Urology Flashcards
Furosemide
A. Loop diuretics
B. act on thick ascending limb of loop of henle where it inhibit reabsorption of Na/2Cl/K
C. Hypertension
Hydrocholorothiazide
A. Thiazide diuretics
B. acts on DCT - inhibit reabsorption of Na / Cl
C. Hypertension
Torasemide
A. Loop diuretics
B. act on thick ascending limb of loop of henle where it inhibit reabsorption of Na/2Cl/K
C. Hypertension
Eplerenone
A. Aldosterone antagonist (mineralcorticoid R blocker)
B. inhibit physiologic effect if aldosterone - increase excretion of Na and decrease excretion of K
C. Hypertension
Mannitol
A. Osmotic diuretics
B. act on PCT and thick descending limb of loop of henle where it inhibits reabsorption of Na and H2O
C. Hypertension, elevated intraocular pressure, prevent oliguric phase of acute renal failure
Tamsulosin
A. Alpha 1-R blocker
B. blocks alpha R on bladder and prostate - SM relaxation
C. Benign prostatic hyperplasia, help passage of kidney stones
Doxazosine
A. Alpha1- R blocker
B. binds to alpha R on prostate and bladder- SM relaxation
Binds to alpha1 R - vasodilation - decrease PVR - drop of BP
C. Hypertension, BPH, urinary outflow obstruction
Finasteride
A. 5 alpha reductase inhibitor (steroid)
B. blocks conversion of testosterone to dihydritesttoaterine (DHT)
C. BPH, male pattern baldness
Dutaseride
A. 5 alpha reductase inhibitor (steroid)
B. blocks conversion of testosterone to dihydritesttoaterine (DHT)
C. BPH
Oxybutynin
A. Muscarinic cholinoblocker (selective)
B. inhibit Ach binding to M-R - SM relaxation of the bladder
C. Over active bladder
Tolterodine
A. Muscarinic cholinoblocker (non- selective)
B. inhibit Ach binding to M-R - SM relaxation of the bladder
C. Over active bladder
Solifenacin
A. Muscarinic cholinoblocker (selective)
B. inhibit Ach binding to M-R - SM relaxation of the bladder
C. Over active bladder
Desmopressin
A. Anti diuretic H (synthetic replacement of vasopressin)
B. increases water reabsorption - decrease urine production
Increase plasma factor VIII, plasminogen activator - improves blood clotting
C. Diabetes, polyuria, haemophilia A, von Willebrand diseases
Sildenafil/ Viagra
A. Selective phosphodiesterase 5 inhibitor
B. selective inhibitor of PDE in penis and clitoris - vasodilation
Also used in patients with pulmonary HT- vasodilation
C. ED, pulmonary HT
Tadalafil/ Cialis
A. Selective phosphodiesterase 5 inhibitor (slower acting than Viagra)
B. selective inhibitor of PDE in penis and clitoris - vasodilation
C. ED