Uterus Flashcards
Endometriosis - What is it?
Chronic inflammatory conditions
Oestrogen dpt
➤ Proliferation of functional endometrial tissue developing outside the uterine cavity (pelvic peritoneum + ovaries)
Endometriosis - S&S
Asymptomatic Chronic pelvic P LBP Dysmenorrhoea Dyspareunia Infertility Menorrhagia Urinary symptoms Cyclical GI
Endometriosis - Risk factors
Unknown ? Smoking ? Nulliparity ? Family Hx ? Age ? Pelvic infection ? White ethnicity
Endometriosis - Ix
Case Hx Increase CA125 Abdo / pelvic exam Pelvic US MRI Laparoscopy
Endometriosis - Staging
➤ Based on location, depth of infiltrates, severity of adhesions
1: minimal
2: mild
3: moderate
4: severe
Endometriosis - Tx
Analgesia - NSAIDs, neuromodulators
Hormone - OCP, progestogen, GnHR agonist & antagonist
Surgery - ablation, excision
Endometriosis - Cx
Endometrioma
Infertility
Ovarian CA
Ovarian cysts / adhesions
Fibroids / Leiomyomas - Age?
Childbeating years
Fibroids / Leiomyomas - Types
Intramural
Submucosal
Subserosal
Pedonculated submucosal
Fibroids / Leiomyomas - S&S
Anaemia Infertility Menorrhagia Dysmenorrhoea LBP Pressure Bowel & bladder pbs Asymptomatic
Fibroids / Leiomyomas - Risk factors
age
ethnicity
family Hx
early puberty
Fibroids / Leiomyomas - What decreases risk?
Progestogen only
Fibroids / Leiomyomas - Influenced by?
Female H
Fibroids / Leiomyomas - Ix
case Hx pelvic exam US MRI hysteroscopy bloods (FBC, Hb)
Fibroids / Leiomyomas - Tx
Decrease oestrogen ➤ be careful with fertility and osteoporosis
➤ Depends on age - Menopause ➤ shrinks
Decrease menorrhagia: levonorgestrel IU, tranexamic acid, OCP, anti-inflammatories, progesterone only
Decrease fibroids: gonadotropin releasing H analogues, ulipristal acetate (synthetic selective progesterone receptor modulator), surgery (hysterectomy, myomectomy)