Urogynae Flashcards

1
Q

Indications for urodynamics

A

Failure of conservative management for urge urinary incontinence

Prior to any surgical procedure for urinary incontinence (unless clearly pure SUI with no symptoms of OAB or prolapse which is only 5% of urogynae population)

Any previous anterior compartment or incontinence surgery
Symptoms suggestive of voiding dysfunction
Symptoms suggestive of overflow incontinence
Neurological symptoms
Severe prolapse prior to surgery esp if pre- existing urinary incontinence

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2
Q

Definition of overactive bladder syndrome

A

Urgency + daytime frequency +/- nocturia +/- urinary incontinence

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3
Q

Urgency definition

A

A sudden compelling desire to void which is difficult to defer

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4
Q

Urge urinary incontinence

A

Incontinence accompanied by or immediately preceded by urgency

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5
Q

Urodynamic stress incontinence definition

A

Urodynamic diagnosis

Involuntary leakage provoked by increased intra- abdominal pressure and in the absence of increased detrusor contraction during filling cystometry

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6
Q

Detrusor overactivity definition

A

Urodynamic diagnosis

Involuntary detrusor contraction during filling cystometry which may be provoked or spontaneous

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7
Q

Things to do prior to urodynamics

A

Rule out UTI
Stop anticholinergics 10 days prior
Check compliance with conservative measures
Check bladder diary

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8
Q

Tell me about uroflowmetry

A

Measurement of flow rate over time

Woman voids in a commode that funnels urine into a device that measures flow rate over time

Looks at:
- max flow rate
- average flow rate
- total volume voided (must be >150ml to be interpretable)

This helps to diagnose or exclude voiding difficulties

You then look at post- void residuals with bladder scan or in + out catheter

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9
Q

Tell me about cystometry

A

Measure of the pressure- volume relationship of the bladder during filling and voiding.

Fluid (water/ saline) is infused into the bladder via a catheter.
Catheter in bladder measures intravesical pressure.
Catheter into rectum or vagina to measure IAP.

Detrusor pressure Pdet= Pves - Pabd

Assess:
- bladder sensation
- bladder capacity
- detrusor activity and compliance
- sphincter competence
- urine leakage

Do some provocative tests like coughing or wash hands

Aims to diagnose detrusor overactivity or urodynamic stress urinary incontinence

Voiding phase: pressure- flow study
- high pressure voiding= obstruction
- low pressure voiding = detrusor hypo- contractility

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10
Q

Pressure- flow studies

A

Pt voids while pressure transducer is still in
Relationship between pressure in the bladder and urine flow during emptying = detrusor contractility

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11
Q

Urethral pressure profile

A

Measures urethral closure pressure= bladder pressure- urethral pressure

Normally, urethra closure pressure is maintained during filling even with increased IAP.
Leakage occurs when bladder pressure exceeds urethral pressure

Clinical value is unknown

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12
Q

Leak point pressures

A

The bladder pressure at which leakage occurs.

Abdominal leak point pressure- the intravesicular pressure at which leakage occurs due to increased abdominal pressure in the absence of detrusor contraction. Provoked by coughing/ position change

Detrusor leak point pressure- the intravesicular pressure at which leakage occurs due to a detrusor contraction in the absence of increased abdo pressure. Provoked by running water/ visual cues.

A low abdo leak point pressure (<60) can be associated with intrinsic sphincter deficiency

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13
Q

Videocystourethrography

A

Combines cystometry with contrast as filling fluid, with radiological assessment of the bladder and urethra

Anatomical and functional features can be reviewed simultaneously.

Use in patients with neuro conditions or suspected bladder neck opening reflux or fistula

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14
Q

Normal post void residual

A

< 100ml

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15
Q

Intrinsic sphincter deficiency

A

Urodynamic diagnosis

ALPP < 60 cmH2O
MUCP < 20 cm H2O

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16
Q

Anticholinergics for OAB

A

M2 and M3 main urinary receptors. M3 responsible for detrusor contraction.

MOA:
- reduce uninhibited detrusor contractions
- reduce intravesicular pressure
- therefore increased volume threshold

CI:
- myasthenia gravis
- closed angle glaucoma
- tachy arrhythmia

Some evidence that increases risk of dementia with exposure from 1- 11 years

17
Q

Beta- 3 adrenoreceptor agonist (Betmiga)

A

Promotes detrusor relaxation and increases stability during bladder storage.

Decreases number of voids and incontinence episodes compared to placebo

CI:
- severe uncontrolled HTN
- severely reduced liver function
- pregnancy
- breastfeeding
- < 18 yo

Caution with:
- prolonged QT interval

18
Q

What is the vaginal mesh exposure rate?

A

2%

19
Q

Level 1 pelvic organ support

A

Uterosacral and cardinal ligaments
Vertical suspension of the uterus, cervix and vagina
Supports the upper 1/3 of the vagina and cervix
Level 1 defects lead to apical descent

20
Q

Level 2 pelvic organ support

A

Paravaginal fascia (part of the endopelvic fascia) which connects the vagina to the white line or arcus tendinuos fascia pelvis (ATFP) which is the origin of the levator ani muscles

Supports the upper 2/3 of the vagina and rectum
Level 2 defects lead to cystocele

21
Q

Level 3 pelvic organ support

A

Fusion of the vaginal endopelvic fascia to the:
- perineal body posteriorly
- levator ani muscles laterally
- urethra anteriorly

Supports the lower 1/3 of vagina, urethra and anal canal

Level 3 defects lead to rectocele, urethral hypermobility and SUI

22
Q

Prolapse stage

A

Stage 0: Aa, Ba, Ap, Bp = -3cm and C or D </= (tvl- 2) cm

Stage 1: leading edge of prolapse at or < -1cm

Stage II: leading edge at or > +1cm

Stage III: leading edge is > 1cm but without complete eversion

Stage IV: complete vaginal eversion

23
Q

Ideal patient for conservative management of prolapse

A

Mild to moderate prolapse/ symptoms
Not completed family
Frail patients
Women wishing to avoid/ delay surgery
Women not fit for surgery

24
Q

POPPY Trial for prolapse

A

One- to- one PFMT vs pamphlet giving lifestyle advice only.
Mostly stage I- II prolapse

Outcome: PFMT reduced symptoms of POP but does not alter severity/ stage of prolapse

25
Q

PREVPROL RCT 2015 for POP

A

One- to- one PFMT (over 16 weeks) + Pilates based PFMT classes + a DVD for home use vs a prolapse lifestyle advice leaflet

Results:
- significantly improved POP sx at 1 and 2 years.
- Prolapse related QOL did not differ significantly between groups over 2 years but the intervention group sought less further treatment over 2 years