Opthalmology Flashcards
define glaucoma?
refers to a number of disorders where there is a progressive optic neuropathy and raised intraocular pressure is typically a key factor
which condition is characterised by a normal angle between the iris and cornea. It is divided into primary and secondary forms?
open angle glaucoma
commonest form of glaucoma?
primary open angle glaucoma
which condition is characterised by a closing or narrowing of the angle between the iris and cornea. Again may be split into primary and secondary forms?
angle-closure glaucoma
pathology closed angle glaucoma??
The closure of the anterior chamber angle (cornea-iris. due to lens being pushed against the iris) results in reduced drainage of the aqueous humour and rising IOP rapidly - cupping
pressure builds up particularly in posterior chamber
threshold above which IOPs are said to be raised?
21mmHg
what are the boundaries of the anterior chamber of the eye?
cornea - iris
what are the boundaries of the posterior chamber of the eye?
iris - lens `
boundaries of the vitreous chamber?
lens-back of the eye
anterior chamber filled with??
aqueous humor
posterior chamber filled with ??
vitreous humor
what does the cilliary epithelium do in the eye?
produces the aqueous humor
provides structural support
what is the normal pathway of the aqueous humor in the eye?
produced by the cilliary epithelium into post chamber flows to anterior chamber through trabecular meshwork canal of schemm aqueous veins (part of the episcleral venous system)
pathology open angle glaucoma?
angle between cornea and iris ‘open’ - slow clogging of trabecular meshwork over time
-> gradual increase in pressure on Optic nerve - cupping
-> outer rim atrophy - decrease in peripheral vision
THEN central vision loss as pressure increases
symptoms of closed angle glaucoma?
eye pain, redness, blurred vision, headaches, nausea, visual halos
what does tonometry assess?
introccular pressure
what will optic nerve imaging and direct observation show in closed angle glaucoma?
‘cupping’
medications for glaucoma?
to lower pressure by decreasing aqueous humor production - 1. BBs,
carbonic anhydrase inhibitors (dorzolamide)
to increase outflow of humor - prostaglandin analogues also 1.
to do both: alpha adrenergic agonists
treatments (non-pharm) for glaucoma:
trabeculoplasty - OA
laser iridotomy - CA
causes of ectropion:
muscle weakness
bell’s palsy - facial paralysis
trauma/previous surgery
eyelid growths
watery eyes, excessive dryness of eyes - gritty and sandy
easy irritated eyes - burning sensation and redness
photophobia:
ectropion
ectropion mx:
surgical definitive
what causes stye?
saureus
can be described in questions as an eyelid abscess
differentiate between stye and chalazion?
styes are typically tender to palpate
what respiratory abnormality may be the cause of papilloedema?
hypercapnia
commonest cause of unilateral red eye?
conjunctivitis
Contact lens wearers who present with a red painful eye mx?
always refer to opthalm to assess and rule out microbial keratitis
define keratitis?
inflammation of the cornea
aims of angle-closure glaucoma tx?
reduce aqueous humor secretion
induce pupillary constriction (to make pupil smaller and create more space for outflow)
74-year-old woman presents to the emergency department with a sudden loss of vision in her left eye, which occurred three hours ago and lasted for approximately 3 minutes. She describes the episode as a ‘black-out’ of her vision in that eye, with no associated pain or nausea, and denies any other symptoms. PMH: vasculopath - dx?
Amaurosis fugax
what is amaurosis fugax?
painless, transient monocular blindness together with the description of a ‘black curtain coming down’ is characteristic of amaurosis fugax
You perform a cover test to gather further information. Which one of the following findings would be consistent with a right esotropia?
on covering the left eye the right eye moves laterally to take up fixation
man presents with a ‘droopy eyelid’ on the right side. You also notice that his right pupil appears smaller than the left: indicates??
horner’s syndrome
59-year-old man complains of dry, sore eyes for the past six months. There has been no change in his vision and he doesn’t wear contact lens. The only past history of note is hypothyroidism. dx?
blepharitis
can be associated with seborrheoic dematitis
what is blepharitis?
inflammation of the eyelid margins
what can lead to fungal infections, which in turn can cause corneal ulcers?
steroid eye drops
Blunt ocular trauma with associated hyphema indicates?
high risk of glaucoma as raised ICP
man who presents to eye casualty with sudden onset loss of vision in his left eye. He is not experiencing any pain and has a past medical history of diet-controlled type 2 diabetes mellitus and hypertension. Slit-lamp examination reveals red blood cells in the anterior vitreous. dx?
vitreous haemorrhage
especially consider in diabetics
what disease is characterised by drusen - yellow round spots in Bruch’s membrane?
dry age related macular degeneration
what disease is characterised by choroidal neovascularisation.?
wet age related macular degeneration
sudden painless loss of vision, severe retinal haemorrhages on fundoscopy - dx?
CRVO
3 risk factors for CRVO?
increasing age
glaucoma
polycythaemia
pale retina on fundoscopy indicates ?
CRAO
features include afferent pupillary defect, ‘cherry red’ spot on a pale retina
CRAO
name some risk factors for vitreous haemorrhage:
Diabetes Trauma Anticoagulants Coagulation disorders Severe short sightedness
55-year-old lady presenting with red-tinged vision along with dark spots. These are typical features of ?
vitreous haemorrhage
Peripheral curtain over vision + spider webs + flashing lights in vision think??
retinal detachment
unilateral black shadow at the top of her right vision. She has also been experiencing flashing lights in spindly shapes, this came on suddenly a few hours ago. dx?
retinal detachment
28-year-old male with controlled ulcerative colitis (UC) presents to the clinic with an acute painful right eye. There is decreased vision and redness around the right eye. This is the first time presenting with these symptoms. smaller pupil in right eye.
Slit light examination shows inflammatory cells and an aqueous flare in the anterior chamber. dx?
anterior uveitis
also hypopyon (pus in anterior chamber)
tx anterior uveitis?
steroid eye drops with mydriatic eye drops
what is a suitable screening test for childhood squints?
corneal light reflection test
sudden vision loss. painless loss of red reflex cannot see retina poorly controlled DM dx?
vitreous haemorrhage
red hue to vision
6-yom to ED: swelling around his right eye. This has been present or the past 2 days and during this time he has been feverish and lethargic. He denies any loss of vision or trauma to the eye.
38.2ºC. right-sided proptosis, and all eye movements are reduced and painful in the affected eye. Fundoscopy is normal, visual acuity is 6/6 in the left and 6/12 in the right eye.
What is the most likely diagnosis?
orbital cellulitis
ceftriaxone
differentiating periorbital/orbital cellulitis?
reduced visual acuity, proptosis, ophthalmoplegia/pain with eye movements are NOT consistent with periorbital (preseptal) cellulitis
CT with contrast
Absence of painful movements, diplopia and visual impairment indicates periorbital
common causes of orbital cellulitis?
strep, staph, hib
severe pain: may be ocular or headache
decreased visual acuity
symptoms worse with mydriasis (e.g. watching TV in a dark room)
hard, red-eye (corneal injection)
haloes around lights at night
semi-dilated non-reacting pupil (fixed, dilated)
corneal oedema results in dull or hazy cornea
systemic upset may be seen, such as nausea and vomiting and even abdominal pain
dx?
acute angle-closure glaucoma
NICE guidelines say that any patient with life/sight-threatening causes of red eye should be…..?
referred to opthalm for same day assessment
2 methods for measuring IOP?
non-contact tonometry
goldmann’s applanation
when to start tx open angle glaucoma and first line tx?
started when IOP >24mmHg
1st line: PG analogue eye drops: latanoprost.
SE: eyelash growth, eyelid pigmentation, iris pigmentation.
2nd line: BB (timolol; reduce production aq humour). Carbonic anhydrase inhibitors (dorzolamide).
Surgery: trabeculotomy: create a new channel under sclera.
which medications can cause acute angle closure glaucoma?
adrenergic (adrenaline), anticholinergics (oxybutynin), TCA
if delay in ambulance for closed angle glaucoma pt, what mx can help in interim?
Lie patient on their back without a pillow
**Give pilocarpine eye drops (2% for blue, 4% for brown eyes) – acts on muscarinic receptos in the sphincter muscles and causes constriction of the pupil (headache, blurred vision).
+ ciliary muscle contraction – opens up the pathyway for the flow of aqeuus humour
**Give acetazolamide 500 mg orally(reduce production aqeuos humour)
Given analgesia and an antiemetic if required
which chemical stimulates the development of new vessels in wet age related macular degeneration?
VEG-F
Vascular endothelial growth factor
Gradual worseningcentral visual field loss
-Reducedvisual acuity
Crooked or wavy appearance to straight lines
refers to ???
ARMD
what is a Scotoma?
central patch of vision loss
how is AMD diagnosed?
slit-lamp exam by opthalmologist
optical coherence tomography
fluorescein angiography
dry AMD mx?
lifestyle factors to slow progression
smoking, BP, vitamins
wet AMD mx?
anti-VEGF drugs
ranibizumab,bevacizumabandpegaptanib
monthly injections into vitreous chamber
start <3/12 to be effective
fundoscopy changes: cotton wool spots, neurovascularisation, blot haemorrhages, hard exudates, microaneurysms - dx?
diabetic retinopathy
how is diabetic retinopathy classified?
proliferative or non-proliferative depending on whether new vessels have developed
cx of diabetic retinopathy:
Retinal detachment
Vitreous haemorrhage(bleeding in to the vitreous humour)
Rebeosis iridis(new blood vessel formation in the iris)
Optic neuropathy
Cataracts
mx diabetic retinopathy:
Laser photocoagulation
Anti-VEGFmedications -ranibizumab/bevacizumab
Vitreoretinal surgery(keyhole) may be required in severe disease
fundoscopy changes:
cotton wool spots, retinal haemorrhages, papilloedema, arteriovenous nipping, hard exudates, silver wiring - dx?
hypertensive retinopathy
mx: hypertensive retinopathy:
Management is focused on controlling the blood pressure and other risk factors such as smoking and blood lipid levels.
what is the role of the lens in physiology?
to focus light on the retina
which part of the eye anatomy contracts and relaxes to focus the lens?
cilliary body
how are congenital cataracts screened for?
red light reflex - new born assessment
“Starbursts” can appear around lights, particularly at night time
asymmetrical, generalised slow reduction in vision, blurriness
colour changes -> brown/yellows
dx?
cataracts
ix for cataracts?
loss of red light reflex
lens can appear grey or white when testing red reflex
tx cataracts:
Cataract surgery involves drilling and breaking the lens into pieces, removing the pieces and then implanting anartificial lensinto the eye. This is usually done as a day case under local anaesthetic. It usually gives good results.
regardless of acuity!
rare but serious cx of cataracts surgery:
Endophthalmitis - inflammationof the inner contents of the eye, usually caused by infection. It can be treated withintravitrealantibiotics
can cause loss of vision
mx blepharitis?
hot compress
eye hygeine
lubricating eye drops - hypromellose, polyvinyl alc(1), carbomer