Urology - Passmedicine Flashcards
What are causes of scrotal swellings?
Inguinal hernia Testicular tumours Acute epididymo-orchtis Epididymal cysts Hydrocele Testicular torsion Variocele
What does an inguinal hernia present like?
Inguinoscrotal swelling (can’t get above it)
Cough impulse may be present
May be reducible
How do testicular tumours tend to present?
Discrete testicular nodules
What investigations are required in suspected testicular tumour?
USS scrotum
Serum AFP
bHCG
How does acute epididymo-orchitis tend to present?
Hx dysuria, urethral discharge
Swelling may be tender + eased by elevating testis
What causes most cases of epididymo-orchitis?
Chlamydia
At what age are epididymal cysts more common?
> 40 years
How do epididymal cysts tend to present?
Painless cyst above and behind the testis (may contain clear/opalescent fluid)
Usually possible to get above the lump
How does a hydrocele present?
Non-painful, soft, fluctuant swelling
Can get above it
Contains clear fluid + will transilluminate
What may a hydrocele be a presenting feature of?
Testicular cancer in young men
How does testicular torsion present?
Severe, sudden onset testicular pain Usually in a young male O/e testis is tender and pain not eased by elevation (Prehn's sign), swollen, tender testis is retracted upward, skin may be reddened Pain may be referred to lower abdomen NV
What are risk factors for testicular torsion?
Abnormal testicular lie
How is testicular torsion managed?
Urgent surgery
Contralateral testis also fixed
What is a variocele?
Varicosities of the pampiniform plexus
Where do varioceles typically occur and why?
On the left (as the testicular vein drains into the renal vein)
What can a variocele be a presenting feature of?
Renal cell carcinoma
Do varioceles affect fertility?
They can if they are bilateral
How is testicular malignancy treated?
Orchidectomy via inguinal approach - allows high ligation of testicular vessels + avoids exposure of another lymphatic field to the tumour
How can torted testicles be fixed?
Sutures or placement of the testis in a Dartos pouch
How are varioceles managed?
Usually conservatively
If concerns about testicular function/infertility then surgery/radiological management may be considered
How can epididymal cysts be excised?
Via scrotal approach
How are hydroceles managed?
In children (pathology is due to patient processus vaginalis + so) inguinal approach to ligate processus is used
In adults a scrotal approach is preferred + the hydrocele sac is excised/plicated (Lords or Jabouley procedure)
95% of testicular cancers are what?
Germ cell tumours
How are germ cell tumours divided?
Seminoma
Non-seminomatous germ cell tumours
What are the kinds of Non-seminomatous germ cell tumours?
Teratoma
Yolk sac tumour
Choriocarcinoma
Mixed germ cell tumour
What is the commonest subtype of testicular tumour?
Seminoma
What is the average age of diagnosis with a seminoma?
40
How is survival with a seminoma?
Good
What do the tumour markers tend to show in a seminoma?
HCG and AFP often normal
Lactate dehydrogenase raised in 10-20%
What do you see on the histology of a seminoma?
Sheet like lobular patterns of cells with substantial fibrous component
Fibrous septa contains lymphocytic inclusions + granulomas
What is the average age of diagnosis of non-seminoma germ cell tumours?
20-30
What is the prognosis of non-seminoma germ cell tumours?
Much worse
Apart from excision what additional treatments may be required to manage non-seminoma germ cell tumours?
Retroperitoneal LN dissection after chemo
What do you tend to see in the tumour markers of someone with a non-seminoma germ cell tumour?
AFP raised 70%
HCG raised 40%
What is the histology of non-seminoma germ cell tumours?
Heterogenous texture with occasional ectopic tissue, e.g. hair
What are RFs for testicular cancer?
Cryptorchidism Infertility FH Klinefelter's syndrome Mumps orchitis
What is the most common presenting symptom for testicular cancer?
Painless lump
other features: hydrocele, gynaecomastia
What is the first line imaging for suspected testicular cancer?
US
+ tumour markers
What imaging is used to stage testicular cancer?
CT chest/abdo/pelvis
How is testicular cancer managed?
Orchidectomy (inguinal approach)
Chemo/radio depending on stage
Abdominal lesions >1cm following chemo may req. retroperitoneal lymph node dissection
What is acute epididymitis?
Acute inflammation of the epididymis
What drug can cause epididymitis?
Amiodarone
How can you differentiate epididymitis from torsion?
In epididymitis, the tenderness is usually confined to the epididymis
Torsion usually affects the entire testis
What is testicular torsion?
Twist of spermatic cord leading to testicular ischaemia and necrosis
When is it most common to get a testicular torsion?
Aged between 10 and 30
What is the pain of testicular torsion like?
Usually severe + of sudden onset
What reflex is lost in testicular torsion?
Cremasteric
How is testicular torsion treated?
Surgical exploration
In younger men, why should hydrocele be investigated with testicular US?
To rule out tumour
What diagnosis must you exclude when someone presents with epididymo-orchitis?
Testicular torsion!!
What factors may suggest torsion over epididymo-orchitis?
Age <20
Severe pain
Sudden onset
How does epididymo-orchitis tend to present?
Unilateral testicular pain + swelling
Urethral discharge may be present, but urethritis is often asymptomatic
How should you treat epididymo-orchitis if the organism is unknown?
Ceftriaxone 500mg IM single dose + doxycycline 100mg PO BD 10-14d
In sexually active men <35y the commonest cause of epididymo-orchitis is chlamydia. what is the most common cause in men >35y?
Usually enteric organisms (e.g. E. coli, E. faecalis) that cause UTIs
What is the analgesic of choice for renal colic?
IM diclofenac
Is circumcision for religious/cultural reasons available on the NHS?
No
What are the medical benefits of circumcision?
Reduces risk of penile cancer, UTIs, STIs (incl. HIV)
What are medical indications for circumcision?
Phimosis
Recurrent balanitis
BXO
Paraphimosis
What is it important to check for before circumcising a boy and why?
Exclude hypospadias as foreskin may be used in surgical repair
What type of anaesthetic is used to perform a circumcision?
LA or GA
What is priapism?
A persistent penile erection (typically defined as lasting >4 hours and is not associated with sexual stimulation0
What are the two types of priapism?
Ischaemic
Non-ischaemic
What causes ischaemic priapism?
Impaired vasorelaxation and therefore reduced vasocular outflow –> congestion and trapping of de-oxygenated blood in the corpus cavernosa
What are causes of non-ischaemic priapism?
High arterial inflow, typically due to fistula formation (congenital/traumatic)
At what ages is it most common to get priapism?
5-10y or 20-50y
What are causes of priapism?
Idiopathic Sickle cell dx/haemoglobinopathies Erectile dysfunction mediation Drugs - anti-hypertensives, anticoagulations, antidepressants, cocaine, cannabis, ectasy Trauma
How does priapism tend to present?
Persistent erection
Pain localised to the penis
Hx of haemoglobinopathy/medication
Hx trauma to genital/perineal region
What features in the history would be more suggestive of non-ischaemic priapism compared to ischaemic priapism?
A non-pain erection or an erection that is not fully rigid
What is the best investigation to differentiate between non-ischaemic priapism and ischaemic priapism?
Cavernosal blood gas analysis
Doppler/duplex can be used as alternative
What other investigations may be done for priapism?
FBC, toxicology to assess for cause
How is priapism diagnosed?
Clinically
Investigations to help decide if ischaemic or not
Why does ischaemic priapism require urgent treatment?
Delayed treatment can lead to permanent tissue damage and long-term erectile dysfunction
How is ischaemic priapism managed?
Aspiration of blood from cavernosa (often combined with injection of saline flush to help clear viscous blood that has pooled)
If this fails - intracavernosal injection of vasoconstrictive agent, e.g. phenylephrine used and repeated at 5 min intervals
If this fails - consider surgery
How is non-ischaemic priapism managed?
Normally observation first line (not medical emergency)
What post-void volumes are considered physiological in patients <65 years old?
<50ml
What post-void volumes are considered physiological in patients >65 years old?
<100ml
What is prostate specific antigen?
A serine protease enzyme produced by normal and malignant prostate epithelial cells
What are the age adjusted upper limits for PSA?
a. 50-59
b. 60-69
c >70
a. 3
b. 4
c. 5
What things may raised PSA levels (not to do with prostate cancer)?
BPH Prostatitis and UTI Ejaculation Vigorous exercise Urinary retention Instrumentation of the urinary tract
How long after an episode of prostatitis or UTI should you wait to have your PSA checked?
At least 1 month after treatment
How long before getting your PSA checked should you avoid ejaculation?
48 hours
How long before getting your PSA checked should you avoid vigorous exercise?
48 hours
What % of men with prostate cancer will have a normal PSA?
20%
Which drugs are sometimes used to aid the spontaneous passage of a renal stone?
CCBs
Define erectile dysfunction
Persistent inability to attain and maintain an erection sufficient to permit satisfactory sexual performance
How are the causes of ED split?
Organic cause
Psychogenic cause
Mixed
What factors favour an organic cause of ED?
Gradual onset of symptoms
Lack of tumescence
Normal libido
What factors favour a pyschogenic cause of ED?
Sudden onset of symptoms Decreased libido Good quality spontaneous/self-stimulated erections Major life events Problems/changes in relationship Prev. psychological prolems Hx of premature ejaculation
What are RFs for ED?
CV disease RFs - obesity, DM, dyslipidaemia, metabolic syndrome, HTN, smoking
Alcohol use
What drugs can cause ED?
SSRIs, beta blockers
What investigations should be done for someone with ED?
10 year CV risk
Free testosterone measured between 9-11am (if low/borderline repeat with FSH and LH and prolactin, if abnormal - refer to endocrine)
What is involved in the treatment of ED?
1st line: PDE-5 inhibitors (e.g. sildenafil (Viagra) - given for all aetiologies
2nd line - vaccuum erection devices
If a young man has always had difficulty achieving an erection what additional management should be have?
Referral to urology
People with ED doing what activity for >3 hours a week should be advised to stop?
Cycling