UROLOGY - Bladder + Prostate Flashcards
What type of cancer are 90% of bladder cancers?
TCC;s
RF bladder cancer/TCC (4)
Smoking
Aromatic amines
Chronic cystitis
Pelvic irradiation
PS TCC/bladder cancer (4)
Painless haematuria +/- clots
Recurrent UTI/’cystitis’
Voiding Sx
Haematuria –> anaemia
Mx TCC in situ/T1
TURBT @ cystoscopy _ intravesical chemotherapy
Mx TCC T2-3
Radical cystectomy + pre op chemo
Ix TCC
Urine MCS
Cystoscopy + biopsy = GOLD STANDARD
CT/MRI - assess spread
Mx TCC T4
Palliative
Mx of intraperitoneal bladder rupture
Laparotomy + suturing of bladder
Mx of extraperitoneal bladder rupture
Prolonged urethral/suprapubic catheter
Bladder outlet obstruction - luminal causes
Bladder tumour
Bladder outlet obstruction - mural causes (3)
Urethral stricture
Congenital abnormalities
Neuropathic bladder
Bladder outlet obstruction - extra mural causes (2)
BPH/carcinoma
Phimosis/paraphimosis
CF Bladder outlet obstruction
Suprapubic pain Hesitancy + diminished force of stream Terminal dribbling Overflow incontinence Signs infection - stasis urine
Signs - bladder outlet obstruction (3)
Palpable full bladder
Loin tenderness
Enlarged prostate PR
Ix Bladder outlet obstruction (4)
Bloods - FBC/U+E
Urine dip/MCS
USS
CT/MRI
What is BPH
Benign proliferation of glandular layers of the prostate –> enlargement of inner transitional zone
What % of >70s have BPH
70%
Sx BPH (8)
Freq (1st noticed as nocturia) Urgency Hesitancy Poor/int stream Post void dribbling Strangury Retention w/ overflow incontinence/acute retention Occasionally - haematuria
Ix BPH (8)
PR IPPS Freq/vol chart Bloods incl FBC/U+E/PSA Urinalysis Uroflowmetry Bladder USS Transrectal USS + biopsy
Norm PSA value
<4
Apart from BPH/Prostate cancer, what other conditions cause PSA to rise (5)
Inflammation Infection Trauma Ejaculation Ageing
Acute Mx BPH
Attempt urethral catheter drainage
Lifestyle mods BPH (4)
Avoid alcohol
Relax when voiding
void twice in a row
Bladder retraining
Medical Tx BPH
Alpha blockers 0 tamulosin, doxasosin
5a reductase inhibitors - finasteride
SE alpha blockers (4)
Dizzy
Drowsy
HoTN
Depression
SE 5a reductase inhibitors (2)
Impotence
Decreased libido
Surgical Mx BPH (2)
TURP - retrograde ejaculation almost universal after
HoLEP - endoscopic
What % of >80s have prostate cancer
80%
What type of cancers are the majority of prostate cancers?
Adenocarcinomas
Spread - prostate cancer (34)
Local
Lymphatic
Haematogenous
Bone to BONE
Risk factors prostate cancer (2)
FHx
Raised testosterone levels
PS Prostate cancer
Asymp often
Filling/voiding Sx
W loss/bone pain if mets
O/E Prostate cancer
hard craggy prostate
Ix prostate cancer (4)
PR
PSA
Transrectal USS/biopsy
Bone XR/scan
What 2 scores can be used in Prostate cancer
Gleason grade
D’Amico risk stratification
How does Gleason grade work
2 areas of tissue are graded/5
Indicative of prognosis
Gleason grade 6
Low risk/good prognosis
Gleason grade 8>
High risk/ bad prognosis
What is D’Amico risk stratfication
Combines Gleason w/ clinical stage + PSA
==> more accurate prognosis
Mx prostate cancer - T1/2
Active surviellance
Radiotherapy
Radical prostatectomy
Mx prostate cancer - T3/4
Radiotherapy or surgery
Mx prostate cancer - mets
GnRH agonists - goserelin/busereline
+ antiandrogen (cyrpoterone acetate)
Prevents early rise testosterone
Mx - urethral trauma - partial
Prolonged catheter
Mx = urethral trauma - complete tear
Suprapubic catheter + repair
What is a urethral stricture
Scar of the urethral epithleium, which commonly extends into the underlying corpus spongiosum
What part of the urethra is most commonly damaged in a urethral stricture
Bulbar urethra
Causes urethral stricture (4)
Blunt perineal trauma (#/saddle injury)
Iatrogenic (catheter)
Gonococcal/non-gonococcal urethritis
BXO
PS urethral stricture (4)
Initial frequency/dysuria
Hesitancy/straining
Urinary retention
Splayed stream
O/E urethral stricture
Firm areas consistent w/ scarring
Ix urethral stricture (3)
Uroflowmetry
Retrograde urethrogram
Urethroscopy
Mx urethral stricture
Optical urethrotomy
Mx recurrent urethral stricture
Urethroplasty