HPV

Question 1

which of these is responsible for oral warts, genital warts, RRP, condyloma acuminata?

Answer 1

HPV 6, 11

Question 2

which of these is responsible for flat warts?

Answer 2

HPV 3, 10

Question 3

which of these is responsible for EV-associated SCC?

EV = epidermodysplasia verruciformis

Answer 3

HPV 5, 8

Question 4

which of these is responsible for cervical cancer?

Answer 4

HPV 16, 18, 31, 33, 45

Question 5

which of these is responsible for common warts and palmoplantar warts?

Answer 5

HPV 1,2, 4

Question 6

the virus infects which layer of the epidermis

Answer 6

basal layer

Question 7

which of the early proteins (E1-E7) are oncoproteins?

Answer 7

E6, E7

E6 blocks p53
E7 blocks Rb

Question 8

where are the late proteins (L1-2) found?

Answer 8

at or above the granular layer

Question 9

which of these is responsible for focal epithelial hyperplasia (heck’s disease)?

Answer 9

HPV 13, HPV 32

Heck’s disease - multiple flat wart-like papules on gingival/buccal/labial mucosa

Question 10

what is in the HPV vaccine?

Answer 10

contains L1 major protein w/o the viral DNA material. Thus they can elicit immune response w/o infectious material

Question 11

what is the difference between bowenoid papulosis vs. erythroplasia of queyrat vs. buschke-lowenstein tumor

Answer 11

BP - multiple brown papules/plaques of genitalia that are HSIL or SCCis. progression to invasive SCC is rare

EQ - red smooth plaque on genitalia that are HSIL or SCCis. progression to invasive SCC is rare

BLT - part of a group of verrucous carcinomas that appears like a cauliflower on the external genitalia. caused by HPV 6 and 11