urticaria and angioedema

Question 1

common cause of acute urticaria

Answer 1

idiopathic, upper respiratory infx, drugs

Question 2

common cause of chronic urticaria

Answer 2

idiopathic, autoimmune disease

Question 3

Hereditary angioedema 1

Answer 3

low C1 inhibitor protein, low C1 inhibitor function, low C4

Question 4

Hereditary angioedema 2

Answer 4

normal C1 inhibitor protein, low C1 inhibitor function, low C4

Question 5

Hereditary angioedema 3

Answer 5

normal C4, defect in FXIII (hageman factor)

Question 6

Acquired angioedema

Answer 6

low C4, low C1q, normal/low C1 inhibitor protein, low C1 inhibitor function

Question 7

what’s the timeline? SJS/TEN, morbiliform vs. urticarial drug eruption, AGEP, DRESS

Answer 7

SJS/TEN, Morbiliform Drug eruption 1-2wks
AGEP 3 days
DRESS 2-6 wks
Urticarial drug eruption - minutes/hours of exposure