BREAST Flashcards
When is a fibroadenoma?
Common benign breast lump
Who gets fibroadenoma’s
Young F (<30)
Features of fibroadenoma
Not fixed to Chx wall Smooth/rubbery Solid Painless Well-circumscribed Painless
When may a fibroadenoma want to be removed for cosmetic purposes?
If the woman has small breasts
b/c can cause a large deviation
Why do fibroadenosis + cysts occur
Menstrual cycle
What age group gets fibroadenosis + cysts
30-50 y/o
What may cysts + fibrous nodules feel like o/e
Bubble wrwap
If cysts are multiple, what are they related to?
Homones
Which quadrant of the breast has the highest % of carcinoma?
Upper outer quadrant
What is the most common cancer in females?
Breast cancer
What are the 2 main cell types in breast cance r
Ductal
Lobar
Can you usually palpate breast carcinoma in situ
No
PS breast carcinoma (5)
Breast mass Pain Nipple changes Dimpling breast tissue Local oedema
Non specific Sx breast carcinoma
W loss
Loss appetitie
Fatigue
Features of lump - breast carcinoma (4)
Hard
Spiky
Not well circumscribed
Fixed to chest wall
How does breast carcinoma spread
Via direct extension
Lymphatics + bloods
Pleura + peritoneum
Symptom + related mets: SOB
Lung mets + pleural effusion
Symptom + related mets:
Headache/vision change/seizure
Brain mets
Symptom + related mets: abdo pain
Liver mets
Symptom + related mets: abdo distention
Ascites
Symptom + related mets: bone pain, weakness, numbness
SC compression
RF breast carcinoma (10)
= ALL TO DO W/ HIGH CIRCULATING OESTROGEN Female Late menopause/early menarche OCP HRT FHx Age Nulliparity < time breast feeding 'Western lifestyle'
What % breast cancers are familial
5-10%
What assessment are most breast lumps referred for?
Triple assessment
What is ‘triple assessment’
Combo of 3 tests
Clinical exam, radiology + pathology
How are biopsies of the breast performed
Either Freehand if not palpable
Stereotactic if cant be seen on mammogram
What is the sensitivity of triple assessment?
99%
Why are mammograms not useful on young patients
Because their breast tissue is very dense
So all comes up as white hence = difficult to see anything
USS - black circle w/ well defined margin =
cyst
USS - grey/black circle w/ well defined margin =
Something capsulated :)
USS - grey/black circle w/ ill-defined margin =
Cancer
Nipple discharge - what does clear mean
Physiological
Nipple discharge - what does milky mean (2)
Pregnancy
Hyperprolactinaemia
Nipple discharge - what does green discharge mean
Duct ectasia around menopause
Fibroadenotic cyst
Nipple discharge - what does single blood stained duct discharge mean
V worrying
What to do if pt has Single blood stained duct discharge
Microducetomy
What is most suspicious, single or multiduct discharge
Single duct
What is periductal mastitis
Infection of ducts beneath the nipple
Who is more likely to suffer from periductal mastitis (2)
Smokers
Those w/ nipple piercings
Mx periductal mastitis
Flucloxacillin
What is the most common cause of breast pain?
MSK
Mx cyclical breast pain
Tamoxifen/danzol
Mx all breast pain
Evening primrose oil
Breast TNM: T1
<2cm
Breast TNM: T2
2-5cm
Breast TNM: T3
> 5cm
Breast TNM: T4
Fixed to chest wall
Or Peau d’orange
Breast TNM: N0
No nodes
Breast TNM: N1
Mobile ipsilateral nodes
Breast TNM: N2
Fixed nodes
Breast TNM: M0
No distant mets
Breast TNM: M1
Distant mets
Further Ix if you suspect a patient of having mets
Liver USS
CXR
Bone scan
What is another name for breast conserving surgery?
WLE - Wide local excision
What does WLE involve
Excising tumour w/ 1cm margin
Making sure microscopically margins are clear
When is a mastectomy used? (4)
Multifocal disease
High tumour:breast
Disease recurrence
Pt choice
What are the 2 types of axillary surgery
Sentinel node biopsy
Axillary node clearance
What is sentinel node biopsy
Remove the 1st LN into which tumour drains
This involves using a blue dye
Node is removed + sent for histological analysis
What is Axillary node clearance
Remove all nodes in axilla
What treatment is most surgery combined with?
Radiotherapy
When to consider using chemo for Tx breast cancer
If nodal disease
High grade tumours
Chemotherapeutic agents used in breast cancer (3)
Anthracyclines
Cyclophosphamides
methotrexate
What additional Tx is given to pt who are either HER2 or ER +ve - pre-menopausal
5 y of tamoixfen
What additional Tx is given to pt who are either HER2 or ER +ve - post menopausal
Aromastase inhibitors e.g. letrazole, aromisin
What additional Tx is given to pt who are HER2 +ve
Herceptin
If there are mets, what Tx is recommended
Surgery for Sx relief
Radiotherapy for palliation
What is the NPI
Nottingham porgnostic index which assesses survival and risk relapse
How is the NPI calculated?
Size (cm x 0.2) + grade (1-3) + nodes (0 = 1point, 1-3 = 2 points, >3 = 3 points)
10 y survival rate (after surgery) NPI <2.4
95%
10 y survival rate (after surgery) NPI 2.4-3.4
85%
10 y survival rate (after surgery) NPI 3.4-4.4
70%
10 y survival rate (after surgery) NPI 4.4-5.4
50%
10 y survival rate (after surgery) NPI >5.4
20%
Age at which breast cancer screening starts
47-50
How often are women screen for breast cancer?
Every 3 years
When does breast screening end
After 73 y/o
If a women is older than 73 can she been screened?
No but she can request a scan
Which type of breast cancer has the poorest prognosis?
HER2+