Uveal Tract

Question 1

areas of firm attachments between choroid and sclera?

Answer 1

scleral spur, exit points of vortex veins, and at optic nerve

Question 2

name the layers of the iris from anterior to posterior

Answer 2

anterior stromal layer (really just part of the stroma), srtoma, muscular layer, anterior pigmented epithelium, posterior pigmented epithelium

Question 3

from where is the iris dilator muscle derived?

Answer 3

anterior layer of pigmented epithelium

Question 4

What is iris color determined by?

Answer 4

number and size of melanin pigment granules in the anterior stromal melanocyes

Question 5

3 layers of the choroid from anterior to posterior

Answer 5

choriocapillaris, stroma, lamina fusca

Question 6

gene involved in sporadic anirida and Wilms tumor?

Answer 6

PAX6

Question 7

collections of epithelioid histiocytes and lymphoctyes between RPE and Bruch?

Answer 7

Dalen-Fuchs nodules (seen in sympathetic ophthalmia and VKH)

Question 8

diffuse, bilateral, granulomatous inflammation of the uveal tract consisting of epitheliod histiocytes and lymphocytes in patient with prior vitectomy

Answer 8

sympathetic ophthalmia

Question 9

is sympathetic ophthalmia mostly humoral or cell mediated?

Answer 9

cell mediated

Question 10

histologic distinction between sympathetic ophthalmia and VKH?

Answer 10

sympathetic ophthalmia generally spares the choriocapillaris

Question 11

periphlebitis with candle wax dripping appearance in patient with noncaseating granulomatous uveal inflammation

Answer 11

sarcoidosis

Question 12

histology of juvenile xanthogranuloma

Answer 12

skin or uvea involved. collections of lipid-laden histiocytes, Touton giant cells, lymphocytes, and occasional eosinophils. lesions are often vascularized

Question 13

where do the majority of iris melanomas occur?

Answer 13

inferior sectors of iris

Question 14

jet-black peripapillary uveal lesion?

Answer 14

melanocytoma

Question 15

what barrier has been breached in a mushroom shape uveal melanoma?

Answer 15

Bruch membrane

Question 16

tumor that involves the entire circumference of the ciliary body

Answer 16

ring melanoma

Question 17

pigmented choroidal lesion and pigment clumps in angle in patient with high IOP in that eye?

Answer 17

melanomalytic glaucoma

Question 18

2 most important variables associated with survival in uveal melanoma

Answer 18

size of largest tumor dimension in direct contact with sclera, and cell type making up the tumor

Question 19

What is the modified Callender classification? What are the relative prognosis of the different classifications?

Answer 19

classifies cell type of uveal melanomas: spindle (best prognosis), epithelioid (worst), or mixed (intermediate)

Question 20

what chromosomal abnormalities of a uveal melanoma are associated with increased mortality?

Answer 20

monosomy 3 and trisomy 8

Question 21

Which of the following is NOT associated with increased mortality in uveal melanoma?

increased lymphocytes
extrasceral extension
invasion through Bruch membrane
juxtapapillary tumor location

Answer 21

invasion through Bruch membrane

Question 22

mode of metastasis of uveal melanomas?

Answer 22

hematogenous to liver. lymphatic spread is very rare

Question 23

most common intraocular tumor in adults?

Answer 23

metastatic lesion

Question 24

most common primary intraocular malignancy in adults?

Answer 24

uveal melanoma

Question 25

most common uveal met in women? men?

Answer 25

breast. lung.

Question 26

well-defined, yellow-orange peripapillary tumor in young adult female, composed of compact bone?

Answer 26

choroidal osteoma

Question 27

fundus appearance of traumatic choroidal rupture?

Answer 27

semicircular lines circumscribing the optic nerve head in the peripapillary region