Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

MD3002 WEEK 10 - K > Uterine Motility > Flashcards

Uterine Motility Flashcards

1
Q

What is the myometrium?

A

The inner layer of the uterus with layer of smooth muscle

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Why are gap junctions important in labour?

A

They are required for depolarisation to spread between all the uterine smooth muscle

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Which gap junction protein is important in the uterus?

A

Connexin 43

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Why is connexin 43 unique?

A

It is hormonally controlled

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is fundal dominance?

A

More contractions in the fundus of the uterus that move downwards during labour
May be caused by more gap junctions present in the fundus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are the sympathetic receptors found in the uterus and what effect do they have?

A

alpha - contraction

beta - relaxation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What determines whether of not the SNS causes relaxation or contraction of the uterus?

A

The ratio of receptor types which is influenced by hormones

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Which pituitary hormones cause contraction of the uterus?

A

ADH

Oxytocin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What effects oxytocin receptor numbers?

A

At term, there is falling progesterone levels with sustained oestrogen levels
Stimulates prostaglandin biosynthesis which results in oxytocin receptor expression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is the effect of oxytocin on the uterus?

A

Stimulates increasingly regular, co-ordinated contractions that travel from the fundus to the cervix (fundal dominance)
Uterus relaxes completely between contractions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are uterine stimulants used for?

A

Abortion
Induction and acceleration of labour
Contract uterus after delivery to control postpartum bleeding

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are uterine relaxants used for?

A

Menstrual cramps
Prevention of preterm labour
Facilitate obstetric manouvers
Counteract uterine hyperstimulation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is oxytocin used for clinically?

A

Given IV to induce labour

IV or IM to control postpartum haemorrhage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is ergometrine used for now a days?

A

Misscarriage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What are the uses of misoprostol in obstetrics?

A

Abortion
Induction of labour
Postpartum haemorrhage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Why is ergometrine not used for women with living foetuses?

A

Powerful uterine contractions will compromise foetus

17
Q

What is syntometrine?

A

Oxytocin and ergometrine combination used for 3rd stage of labour

18
Q

What differing effects do prostaglandins E and F have?

A

E - vasodilator
F - vasoconstrictor
Both act on cervical ripening and induce oxytocin receptors

19
Q

What is the decidua?

A

Pregnant endometrium

20
Q

Give an example of a naturally occurring prostaglandin?

A

Dinoprostone

21
Q

What is carboprost?

A

Synthetic analogue of prostaglandin F2a

22
Q

What is Gemeprost?

A

Synthetic analogue of prostaglandin E1

23
Q

Which type of prostaglandin is dinoprostone equivalent to?

A

E2

24
Q

Which drug is misoprostol used with in abortion to sensitise the uterus?

A

Mifepristone

25
Q

What effect does a rise in cAMP have on smooth muscle?

A

Relaxation

26
Q

How do B-agonists work as uterine relaxants?

A

They bind to receptors causing increase in cAMP which relaxes muscle

27
Q

Give 3 examples of B-agonists

A

Ritodrine
Terbulaine
Salbutamol

28
Q

How do calcium channel blockers cause uterine relaxation?

A

Prevent intracellular calcium increase in smooth muscle which causes contraction

29
Q

How do NSAIDs cause relaxation of uterine smooth muscle?

A

Inhibit prostaglandin biosynthesis

30
Q

Give an example of an NSAID used in obstetrics

A

Indomethacin

31
Q

Name an oxytocin receptor antagonist

A

Atosiban

32
Q

Name a drug used to prevent excess blood loss during mensturation

A

Tanexamic acid

33
Q

Name the different types of drugs that are uterine relaxants

A

Calcium channel blockers
NAIDS
Nitrates
B-agonists

34
Q

Name the different types of drug that are uterine stimulants

A

Ergometrine
Prostaglandins e.g. misoprostol
Oxytocin

35
Q

Give an example of a nitrate uterine relaxant

A

Nitroglycerine patch

36
Q

What may be responsible for dysmenorrhoea?

A

Imbalance between prostaglandin E and F in endometrium

37
Q

Name an antifibrinolytic used in menorrhagia

A

Tranexamic acid

38
Q

Why are NSAIDS used for dysmenorrhoea?

A

Uterine relaxation

Central analgesic effect

MD3002 WEEK 10 - K (9 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions