UV

Question 1

What is UVI?

Answer 1

Measure of intensity of sun in terms of causing sunburn.

11-12 is extreme - but UK maximum only ~8.

Question 2

What are Langerhan cells?

Answer 2

part of the skin’s immune system. APCs in skin - UV causes them to present antigens in a bad way.

Question 3

What is an action spectrum?

Answer 3

plot of efficacy of a given wavelength FOR a particular biological outcome.
If AS for endpoint is a perfect match for absorption spectrum of CHROMOPHORE –> ideal e.g. in photosynthesis.

Question 4

What have recent studies suggested with regard to sunbed use?

Answer 4

Melanin may act as a sensitizer with UVA to generate CPD.

Question 5

For triplet-triplet energy transfer in the direct effect, what is the final product spectrum reliant on?

Answer 5

Redox potential of excited photosensitizer as affects selectivity of primary attack.

Question 6

How is vitamin D formed into its active component?

Answer 6

In skin forms vitamin 2

2 hydroxylation steps in liver, then kidney yield 1,25(OH)2= the active hormone.

Question 7

What is a potential benefit of UVR?

Answer 7

Reduction in BP.