Urology/Renal Flashcards
What are irritative symptoms of BPH?
increased frequency, urgency, nocturia
What are obstructive sx of BPH?
hesitancy, weak or intermittent stream, incomplete emptying, terminal dribbling
What two classes of drugs may worsen BPH?
Sympathomimetics (Pseudoephedrine) and anticholinergics
uniformly, enlarged, firm, nontender rubbery prostate?
BPH
What is PSA used for?
Risk of symptom progression in BPH
What is a normal PSA level?
< 4 ng/ml
How often should mild symptoms of BPH be monitored?
annually
Best initial txt for rapid relief of BPH?
Alpha blockers (Tamsulo-sin)
What is a sde of alpha blockers?
hypotension
What drug reduces the size of the prostate?
5-alpha reductase inhibitors (Finaste-ride)
Txt for refractory BPH?
TURP
What is a sde of TURP?
sexual dysfunction, urinary incontience
What is a sde of Finasteride?
sexual dysfunction, decreased libido, breast enlargement/tenderness
MC cause of erectile dysfunction?
vascular
What test is used to evaluate sleep erections?
nocturnal penile tumescence
1st line txt for erectile dysfunction?
phosphodiesterase- 5 inhibitors (Sildenfil)
What is the mechanism of phosphodiestrase 5 inhibitors?
increases GMP and potentiates nitric oxide mediated penile smooth muscle relaxation
C/I for Viagra?
pts who use nitrates and cardiovascular dx
What is a adv rxn of Viagra?
headache, flushing, rhinitis, visual disturbances, hearing loss
What lie is seen in testicular torsion?
horizontal lie
What lie is seen epididymitis?
vertical lie
What is Prehn sign?
pain relief w/ scrotal elevation
What is cremasteric reflex?
elevation of testicle after stroking the inner thigh
What two signs are negative in testicular torsion?
Phren and cremasteric reflex
What is the definitive dx for testicular torsion?
emergency surgical exploration
What dx tool can be used in testicular torsion?
testicular doppler ultrasound
Txt for testicular torsion?
urgent detorsion & orchiopexy
What time frame should a testicular torsion be repaired?
< 6hrs
If surgery is not available what procedure can be done in testicular torsion?
manual detorsion
MC cause of prostatitis in age >35y?
E. coli
MC cause of prostatitis in age < 35yr
Chlamydia & Gonorrhea
MC cause of chronic prostatitis?
E. coli
What sx are seen in acute prostatitis?
fever, chills, perineal pain, frequency, urgency, dysuria
exquisitely tender, normal or hot, boggy prostate
Acute prostatitis
non-tender, boggy prostate
chronic prostatits
What sx are seen in chronic prostatitis?
recurrent UTIs or intermittent dysfunction
What should be avoided in acute prostatitis?
prostatic massage
Txt for acute prostatitis in >35yr?
Fluoroquinolones or Bactrim
Txt for acute prostatitis in <35yr?
Ceftriaxone + Doxycycline (Azithromycin)
Txt for chronic prostatitis?
Fluoroquinolones or Bactrim. Alpha blockers
Txt for refractory chronic prostatitis?
TURP
MC nephrotic syndrome in children?
Minimal change disease
MC primary nephrotic disease in caucasian males?
membranous nephropathy
MC secondary cause of nephrotic disease in adults?
DM
Symptoms seen in nephrotic syndrome?
generalized edema, frothy urine, DVT
What is the biggest RISK with nephrotic syndrome?
DVT
What is the initial test for dx nephrotic syndrome?
UA
Fatty casts are seen in what disease?
nephrotic syndrome
What is the gold standard test for dx nephrotic syndrome?
24 urine protein > 3.5g/day
What is the definitive dx for nephrotic syndrome?
renal biopsy
1st Txt for nephrotic syndrome?
glucocorticoids
What is the txt for steroid resistant nephrotic syndrome?
Cyclosporine
What is used to reduce protein loss in nephrotic syndrome?
ACE or ARBS
What causes DVT in nephrotic syndrome?
loss of protein C, S, and antithrombin III
What 4 things are seen in nephrotic syndrome?
proteinuria, hypoalbuminemia, hyperlipidemia, edema
What 4 things are seen in nephritic syndrome?
hypertension, hematuria (RBC casts), azotemia, proteinuria
What is the MC cause of acute glomerulonephritis?
IgA Nephropathy (Berger’s dx)
Seen after URI or GI infection, due to overproduction of IgA?
Berger’s disease
Most common seen after group A strep infection?
post-infectious glomerulonephritis
2-14y boy w/ facial edema after srep w/ scanty, cola colored dark urine
post-infectious glomerulonephritis
Pt presents with acute glomerulonephritis + hemoptysis?
Goodpasture’s disease
Hallmark for acute glomerulonephritis?
hematuria. (cola or tea colored urine)
What is common on PE forglomerulonephritis?
hypertension
RBC casts?
acute glomerulonephritis
Txt for IgA nephropathy?
ACE inhibitors, +/- Corticosteriods
Txt for post-streptococcal AGN?
SUPPORTIVE
What is the MC cause of AIN?
Drug hypersensitivity