Urology Flashcards
weight of a healthy prostate?
20grams
where is the prostate located anatomically?
Inferior to the bladder neck
anterior to the rectum
what is the arterial supply of the prostate?
internal iliac artery -> inferior vesical artery -> prostatic arteries -> urethral and capsular arteries
venous drainage of the prostate?
prostatic plexus near dorsal vein -> internal iliac vein-> IVC
lymphatic drainage of the prostate?
obturator and internal iliac channels
which part of the prostate is the origin for most prostate cancers?
peripheral zone of prostate
which part of the prostate is responsible for BPH?
transitional zone of prostate
where increased number of cells in BPH
what is the physiological function of the prostate?
to make seminal fluid to aid sperm passage
prevents retrograde ejaculation by acting like a sphincter
what are the properties of seminal fluid that aid it in assisting passage of sperm?
alkaline
contains fructose
prostaglandins
clotting factors
LUTS symptoms refer to symptoms caused by pathology from which part of the urethral tract?
from the bladder down
what are the 2 categories of LUTS symptoms?
storage
voiding
what are the storage symptoms of LUTS?
Frequency
Urgency
Nocturia
What are the voiding symptoms of LUTS?
Weak stream
Intermittency
Straining
Emptying incompleteness
BPH red flags/other sx:
bone pain weight loss haematuria infection incontinence pain sexual dysfunction
why is family history important when suspected BPH?
BRCA gene linked
3 times when you wouldn’t do a DRE:
no consent
,<16yo
neutropenic sepsis
what is the difference between hyperplasia and hypertrophic?
hyperplasia - increased number of cells - increased size of tissue
hypertrophic - increased size of cells
definition of BPH:
histological diagnosis reflecting:
- hyperplasia/hypertrophia
- bladder outlet obstruction
- LUTS
aetiology of BPH:
age-related hormone changes
hyperplasia of transitional zone cells
vascular/inflammatory event
metabolic syndrome
pathophysiology of BPH:
mechanical fault or smooth muscle pathology -> detrusor overactivity (bladder smooth muscle)
which category of LUTS is commoner?
voiding
what are the complications of BPH?
persistent UTIs
incontinence
urinary retention
what investigations would you do for BPH:
bloods - glucose, HbA1c, PSA
urinalysis
?USS
special tests
what special tests would you do to ix BPH?
flow studies frequency-volume chart IPSS score - sx, QOL score -> mild/mod/sev cystoscopy Urodynamics
management options for BPH:
conservative
medical
surgical
what are the conservative mx for BPH:
fluid intake manipulation caffeine reduction and other trigger reduction bladder training tx constipation meds rec (diuretics)
what are the 3 main medication classes for BPH?
- alpha 1 blockers (Tamsulosin)
- 5a-reductase inhibitors (Finasteride)
- Anticholinergics
what are some sfx of tamsulosin (2):
orthostatic hypotension
retrograde ejaculation
what is the benefit of using tamsulosin to tx BPH?
works fast
what are some sfx of Finasteride?
mood
sex dysfunction
gynaecomastia
tx for hairloss!
mechanism of action of finasteride?
prevents the conversion of testosterone to dihydrotestosterone (DHT) so less serum DHT
less proliferation of prostate
less mechanical pinching
what are the benefits of using finasteride to treat BPH?
halves PSA
30% reduction if prostate size
how long does finasteride take to work fully
6/12
name some surgical options for BPH?
TURP Urolift Steam treatment Holep laser / green light laser open prostatectomy prostatic artery embolisation
What is TUR syndrome and what causes it?
absorption of glycine in too high a concentration triad: -hyponatraemia -fluid overload -glycine toxicity
what are the symptoms of TUR syndrome?
CNS - blindness, confusion, coning
Heart - arrhythmias, SOB, pain
Abdo - n/v
what type of cancer are most prostate cancers?
adenocarcinoma
which races are at higher risk for prostate cancer?
black>white>asian
what are the risk factors for prostate cancer?
congen- fhx, age, race
acquired - metabolic syndrome
signs and sx of prostate cancer?
asx non-spec ca sx bone/back pain LUTS haematuria incidental finding from TURP for BPH abnormal DRE
how does prostate feel on DRE in BPH?
smooth
how does prostate feel on DRE in prostate cancer?
hard, craggy
what is PSA?
prostate specific antigen
protein made by prostate epithelial cells
what are normal PSA levels for different ages?
50-60 - <3ng/ml blood
60-70 - <4ng/ml blood
70-80 - <5ng/ml blood
80+ - no limit
if PSA > 50, what does this usually indicate?
usually prostate cancer
is PSA > 100, what does this usually indicate?
metastatic prostate cancer
is PSA used to screen for prostate cancer?
no
how many PSA’s are needed to confirm suspicion and prompt further tests?
2 separate high PSA scores
what imaging is done to ix prostate cancer?
- MP-MRI - look for high grade prostate cancer, measure size of prostate
- CT abdo/pelvis
NM bone scan
special tests done to ix prostate cancer? (and methods of doing this)
prostate biopsy - transrectal v transperineal**
what are the benefits of doing a transperineal prostate biopsy?
fewer risks and increased accuracy
what does staging of prostate cancer tell us?
how far ca spread from origin
what staging system is used for prostate cancer?
TNM
what does grading tell us about prostate cancer?
how well differentiated cells are
what score indicates the grading?
Gleason score
what 3 features make up the risk stratification of prostate cancer?
Gleason score
initial PSA
T score
general management of prostate cancer?
mdt
specialist nurse
lower RFs
ca support groups
what are the 4 treatment options for prostate cancer?
watchful wait
active surveillance
surgery
medicine
what is the difference between watchful wait and active surveillance?
watchful wait - defer further tx til metastasis or PSA increase - palliative
active surveillance - chance to cure active disease - watched more regularly like a hawk
what are the surgical options for prostate cancer and what are the indication for doing ?
- RALP (robot assisted Laproscopic Prostatectomy) - da vinci machine
radical (T3+) - RT +/- brachytherapy. oncologists
during a RALP, what anastamosis is formed?
bladder neck - urethra
side effects of RALP?
infertility erectile dysfunction incontinence bleeding infection catheter conversion to open leaking anastamosis