Uveitis Flashcards
Whats used for prophylaxis of pcp?
Bactrim
Whats the fa finding in birdshot?
“Quenching” of the vessels= dye leaving vessels quickly
Rx for jia
Mtx bc have longest safety record w it and dosing is q week
Second line tnfa inhibitor
Name tnf alpha inhibitor
Infliximab
Adilibumab (humira)
Apmppe
Unilat or bilater?
Following viral illness–> Bilat bc its an autoimmune attack of choriocapillaris–> infarcts rpe
Generally good prognosis
Mutton fat KPs aggregates of what type of cell?
macrophages
can pars planitis cause vh and if so how?
yes.
vasculitis–>neo–>vh
Whats a bad compliaction of ra?
Scleromalacia perforans
what type of rd do you get in pars planitis?
rrd or trd from vasculitis and contraction of neo
whats a synonym for C-ANCA?
anti-proteinase 3
what are the main SE of cyclosporine and whats the mechanism?
T cell inhibitor
HTN and renal dz
when psoriatic arthritis develops wo the artritis part, how does it present differently in the eye?
bilateral
older pt
requires oral NSAIDS
If you are on cyclophosphamide, your chance of leukemia is 13x higher if you have what underlying blood disorder?
polycythemia rubra vera
MTX mech and SE
folate analogue
GI upset, hepatotoxicity
Myopentolate mofetil, brand name, mech of axn and SE
cellcept
inhibits Purine synthesis
diarrhea, GI ulceration
what kind of bug is H flu?
gram neg coccus
what bug may be responsible for fuchs heterochromic iridocyclitis?
rubella or CMV
what kind of bug is bartonella?
gram negative rod
besides being bad in MS, what other bad thing can infliximab do?
cause someone to develop lupus and become ana+
whats the best treatment for serpiginous, whats the second option if pt is young?
1) cyclophosphamide is best but cant use it If pt wants to have kids
alternative is prednisone, cyclosporine and azathioprine
whats the term for how the eye responds to a pathogen in a subdued way?
ACAID- anterior chamber associated immune deviation
whats the role of fas ligand in the eye?
fas ligand- the eyes have it!
helps dampen the immune response
whats a sysnonym of reactive arthritis?
reiters
whats circinate balanitis?
penis rash around head of penis associated with reiters
whatst the kveim test?
skin test for sarcoid in which ground up spleen is injected into pt and see if have granulomatous reaction
what type of immune rxn is ocp?
type 2- ab DIRECTLY against surface
heel spurs are a sign of what HLA B27 dz?
reactive arthritis (reiters)
bony destruction of the orbital rim
Langerhans histocytosis
kid w unilateral pig changes, pale nerve. UNILATERAL what could it be
DUSN
what causes loss of vision in congenital rubella?
cataracts and microphthalmos
pt with apmppe comes in with neuropathy- what should you do next?
mra!
apmppee is associated with cerebral vasculitis
what are the clues that an anterior uveitis might be viral?
iris atrophy
stellate KP not confined to vogts triangle
why cant you keep kids on steroids long?
growth retardation
premature closure of epithysis
how does relapsing polychondritis present
scleritis and inflammation of CARTILEDGE
ear tips, nose tip and joint pain
name some sequelae of pars planitis
CME
RRD
VH
Glaucoma
what protein is expressed at the bow region of the lens as it is proliferating?
major intrinsic protein (MIP)
whats the prophylaxis for mai?
rifabutin
whats the prophlaxis for pcp?
bactrim
for uveitic cataract if acrylic is not available, whats the next best choice?
heparin coated pmma
leptospirosis can give false positive of what test?
rpr
pt with lupus has brvo, they are at risk for what?
seizures (other cns stuff)
kid with jia and band k with uncontrolled iop, whats the definitive surg procedure?
tube
how does indomethacin work?
blocks cox
what do corticosteroids block?
phospholipase a2
besides rifabutin and cidofovir which drugs can cause uveitis?
metipranolol
bisphospinates (eg alendronate)
which of the seronehative spondyloarthro[athies is MOST closely ass w HLAB27
ankylosing spondylitis
others:
chrons
psoriatic artiritis
reiters
cysticercosis how to treat?
if actual cysts in retina- surgery
no cysts- thiobendazole
most common SE of cyclophosphomide
hemorrhagic cystitis
kids w sarcoid- what do they get more and wht do they get less?
erythema nodosum MORE
rash- MORE
lung involvemet - LESS
list the steroid drops from strongest to weakest
dex
PF= pred sodium phosphate
FML
Rimexolone
when is a pt w chrons likely hlab27 +, when are they most likely -?
present w scleritis- likely -
present w acute iritis likely + and will get back pain
