Urology/Renal Flashcards

1
Q

What is cryptorchidism?

A

the failure of testes to descend (one or both)

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2
Q

What are the characteristics of cryptorchidism?

A
  • an undescended testicle is generally rare in full-time babies but common in baby boys born prematurely (30%)
  • if not repaired risks infertility and malignancy
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3
Q

How is cryptorchidism dx?

A

-ultrasound may be helpful identifying undescended testicles in abdominal space

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4
Q

What is the tx of cryptorchidism?

A

treat with surgery (orchiopexy) by age 1

-the current recommendation is to correct as soon as possible after 4 months of age

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5
Q

What is cystitis?

A

bacterial UTIs are frequent cause of pediatric morbidity

  • cystitis is when the infection is limited to the bladder
  • girls have a 10-fold risk over boys
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6
Q

What is the most common bacterial pathogen in cases of UTI in children?

A

escherichia coli

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7
Q

What is the most significant risk factor for UTI in children?

A

the prescience of a urinary tract abnormality that causes stasis, obstruction of reflux

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8
Q

What are the symptoms of cystitis in older children?

A

similar to those in adults and include fever, frequency, urgency, dysuria, incontinence, abdominal pain, and hematuria

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9
Q

What are the symptoms in newborns and infants with UTI?

A

nonspecific signs, including fever hypothermia, jaundice, poor feeding, irritability, vomiting, failure to thrive, and sepsis
-strong, foul-smelling or cloudy urine may be noted

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10
Q

What is the dx of cystitis?

A

screening urinalysis indicates pyuria (>5 WBCs/HPF) in most children with UTI some children can have sterile pyuria with UTI

  • urine culture is the gold standard for diagnosis, susceptibility testing should be performed
  • in toilet-trained older children a midstream, a clean-catch method is usually satisfactory
  • in infants and younger children, bladder catheterization or suprapubic collection is necessary in most cases to avoid contaminated samples
  • bagged urine specimens are helpful only if negative
  • asymptomatic bacteriuria is detected in 0.5-1% of children screened with urine culture
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11
Q

Who needs to get a renal and bladder ultrasonography (RBUS)?

A
  • vesicoureteral reflux (VUR) is detected in 30-50% of children presenting with a UTI at <1 y/o
  • the American academy of pediatrics (AAP) recommends RBUS for all infants and children 2 to 24 months following their first febrile UTI
  • children of any age with recurrent febrile UTIs
  • children of any age with a UTI who have a family history of renal or urologic disease, poor growth, or hypertension
  • children who do not respond as expected to appropriate antimicrobial therapy
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12
Q

What is the tx of cystitis?

A
  • cephalosporin x 14 days are the first-line oral agent in the treatment of UTI in children without genitourinary abnormalities
  • first-generation cephalosporin (Keflex 50-100 mg/kg BID) for low risk of renal involvement
  • second-generation (cefuroxime) or third-gen (cefixime, cefdinir, ceftibuten) for those with a high likelihood of renal involvement
  • amoxicillin and ampicillin are not routinely recommended for empiric therapy because of the high rate of resistance of E. coli
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13
Q

What is enuresis?

A

involuntary loss of urine in child older than 5 years

-it may be nocturnal or daytime, or both and primary or secondary

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14
Q

When is successful bladder control usually achieved?

A

between the ages of 24 and 36 months, although many developmentally normal children take significantly longer

  • clinically significant: occurs > two times per week for > three consecutive months or affects day to day life
  • age: > 5 years old
  • not caused by other substances
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15
Q

What is primary enuretics?

A

patients who have never successfully maintained a dry period
-primary nocturnal enuresis is thought to be due to delayed maturational control or inadequate levels of ADH secretions during sleep

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16
Q

What is secondary enuretics?

A

dry for several months before regular wetting occurs

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17
Q

How is enuresis dx?

A

enuresis should first be tested with a urinalysis and urine culture to rule out infection
-then a thorough history and physical with fluid intake, stool, and voiding diary should be compiled in order to investigate abnormal patterns seen in conditions like constipation or diabetes insidious

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18
Q

What is the tx of enuresis?

A

patients younger than 5 years of age do not require investigation or treatment, patients and family should be informed that bed-wetting is normal at their age and will likely resolve with time

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19
Q

What is the behavioral modification for the tx of enuresis?

A

nighttime audio alarm that sounds as soon as the child starts to urinate, eventually conditioning controlled bladder emptying before enuresis

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20
Q

What are the medications that can be used to tx enuresis?

A

desmopressin acetate (DDAVP) acts to concentrate the urine, if given in the evening, less urine is produced overnight, decreasing the likelihood of wetting

  • with all therapies, the cure rate is 15% per year after the age of 5
  • children who remain enuretic past age 8 have a 10% risk of never resolving their symptoms
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21
Q

What is glomerulonephritis?

A

implies inflammation of the glomerular basement membrane
-antigen-antibody complexes are formed or deposited in the sub epithelial or subendothelial areas, immune mediators follow, resulting in inflammatory injury

22
Q

What is the hallmark of the glomerulonephritis?

A

hematuria, overt or microscopic

23
Q

What is acute glomerulonephritides?

A

post infectious - group A strep (skin or throat) - 10-14 days after infection - diagnosed with ASO titers and low serum complement - treatment is supportive + antibiotics

  • group A streptococcal skin infection 3-6 weeks prior
  • throat infection 1-3 weeks prior
  • serum C3 and C4 can be decreased
  • kidney biopsy not usually necessary
24
Q

What is rapidly progressive glomerulonephritis?

A

crescent formation on biopsy due to fibrin and plasma protein deposition

25
Q

What is good pasture’s syndrome?

A

(+) anti-GBM antibodies, dx linear IgG deposits, treat with high dose steroids, plasmapheresis + cyclophosphamide

26
Q

What is vasculitis?

A

lack of immune deposits (+) ANCA antibodies

  • microscopic polyangitis (+) P-ANCA
  • granulomatosis with polyangiitis (Wegener’s) (+) C-ANCA
27
Q

What are the chronic glomerulonephritides disease?

A
  • IgA Nephropathy (Berger disease)
  • Alport’s Syndrome
  • Membranoproliferative glomerulonephritis
28
Q

What is IgA nephropathy (Berger disease)?

A
  • often affects young males within days (24-48 hours) after URI or GI injection - caused by IgA immune complexes which are first line of defense in respiratory and GI secretions so infections cause an overproduction which then damages the kidneys
  • slowly progresses to renal failure in 25% of cases
  • renal biopsy alone makes the diagnosis demonstrating mesangial despots of IgA in the glomeruli
29
Q

What is Alpert’s syndrome?

A
  • presents as isolated persistent painless hematuria
  • a genetic condition that occurs in children resulting in renal failure and hearing loss
  • ophthalmologic exam reveals anterior lenticonus - anterior part of the lens has a conical shape
  • DX: C3 and C4 levels
30
Q

What is membrnoproliferative glomerulonephritis?

A

due to SLE, viral hepattisi

31
Q

What are the manifestations of glomerulonephritis?

A

proteinuria, HTN, azotemia, oliguria (<400 ml urine/day), hematuria (RBC casts) hallmark, edema is not as much as nephrotic syndrome

32
Q

How is glomerulonephritis dx?

A
  • urinalysis: proteinuria <3.5 grams per day (a 24-hour urine), hematuria, RBC casts
  • biopsy: hyper cellular, immune complex deposition
33
Q

What is the tx of glomerulonephritis?

A

positive streptococcal cultures are treated with appropriate antibiotic therapy

  • steroids and other immunosuppressive drugs may be used to control the inflammatory response
  • dietary management: salt and fluid restriction
  • hypertension when present can be severe, requiring vasodilators, diuretics, and fluid restriction
  • dialysis should be performed if symptomatic azotemia
  • IgA nephropathy - glucocorticoids
  • rapidly progressive glomerulonephritis - immunosuppressive therapy
  • use of medications to control hyperkalemia, pulmonary edema, peripheral edema, acidosis, and hypertension
  • may require renal transplant - most syndromes recur in the transplanted kidney
34
Q

What is a hydrocele?

A

a collection of fluid around the testicle or along the spermatic cord leading to a non-tender fluid-filled (cystic) mass

35
Q

What are the characteristics of a hydrocele?

A
  • this occurs when lymphatic drainage from the scrotum is impaired, leading to swelling and enlargement
  • hydrocele is common in newborns and typically disappears without treatment during the first year of life
  • however, treatment is indicated if the mass becomes large and uncomfortable
36
Q

How is a hydrocele dx?

A

scrotal ultrasound can be used in the diagnosis of both hydrocele and varicocele
-the hydrocele can be visualized with transillumination Tumor or varicocele which both do not transilluminate

37
Q

What is the tx of hydrocele?

A

treatment usually involves watchful waiting

  • in rare circumstances, surgery is needed
  • most hydroceles will resolve within the first 12 months of life without treatment and do not need to be reassessed unless present after 1-year
  • if elective repair is indicated treatment consists of needle aspiration or surgery
  • patients will require scrotal support after treatment, and they should be monitored for bleeding or infection at the site after intervention
38
Q

What is hypospadias?

A

(more common than epispadias)

when the urethra opens onto the bottom (undersea) of the penile shaft

39
Q

What defines the hypospadias?

A

the position of the urethral meatus

  • granular - head of the penis (lease severe)
  • midshaft - middle of the penis
  • penalscrotal - where the penis and sctorum come together (most severe)
40
Q

How is the dx of hypospadias?

A

usually made during the newborn exam but imaging studies (excretory urogram) can aid in the diagnosis

41
Q

What is the tx of hypospadias?

A

surgical repair, usually performed before 1-2 years of age

-do not circumcise - foreskin may be used to reconstruct the urethra

42
Q

What is paraphimosis?

A

an inability to return the foreskin to normal position

  • entrapment of the foreskin behind glans
  • causes a tourniquet effect and is a medical emergency
  • more acute than phimosis
43
Q

How is paraphimosis treated?

A

treat by applying firm circumferential compression to the glans with the hand - may relieve edema sufficiently to allow the foreskin to be restored to its normal position

  • if this technique is ineffective, a dorsal silt using local anesthetic relieves the condition temporarily
  • circumcision is then done when edema has resolved
44
Q

What is phimosis?

A

is an inability to retract the foreskin

  • usually resolves by age five
  • unable to retract the foreskin
  • more chronic than paraphimosis
45
Q

What is the tx of phimosis?

A

treat with betamethasone topically, if no improvement circumcision

46
Q

What is a testicular torsion?

A

caused by a twisting of the testicle around the cord supplying blood to the scrotum

47
Q

What are the signs and symptoms of testicular torsion?

A
  • asymmetric high riding testicle “bell clapper deformity” negative preens sign (lifting of testicle will not relieve pain)
  • teenage males
  • sudden, severe pain and swelling in the testicle are symptoms
  • associated with nausea and vomiting
  • very tender to palpation
  • cremaster reflext absent
  • blue dot sign: tender nodule 2 to 3 mm in diameter on the upper pol of the testicle
48
Q

How is a testicular torsion dx?

A

diagnose with ultrasound and radionuclide study (gold standard)

49
Q

What is the tx of testicular torsion?

A

surgical emergency: repair both tests within 4-6 hours

-a longer wait may affect fertility

50
Q

What is a vesicoureteral reflux?

A

a condition in which urine flows retrograde or backward, from the bladder into the ureters/kidneys
-in young female patients, any history that points to recurrent infection, especially cystitis or pyelonephritis, should trigger an evaluation for vesicoureteral reflux (VUR)

51
Q

How is vesicoureteral reflux dx?

A

diagnose by using VCUG and monitor by using serial ultrasonography and VCUGs

52
Q

What is the tx of vesicoureteral reflux?

A

mild to moderate VUR often resolves spontaneously, but the more serious disease may require surgical intervention
-children with newly diagnosed VUR are given prophylactic antibiotics depending on their clinical course