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CRRAB II--Wk 5 > URIs > Flashcards

URIs Flashcards

1
Q

Rhinovirus

Virulence Factors

Pathology

Presentation

A

VF: binds ICAM-1 on upper resp tract epithelial cells

Path: intracellular replication, increased ICAM-1 expression in adjacent cells

Presentation: common cold

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2
Q

Parainfluenza Virus

Virulence Factors

Pathology

Presentation

A

VF: viral fusion (F) surface proteins

⇒ formation of multinucleate giant cells

Path: viral hemaglutinin (HA) binds envelope protein with sialic acid on cell surfaces

⇒ endocytosis

viral neurominidase envelope cleaves HA bound to sialic acid

⇒ permits viral spread

can move down respiratory tract

Presentation: croup, pneumonia

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3
Q

Coronavirus

Virulence Factors

Pathology

Presentation

A

VF: none identified

Path: same as rhino

Presentation: common cold, SARS (severe acute respiratory syndrome)

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4
Q

Influenza C

Virulence Factors

Pathology

Presentation

A

VF: ?

Path: viral hemagglutinin (HA) envelope binds sialic acid on cell surfaces

⇒ endocytosis

viral neurominidase protein claves HA bound to sialic acid

⇒ viral spread

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5
Q

Most common bugs in sinusitis

A

S. pneumoniae

Hib

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6
Q

S. pneumoniae

classification

A

Gram +

diplococci

catalase -

α-hemolytic

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7
Q

H. influenzae b

classification

A

Gram -

coccobacilli

grows on chocolate agar

(Factor V and X)

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8
Q

Causes SARS

A

coronavirus

Class IV

enveloped

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9
Q

Bacterial pharyngitis causes

A

S. pyogenes

C. diphtheriae

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10
Q

S. pyogenes

classification

A

Gram +

cocci

Catalase -

β-hemolytic

bacitracin sensitive

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11
Q

C. diptheriae

classification

A

Gram +

ROD

non-motile

non-spore forming

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12
Q

C. diphtheriae

viruluence factors

A

exotoxins A and B

B: bind

A: attack

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13
Q

S. pyogenes

virulence factors

A

M-protein: avoids phagocytosis

lipotechoic acid

F-protein: attach and adhere

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14
Q

Croup

common causes

A

parainfluenza

RSV

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15
Q

Parainfluenza

classification

A

Class V

paramyxoviridae

enveloped

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16
Q

RSV classification

A

Class V

paramyxoviridae

17
Q

Croup causes viruses

classes

A

Class V

RSV

Parainfluenza

Influenza

18
Q

Group V virus

enveloped or not?

A

enveloped

19
Q

All other URI virus

+

exception

A

Class IV

except

adenovirus (Class I)

20
Q

Class I virus

A

adenovirus

21
Q

Adeno

enveloped or not?

A

non-enveloped

22
Q

Class IV enveloped or not?

A

all enveloped

except rhinovirus

23
Q

Tx of bacterial pharyngitis

A

penicillin or erythromycin

+ antitoxin for diptheria

24
Q

Sinusitis

Quellung +

A

S. pneumoniae

CRRAB II--Wk 5 (9 decks)

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