Uveitis Vol. 2 Flashcards
What type of bacteria is associated with LPS endotoxin?
Gram-negative bacteria
What protein is responsible for most of the inflammatory effects of LPS?
Lipid A
What type of immune response is directed against LPS?
Innate immune response
What is the major cause of shock, fever, and sepsis in gram-negative infections?
LPS
What type of immune response is associated with Type I hypersensivity?
Anaphylactoid
What type of immune response is associated with Type II hypersensivity?
Cytotoxic antibodies
What type of immune response is associated with Type Ill hypersensivity?
Immune complex reactions
What type of immune response is associated with Type IV hypersensivity?
Cell-mediated
What type of immune response is associated with Type V hypersensivity?
Stimulatory
What is function of the Fe portion of antibodies?
Attachment site of effector cells
What are idiotopes?
Anitgenic sites on antibodies that other antibodies can bind to
What are idiotypes?
Antibodies to idiotopes
What is the most common immunoglobin found in the serum?
lgG
What type of antibody crosses the placenta?
IgG
What type of antibody is associated with mast-cell degranulation?
IgE
What is a classic example of antibody complex binding that activates the complement cascade by the membrane attack complex?
Hemolytic anemia of the newborn (eg. due to Rh incompalibilty)
What is the most commonly type of cancer associated with cancer-associated retinopathy?
Small-cell lung cancer
What causes cancer-associated retinopathy?
Antibody mediated cross-reaction between tumor antigens and ocular autoantigens
What is Goldmann-Witmer coefficient used to measure?
Ratio of intraocular localantibody production compared to serum antibody production
What autoantigen is associated with Wegener granulomatosis?
Proteinase-3
What is the function of IFN-gamma and TNF-B?
Activation of macrophages
What type of cells are CD8 cytotoxic T-cells especially good at killing?
Tumor cells and virus infected cells
What is the function of CD951igand (Fasl)?
Cell-programmed death (eg. apoptosis)
What is primary type of immune reaction in sympathetic ophthalmia?
Th1 delayed-hypersensitivity response
What autoantigens are thought to be responsible for sympathetic ophthalmia?
Retinal or uveal antigens
What is the most frequent opportunistic ocular infection in patients with AIDS?
CMV
What type of delayed hypersensitivity response is thought to play a role in allergic conjunctivitis?
Th2-mediated delayed hypersensitivity
Which type of immunity typically activates the classical complement pathway?
Adaptive immunity
Which type of immunity typically activates the alternative complement pathway?
Innate immunity
What are the principal complement-derived immune mediators?
Anaphylatoxins
What complement factor is responsible for opsonization?
C3b
What is the primary role of the Hageman factor-dependent pathway?
Activation of kinins
What enzyme is responsible for the activation of kinins?
Kallikrein
What enzyme converts fibrinogen to fibrin?
Thrombin
What enzyme is responsible for degradation of fibrin?
Plasmin
What is the principle source of serotonin?
Platelets
What two types of cells release histamine?
Mast cells and basophils
What is the primary function of cyclooxygenase?
Conversion of arachidonic acid to PGG2
What type of immune mediators are thought to play a role in cystoid macular edema associated with anterior segment surgery or trauma?
Prostaglandins
