Urology (3) (infection) Flashcards
lower urinary tract infection
involve infection in the bladder, causing cystitis (inflammation of the bladder). They can spread up to the kidneys and cause pyelonephritis
RF for uti
- Women (urethra is shorter)
- Sexual activity- bacteria spread around the perineum from the anus)
- Incontinence
- Poor hygiene
- Urinary catheters
causes of bacterial UTI
Causes
-
Bacteria- E.coli most common
- Klebsiella pneumonia
- Pseudomonas aeruginosa
- Primary sources faeces
presentation of lower urinary tract infection
- Dysuria (pain, stinging or burning when passing urine)
- Suprapubic pain or discomfort
- Frequency
- Urgency
- Incontinence
- Haematuria
- Cloudy or foul smelling urine
- Confusion is commonly the only symptom in older and frail patients
investigations for UTI
- dipstick
- MSU
Dipstick and UTI
- Nitrites (gram neg bacteria break down nitrates, a normal waste product in urines, into nitrites)
- Leukocytes
-
RBC
- Presence of leukocytes +RBC indicates likelihood of UTI
- If only leukocytes present do not treat
MSU
mid stream urine
- Microscopy, culture and sensitivity testing
- Asymptomatic bacteriuria- positive urine cultures without symptoms of UTI (common in elderly)
uncomplicated UTI
Uncomplicated UTIs are most common in young, sexually active women.
occurs in patients who have a normal, unobstructed genitourinary tract, who have no history of recent instrumentation, and whose symptoms are confined to the lower urinary tract.
complicated UTI
A complicated urinary tract infection (UTI) is a term to describe a UTI that doesn’t respond to traditional treatments. This may be due to underlying medical conditions or other risk factors, such as age and anatomical differences
- Pregnant patients
- Patients with recurrent UTIs
- Atypical symptoms
- When symptoms do not improve with antibiotics
- Men with UTI
management of uncomplicated UTI
- Trimethoprim for 3 days
- Nitrofurantoin for 3 days
side effects of trimethoprim and nitrofurantoin
- Side effects same for both:
- Itching
- D and V
- Stomach upset
- Loss of appetite
management of asymptomatic bacteriuria
- Offer antibiotics to pregnant women
- Usually doesn’t need to be treated in nonpregnant
management of UTI in pregnant patients
- Avoid nitrofurantoin in third trimester- risk of neonatal haemolysis
- Avoid trimethoprim in first trimester- works as a folate antagonist
- Congenital malformation e.g. neural tube defects such as spina bifida
duration of antibiotics of complicated UTI
- 5-10 days of antibiotics for immunosuppressed women, abnormal anatomy or impaired kidney function
- 7 days of antibiotics for men, pregnant women or catheter-related UTIs
‘Multi-Drug Resistant Gran Negative Organism (MGNO)’
- Gram negative bacteria that are resistant to antibiotics that they have been sensitive to in the past
- MSU – to test for susceptibility
- Fosfomycin has been shown to retain some activity against MDR bacteria