Urticaria

Question 1

common reaction pattern in which pink, itchy
or ‘burning’ swellings (wheals) can occur anywhere on the
body. definition of

Answer 1

urticaria

Question 2

elevated pale compressible
area produced by dermal oedema.

Answer 2

wheal
*do not last longer than 24 hours

Question 3

pathophysiology
type 1 hypersenstivity reaction

Answer 3

Ig-g binds»Ig -E activate mast cell degranulation» histamine release which lead to increased capillary permeability leading to
transient leakage of fluid into the surrounding tissue

Question 4

endogenous causes
*infection during seroconversion

Answer 4

Viral BacterialMycoplasma Intestinal parasites

Connective tissue disorders/cancer lymphoma/coeliac disease

Hypereosinophilic syndrome/hyperthyroidism

Question 5

ordinary vs idiopathic urticaris regarding histamine presence

Answer 5

o:present
I:abscent 70%

Question 6

Angioedema most commonly occurs at junctions
NOTTTTT —————

Answer 6

between skin and mucous membranes
ITCHY

Question 7

COURSE
acute

Answer 7

<6w
will continue until the
allergen is removed, tolerated or metabolize
clear up within a day or two
****even if
the allergen is not identified*

Question 8

course
chronic

Answer 8

angioedema will be clear 5 years
later.
urticarial lesions
50%clear after 6 months

Question 9

DDx

Answer 9

Question 10

DDx

Answer 10

Question 11

Ix
***antihistamines should be stopped for at least 3
days before these
Prick tests are unhelpful for chronic ordinary
urticaria

Answer 11

CBC {eosinphillia :parasitic infection}
Esr{urticarial vasculitis, or a systemic cause}
Fluoroimmunoassays have superseded radio
allergosorbent tests (RAST)

Question 12

Tx
considered 1st line
they are safe in pregnency

Answer 12

anti-histamines {citrizine ,loratadine }
maximum dose 4 times daily

Question 13

Tx in severe cases

Answer 13

ciclosporin ,omalizumab