Urology Flashcards
Urinary Tract Obstruction Causes
Luminal
Stones
Blood clots
Sloughed papilla
Mural
Congenital / acquired stricture
Tumour: renal, ureteric, bladder
Neuromuscular dysfunction
Extramural
Prostatic enlargement
Abdo / pelvic mass / tumour
Retroperitoneal fibrosis
UT Obstruction Presentation
Acute
Upper Urinary Tract
Loin pain → groin
Lower Urinary Tract
Bladder outflow obstruction precedes severe
suprapubic pain w distended palpable bladder
Chronic
Upper Urinary Tract
Flank pain
Renal failure (may be polyuric)
Lower Urinary Tract
Frequency, hesitancy, poor stream, terminal
dribbling, overflow incontinence
Distended, palpable bladder ± large prostate
PR
UT obstruction Ix
Bloods: FBC, U+E
Urine: dip, MC+S
Imaging US: hydronephrosis or hydroureter Anterograde / retrograde ureterograms Allow therapeutic drainage Radionucleotide imaging: renal function CT / MRI
UT obstruction Mx
Upper Urinary Tract
Nephrostomy
Ureteric stent
Lower Urinary Tract
Urethral or suprapubic catheter
May be a large post-obstructive diuresis
Complications of Ureteric Stents
Common Infection Haematuria Trigonal irritation Encrustation
Rare
Obstruction
Ureteric rupture
Stent migration
Urethral Stricture
Trauma
Instrumentation
Pelvic #s
Infection (gonorrhoea)
Chemotherapy
Balanitis xerotica obliterans
Urethral Stricture Presentation + examination
Voiding difficulty Hesitancy Strangury Poor stream Terminal dribbling Pis en deux
Examination
PR: exclude prostatic cause
Palpate urethra through penis
Examine meatus
Urethral Stricture Ix + Mx
Urodynamics
↓ peak flow rate
↑ micturition time
Urethroscopy and cystoscopy
Retrograde urethrogram
Mx
Internal urethrotomy
Dilatation
Stent
Obstructive Uropathy
Acute retention on a chronic background may go
unnoticed for days due to lack of pain.
Se Cr may be up to 1500uM
Renal function should return to normal over days
Some background impairment may remain.
Obstructive Uropathy Complications
Hyperkalaemia
Metabolic acidosis
Post-obstructive diuresis
Kidneys produce a lot of urine in the acute phase
after relief of obstruction.
Must keep up c¯ losses to avoid dehydration.
Na and HCO3 losing nephropathy
Diuresis may → loss of Na and HCO3
May require replacement 1.26% NaHCO3
Infection
Urinary Retention Causes
Obstructive (Mechanical) BPH Urethral stricture Clots, stones Constipation (Dynamic): ↑ smooth muscle tone (α-adrenergic) Post-operative pain Drugs
Neurological Interruption of sensory or motor innervation Pelvic surgery MS DM Spinal injury / compression
Myogenic
Over-distension of the bladder
Post-anaesthesia
High EtOH intake
Acute Urinary Retention (AUR)
Clinical Features
Ix
Clinical Features Suprapubic tenderness Palpable bladder Dull to percussion Can’t get beneath it Large prostate on PR Check anal tone and sacral sensation <1L drained on catheterisation
Ix
Blood: FBC, U+E, PSA (prior to PR)
Urine: dip, MC+S
Imaging
US: bladder volume, hydronephrosis
Pelvic XR
Acute Urinary Retention
Mx
Conservative Analgesia Privacy Walking Running water or hot bath
Catheterise
Use correct catheter: e.g. 3-way if clots
± STAT gent cover
Hrly UO + replace: post-obstruction diuresis
Tamsulosin: ↓ risk of recatheterisation after retention
TWOC - Trial Without Catheter after 24-72h
May d/c and f/up in OPD
More likely to be successful if predisposing factor
and lower residual volume (<1L)
TURP (trans-urethral-resection of prostate)
- failed TWOC
- Impaired renal function
- Elective
Chronic Urinary Retention
Classification
High Pressure
High detrusor pressure @ end of micturition
Typically bladder outflow obstruction
→ bilateral hydronephrosis and ↓ renal function
Low Pressure
Low detrusor pressure @ end of micturition
Large volume retention w very compliant bladder
Kidney able to excrete urine
No hydronephrosis :. normal renal function
Chronic Urinary Retention
Presentation
Insidious as bladder capacity ↑↑ (>1.5L)
Typically painless
Overflow incontinence / nocturnal enuresis
Acute on chronic retention
Lower abdo mass
UTI
Renal failure
Chronic Urinary Retention
Mx
High-Pressure
Catheterise if Renal impairment Pain Infection Hrly UO + replace: post-obstruction diuresis Consider TURP before TWOC
Low-Pressure
Avoid catheterisation if possible - Risk infection
Early TURP
Often do poorly due to poor detrusor function
Need CISC or permanent catheter
Suprapubic Catheterisation
adv disadv C/I
Advantages ↓ UTIs ↓ stricture formation TWOC w/o catheter removal Pt. preference: ↑ comfort Maintain sexual function
Disadvantages
More complex: need skills
Serious complications can occur
CI
Known or suspected bladder carcinoma
Undiagnosed haematuria
Previous lower abdominal surgery → adhesion of small bowel to abdo wall
Clean Intermittent Self-Catheterisation
Alternative to indwelling catheter in AUR and CUR
Also useful in pts. who fail to void after TURP
False Haematuria causes
Beetroot
Rifampicin
Porphyria
PV bleed
True Haematuria causes
General
HSP
Bleeding diathesis
Renal Infarct Trauma: inc. stones Infection Neoplasm GN Polycystic kidneys
Ureter
Stone
Tumour
Bladder Infection Stones Tumour Exercise
Prostate
BPH
Prostatitis
Tumour
Urethra Infection Stones Trauma Tumour
Haematuria Clinical Features
Timing?
Beginning of stream: urethral
Throughout stream: renal / systemic, bladder
End of stream: bladder stone, schisto
Painful or painless?
Obstructive symptoms?
Systemic symptoms: wt. loss, appetite
Haematuria Ix
Bloods: FBC, U+E, clotting
Urine: dip, MC+S, cytology
Imaging Renal US IVU Flexible cystoscopy + biopsy CT/MRI Renal angio
Peri-Aortitis
Idiopathic retroperitoneal fibrosis
Inflammatory AAAs
Perianeurysmal RPF
RPF 2ndary to malignancy: e.g. lymphoma
Idiopathic Retroperitoneal Fibrosis
Autoimmine vasculitis
Fibrinoid necrosis of vasa vasorum
Affects aorta + small/medium sized retroperitoneal vessels
Ureters are embedded in dense, fibrous tissue > bilateral obstruction
Peri-aortitis ass/ Presentations
Ass/
Drugs: β-B, bromocriptine, methysergide, methyldopa
AI disease: thyroiditis, SLE, ANCA+ vasculitis
Smoking
Asbestos
Presentation Middle–aged male Vague loin, back or abdo pain ↑ BP Chronic urinary tract obstruction
Peri-aortitis Ix Rx
Ix
Blood: ↑U and Cr, ↑ESR/CRP, ↓Hb
US: bilateral hydronephrosis + medial ureteric deviation
CT/MRI: peri-aortic mass
Biopsy: exclude Ca
Rx
Relieve obstruction: retrograde stent placement
Ureterolysis: dissection of ureters from retroperitoneal
tissue.
± immunosuppression
Urolithiasis
↑ concentration of urinary solute
↓ urine volume
Urinary stasis
Common anatomical sites Pelviureteric junction Crossing the iliac vessels at the pelvic brim Under the vas or uterine artery Vesicoureteric junction
Stone types (Urolithiasis)
Calcium oxalate: 75%
↑ risk in Crohn’s
Triple phosphate (struvite): 15%
Ca Mg NH4 – phosphate
May form staghorn calculi
Assoc. c¯ proteus infection
Urate: 5% (radiolucent)
Double if confirmed gout
Cystine: 1% (faint)
Assoc. c¯ Fanconi Syn
Urolithiasis Associated factors
Dehydration
Hypercalcaemia: primary HPT, immobilisation
↑ oxalate excretion: tea, strawberries
UTIs
Hyperuricaemia: e.g. gout
Urinary tract abnormalities: e.g. bladder diverticulae
Drugs: frusemide, thiazides
Urolithiasis Presentation
Ureteric colic (severe loin to groin pain, n/v, pt cannot lie still)
Bladder or Urethral Obstruction
Bladder irritability: frequency, dysuria, haematuria
Strangury: painful urinary tenesmus
Suprapubic pain radiating → tip of penis or in labia
Pain and haematuria worse at the end of micturition
Other features UTI Haematuria Sterile pyuria Anuria
Urolithiasis Ix
Urine
Dip: haematuria
MC+S
Blood
FBC, U+E, Ca, PO4, urate
Imaging
KUB XR
90% of stones radio-opaque
Urate stones are radiolucent, cysteine stones are faint
USS: hydronephrosis
Spiral non-contrast CT-KUB
99% of stones visible
Gold standard
IVU
600x radiation dose of KUB
IV contrast injected and control, immediate and serial
films taken until contrast @ level of obstruction
>Abnormal findings
Failure of flow to the bladder
Standing column of contrast
Clubbing of the calyces: back pressure
Delayed, dense nephrogram: no flow from kidney
C/I - Contrast allergy, Severe asthma, Metformin, Pregnancy
Functional Urinary System Scans
DMSA: dimercaptosuccinic acid
DTPA: diethylenetriamene penta-acetic acid
MAG-3
Urolithiasis Prevention
Drink plenty
Treat UTIs rapidly
↓ oxalate intake: chocolate, tea, strawberries
Urolithiasis Mx
<5mm and lower 1/3 - conservative
Medical - stone 5-10mm
- Nifedipine or tamsulosin
+/- prednisolone
Active stone >10mm, persistent, renal insufficiency, infection
Extracorporeal shockwave lithotripsy
Ureteronoscopy + dormier basket removal
Percutaneous
Lap or open surgery rare
Febrile renal obstruction
surgical emergency
percutaneous nephrostomy or ureteric stent
IV abx - cefuroxime 1.5g IV TDS