Parkinson's

Question 1

How is iron involved in PD?

Answer 1

May accelerate ND via OS.
OR increased OS may release iron from its stores.
Expose neonatal mice to iron –> Parkinson-like nd with age.

Question 2

What is Parkin and how is it involved?

Answer 2

An E3 ubiquitin ligase - Norris et al (2015)
Interacts with PINK1 to promote mitochondrial fission.
Under moderate stress stimulates connectivity.
Under high stress triggers mitophagy.

Question 3

What is PINK-1?

Answer 3

A ser/thr kinase - causes Parkin to bind depolarised mt - induces mitophagy
Mt fission (with Parkin)

Question 4

What is DJ-1?

Answer 4

OS sensor
relocates to mt under OS conditions and protective.
Mutants –> increased sensitivity to rotenone, paraquat and H2O2.

Question 5

What did Zandi et al show?

Answer 5

5000 oldies - 3Y intake of antioxidants from foods assessed - reduced prevalence & incidence of Alzheimer’s.

Question 6

What did Zhang show?

Answer 6

High VE intake –> reduced risk of PD (2 large cohorts = nurse’s health study, health professionals follow up).

Question 7

What about Shults et al.?

Answer 7

8- patients with early PD –> 16 mths intervention with CoQ –> slow progressive deterioration of function in PD.