cornea that lead to “immune privilege.”
- Fas ligand 2. Avascularity 3. Lack of central APC
What is the most important immunoregulatory system of the conjunctiva?
Mucosa-associated lymphoid tissue (MALT)
What is the two primary antibodies form by the MALT system?
lgA and lgE
What is the primary type of helper T-cell of the MALT system?
Th2
What type of collagen is found in the vitreous?
Type II collagen
What is the primary characteristic of anterior chamber-associated immune deviation (ACAID)?
Robust systemic antibody response but absence of delayed hypersensitivity response
What is primary function of Fas ligand?
Apoptosis of effector T-cells
